Guatemalan plants extracts as virucides against HIV-1 infection

Bedoya, Luis Miguel; Álvarez, Amparo; Bermejo, Mercedes; Gonzàlez, Núria; Beltrán, Manuela; Sánchez-Palomino, Sonsoles; Cruz, Sully M.; Gaitán, Isabel; Olmo, Esther del; Escarcena, Ricardo; García, Pablo A.; Cáceres, Armando; Feliciano, Arturo San; Alcamı́, José

doi:10.1016/j.phymed.2007.10.006

Cited by 18 publications

(12 citation statements)

References 16 publications

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“…Leaf extracts from J. reptans display a clear virucidal effect on HIV, which was attributed to two glycosylated flavonoids that have not yet been identified (Bedoya, 2008). Compounds of this chemical class have been previously reported to display anti-HIV properties including reverse transcriptase or integrase inhibition, but this is the first time that they are described as virucides (Kumar et al, 2005).…”

Section: Compounds Isolated From Species Of Justiciamentioning

confidence: 99%

“…Lignans also show antiangiogenic, antileishmanial, antifungal, hypolipidemic, antiasthmatic (Vasilev & Ionkova, 2005), antiviral (Asano et al, 1996), antineoplastic (Gordaliza et al, 2000), antifeedant (Bedoya et al, 2008), insecticidal, cardiotonic, antidepressant (Ghosal et al, 1979), analgesic, antiplatelet (Chen et al, 1996), and anti-inflammatory (Navarro et al, 2004) indications, as well as activity as lipid peroxidation inhibitors. Potent anti-inflammatory activities were described for lignan glycosides isolated from J. ciliata (Day et al, 2000) and phenolic compounds isolated from J. prostrata (Sanmugapriya et al, 2005b).…”

Section: Compounds Isolated From Species Of Justiciamentioning

confidence: 99%

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Chemical constituents and biological activities of species of Justicia: a review

Corrêa¹,

Alcântara²

2012

Rev. bras. farmacogn.

123

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Abstract:The Acanthaceae family is an important source of therapeutic drugs, and the ethnopharmacological knowledge of this family requires urgent documentation as several of its species are near extinction. Justicia is the largest genus of Acanthaceae, with approximately 600 species. The present work provides a review addressing the chemistry and pharmacology of the genus Justicia. In addition, the biological activities of compounds isolated from the genus are also covered. The chemical and pharmacological information in the present work may inspire new biomedical applications for the species of Justicia, considering atom economy, the synthesis of environmentally benign products without producing toxic by-products, the use of renewable sources of raw materials, and the search for processes with maximal efficiency of energy.

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Section: Compounds Isolated From Species Of Justiciamentioning

confidence: 99%

Section: Compounds Isolated From Species Of Justiciamentioning

confidence: 99%

Chemical constituents and biological activities of species of Justicia: a review

Corrêa¹,

Alcântara²

2012

Rev. bras. farmacogn.

123

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“…-Anti-HIV activity by the methanol extract of P. viridis leaves when tested using MTT and recombinant viruses (RV) assays (Bedoya et al, 2008).…”

Section: Othersmentioning

confidence: 99%

Genus Pouteria: chemistry and biological activity

Silva¹,

Simeoni²,

Silveira³

2009

Rev. bras. farmacogn.

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RESUMO: "Gênero Pouteria: Química e atividade biológica". O gênero Pouteria pertence à família Sapotaceae e pode ser encontrado em muitos continentes. As plantas desse gênero têm sido utilizadas na construção civil, na alimentação e também na medicina popular. Algumas atividades biológicas são reportadas às espécies desse gênero, tais como, antioxidante, anti-inflamatória, antibacteriana e antifúngica, mas seu real potencial como fonte de novos fármacos ainda é pouco conhecido. Assim, uma revisão sobre a composição química e as atividades biológicas de Pouteria é apresentada, com o intuito de estimular a continuação dos estudos das espécies aqui citadas, e a investigação de outras espécies para as quais não foram encontrados relatos.Unitermos: Pouteria, Sapotaceae, triterpenos, flavonoides, plantas medicinais. ABSTRACT:The genus Pouteria belongs to the family Sapotaceae and can be widely found around the World. These plants have been used as building material, as food, because the eatable fruits, as well as remedies in folk medicine. Some biological activities have been reported to species of this genus such as antioxidant, anti-inflammatory, antibacterial and antifungal. However, the real potential of this genus as source of new drugs or phytomedicines remains unknown. Therefore, a review of the so far known chemical composition and biological activities of this genus is presented to stimulate new studies about the species already reported moreover that species have no reference about chemistry or biological activities could be found until now.

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“…The whole fruit aqueous or hydroalcoholic extracts of Punica granatum L. (Punicaceae) had proved highly active against the influenza virus (Angel et al, 2008). Three Guatemalan plant extracts from Justicia reptans, Neurolaena lobata and Pouteria viridis were found to inhibit HIV replication and their hydroalcoholic extracts resulted in reversion and gene-conversion test in microorganisms, sister chromatid exchanges, micronuclei and sperm-shape abnormality assays in mice (Bedoya et al, 2008). In short, plants play an important role in antibacterial activities and controlling virus.…”

Section: Introductionmentioning

confidence: 98%

Hydrophytes may play an important role in sewage disinfection in constructed wetlands

Zhang

Wang

2009

J. of Wat. & Envir. Tech.

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Double agar overlay (DAL) method was used to evaluate the inhibition of hydrophytes extracts on coliphages growth by the plaque forming unit (PFU) assay. The present research investigated allelopathic effects of extracts from five hydrophytes leaf, Polygonum hydropiper, Polygonum orientale, Phragmites communis, Arundo donax and Typha latifolia on two coliphages, T4 and f2. The results showed that different hydrophytes inhibit coliphage (T4 and f2) to various extents, and the inhibition of extracts from P. hydropiper was more effective on coliphage T4 and f2 than other hydrophytes. When the concentration of extracts was 0.5g·L -1 , the inhibition rate of P. hydropiper leaf on coliphage T4, f2 was 91%, 93%, respectively. The EC 50 of P. hydropiper leaf on coliphage T4 was 10mg·L -1 ，and the EC 50 on coliphage f2 was 12.6mg·L -1 . The EC 50 on coliphage T4, f2 of T. latifolia leaf was 16 mg·L -1 , 20 mg·L -1 , respectively. The P. hydropiper showed the greatest inhibition on coliphage. The allelochemicals produced by P. hydropiper should be isolated and evaluated in the following research. More research should be done to evaluate potential use of P. hydropiper in wastewater virus controlling.

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Guatemalan plants extracts as virucides against HIV-1 infection

Cited by 18 publications

References 16 publications

Chemical constituents and biological activities of species of Justicia: a review

Chemical constituents and biological activities of species of Justicia: a review

Genus Pouteria: chemistry and biological activity

Hydrophytes may play an important role in sewage disinfection in constructed wetlands

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