Formaldehyde toxicity reports from <i>in vitro</i> and <i>in vivo</i> studies: a review and updated data

Bernardini, Letícia; Barbosa, Eduardo José; Charão, Mariele Feiffer; Brucker, Natália

doi:10.1080/01480545.2020.1795190

Cited by 57 publications

(43 citation statements)

References 74 publications

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“…The link of inflammation to neuronal damage is evident from numerous reports. Some of the major toxic compounds in cigarette smoke are especially well known to cause systemic and cardiovascular inflammation (Figure 3), which also holds true for the brain, as reported for particulate matter [152,168], heavy/transition metal ions [169,170], reactive aldehydes [171,172], and volatile organic compounds [173,174]. The following experimental animal studies support inflammation-mediated neuronal damage that may contribute to aforementioned neuropsychiatric disease in smokers.…”

Section: Smoking and Brain Changes Affecting Neuropsychiatric Pathophysiologysupporting

confidence: 69%

Smoking and Neuropsychiatric Disease—Associations and Underlying Mechanisms

Hahad

Daiber

Michal

et al. 2021

IJMS

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Despite extensive efforts to combat cigarette smoking/tobacco use, it still remains a leading cause of global morbidity and mortality, killing more than eight million people each year. While tobacco smoking is a major risk factor for non-communicable diseases related to the four main groups—cardiovascular disease, cancer, chronic lung disease, and diabetes—its impact on neuropsychiatric risk is rather elusive. The aim of this review article is to emphasize the importance of smoking as a potential risk factor for neuropsychiatric disease and to identify central pathophysiological mechanisms that may contribute to this relationship. There is strong evidence from epidemiological and experimental studies indicating that smoking may increase the risk of various neuropsychiatric diseases, such as dementia/cognitive decline, schizophrenia/psychosis, depression, anxiety disorder, and suicidal behavior induced by structural and functional alterations of the central nervous system, mainly centered on inflammatory and oxidative stress pathways. From a public health perspective, preventive measures and policies designed to counteract the global epidemic of smoking should necessarily include warnings and actions that address the risk of neuropsychiatric disease.

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Section: Smoking and Brain Changes Affecting Neuropsychiatric Pathophysiologysupporting

confidence: 69%

Smoking and Neuropsychiatric Disease—Associations and Underlying Mechanisms

Hahad

Daiber

Michal

et al. 2021

IJMS

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“…Of course this needs to be a concern, especially for the Indonesian government in preventing the abuse of formaldehyde. Because after all, formaldehyde is toxic which can have a negative effect on body health, and can even cause cancer and even death (Tang, et al, 2009;Freeman et al 2009;Hauptmann et al 2009;Scheuplein, 1985;Restani and Galli, 1991;Zhao, et al, 2021;Bernardini et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have shown the reactive and carcinogenic properties of formaldehyde, such as leukemia and nasopharyngeal cancer (Tang, et al, 2009;Freeman et al 2009;Hauptmann et al 2009;Scheuplein, 1985;Restani and Galli, 1991). ;Zhao, et al, 2021;Bernardini et al, 2020). According to Hasmalina, Alfayed and Helvina (2018), apart from being influenced by the level of formaldehyde that enters the body, the negative effects of formaldehyde on health also depend on contact or the way formaldehyde is exposed to the body.…”

Section: Toxic Effect Of Formaldehydementioning

confidence: 99%

Analysis of formaldehyde content in salted fish at Ciroyom market, Bandung City, Indonesia

Utama

Nurwidiyanto

Baehaki

et al. 2021

J. of Sustainability Sci. and Tech.

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Salted fish is one of the processed fish products that are in great demand by the people of Indonesia. This type of preparation has good durability with natural processes. However, there are some cases that use chemicals as preservatives, such as formaldehyde. This study aims to determine the formaldehyde content in salted fish that is traded in the market in Indonesia. This research is descriptive and the sample is taken from Ciroyom Market, Bandung City, Indonesia, randomly. Samples were analyzed qualitatively to observe the physical characteristics of salted fish. In addition, quantitative analysis was also carried out to determine the level of formaldehyde present in salted fish using a UV-Vis spectrophotometer at a wavelength of 520 nm. The results of the analysis showed that 4 of the 15 samples tested contained formaldehyde with a concentration of 0.033 – 0.482 ppm. The characteristics of these samples physically also have similarities with the characteristics of fish containing formaldehyde, namely bright white and hard textured.

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“…In this this study most of the sites measured are above this level.Various studies show that formaldehyde causes upper respiratory tract irritation and on chronic exposure causes metaplastic changes in the respiratory tract and lungs. 11 It also passes through the blood-brain barrier thus affecting brain and nerve cells and alter emotional or cognitive behavior causing headache, dizziness, sleep disorders and memory loss. 12,13 In our study the workers experienced symptoms of asthma, headache and dizziness occasionally Hence, the fear of health repercussions on people who are stranded at these spots for hours such as the policemen on duty, vendours and the school children who have to walk along these heavily polluted roads.…”

Section: Discussionmentioning

confidence: 99%

Measurement of Air Concentrations of Particulate Matters, Volatile Organic Compounds and Formaldehyde in Lahore

Aslam¹,

Javed²,

Reyaz³

2020

BIOMEDICA

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Background and Objective:The volatile organic compounds (VOCs) including formaldehyde (HCHO) are widely concerned due to their harmful impact on human health by productionof photochemical smog and ozone and have great impacton air quality. High air pollution level in urban areas is one of the major concerns therefore, there is need to develop cost-effective devices for measurement of VOCs in the environment. The objective of the study was to quantify the levels of these hazardous chemicals in air in major areas of Lahore.Methods: This study was a cross-sectional descriptive study. A new multi-item pollution monitoring device (Life Basis DM 106 A) was used to carry out the readings. The areas targeted were busy areas of Lahore including Jail Road,

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Formaldehyde toxicity reports from in vitro and in vivo studies: a review and updated data

Cited by 57 publications

References 74 publications

Smoking and Neuropsychiatric Disease—Associations and Underlying Mechanisms

Smoking and Neuropsychiatric Disease—Associations and Underlying Mechanisms

Analysis of formaldehyde content in salted fish at Ciroyom market, Bandung City, Indonesia

Measurement of Air Concentrations of Particulate Matters, Volatile Organic Compounds and Formaldehyde in Lahore

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