Gross and histomorphological effects of formaldehyde on brain and lungs of Swiss albino mice

Abstract

Formaldehyde (FA) is toxic over a range of doses and of particular concern to anatomists and medical students on laboratory use. FA induces several characteristics of neurotoxicity in addition to systemic effects. Therefore, to know the toxic effects of FA on brain and lungs, mice were collected from international center for diarrheal disease research. They were divided into four groups i.e. control, inhalation, oral and intraperitoneal. The inhalation, oral and intraperitoneal exposure groups further divided into three subgroups which were subjected to exposure of FA daily for 30 days in case of inhalation and oral groups and 10 days in intraperitoneal group for acute toxic effects. Morphological study showed gross abnormalities i.e. congestion on lungs. But no gross abnormal features observed on brain. In 5 ppm treated inhaled group, lungs tissue revealed hemorrhages. In the inhaled groups, brain tissue showed degenerating neurons with either pyknotic or karyorrhectic nuclei are gradually increased in highest concentration group. These data supports the view that FA has adverse effects on the morphology of brain and lungs.

Effect of Formaldehyde on The Structure of The Lung and Heart and The Possible Protective Effect of Omega- 3 (Histological and immune-histochemical study)

“…In the present study, the gross morphological study of the lungs exposed to formaldehyde revealed irregular convoluted surfaces of most lungs, increased congestion, and appearance of masses. These results are in agreement with previous studies whereas rats were exposed to formaldehyde for different durations which showed congestion in most lobes and focal pneumonic organization (Khaliq and Tripathi, 2009;Afrin et al, 2016;El Desouky et al, 2019).…”

Measurement of Air Concentrations of Particulate Matters, Volatile Organic Compounds and Formaldehyde in Lahore

“…11 It also passes through the blood-brain barrier thus affecting brain and nerve cells and alter emotional or cognitive behavior causing headache, dizziness, sleep disorders and memory loss. 12,13 In our study the workers experienced symptoms of asthma, headache and dizziness occasionally Hence, the fear of health repercussions on people who are stranded at these spots for hours such as the policemen on duty, vendours and the school children who have to walk along these heavily polluted roads.…”