Grafting of doxycycline imprinted polymers on silica surface for selective solid-phase extraction in beef samples

Chen, Taojing; Zhao, Jingchan; Guo, Zhian; Zhang, Baixin

doi:10.1039/c2ay26084k

Cited by 3 publications

(3 citation statements)

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“…The MIPs with high selectivity and physicochemical stability have been applied in the field of separation, assays, sensor design and catalysis. [1][2][3][4][5] A particularly promising application of MIPs is as selective phases in solid-phase extraction (MISPE) for selective enrichment and clean-up of analytes at low concentrations or in complex matrices. 3 The extraction efficiency is mainly dependent on the properties of the imprinted materials, the structure of the polymeric matrix and the function of the binding groups.…”

Section: Introductionmentioning

confidence: 99%

“…6 The organic polymeric imprinted matrix was first reported by Wulff 7 in 1972 and extensively applied due to its excellent pH stability, high adsorption capacity and easy availability of various monomers, but it shows swelling in different solvents. [1][2][3][4][5][6][7][8] The swelling properties of MIPs will lead to a particularly slow mass transfer and reduction of their lifetime, and accessible binding sites decrease due to a slight contraction of the polymer when used in MISPE. 3 For decreasing swelling of the organic polymeric imprinted matrix, the molecularly imprinted organic-inorganic hybrid mesoporous sorbents (hybrid-based MIPs) were developed.…”

Section: Introductionmentioning

confidence: 99%

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Adsorption-controlled preparation of molecularly imprinted hybrid composites for selective extraction of tetracycline residues from honey and milk

Zhang

et al. 2014

New J. Chem.

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Molecularly imprinted organic-inorganic hybrid composite materials (MIP-HCMs) with controlled swelling and adsorption properties were prepared through copolymerization and the sol-gel process by using doxycycline (DC) as the template molecule, methacrylic acid (MAA) as a functional monomer, methacryloxypropyltrimethoxysilane (KH-570) as a coupling agent and TEOS as an inorganic precursor. By means of changing polymerization conditions as well as the copolymerization ratio of the inorganic precursor and the organic functional monomer, the properties of sorbents can be adjusted for different needs.So the effect of preparation conditions on the structure of the material was studied. The polymer group, thermal stability, adsorption and selectivity characteristics, and the volume swelling degree of the MIP-HCMs were characterized by FTIR, TGA, and dynamic adsorption and swelling experiments, respectively.It was observed that the MIP-HCMs exhibited the highest selectivity (4.9), maximum adsorption capacity (58.2 mg g À1 ) and good thermal stability. The obtained MIP-HCM was used as an adsorbent for solid-phase extraction of tetracyclines from the milk and honey samples. The average recoveries of three tetracycline antibiotics (DC, tetracycline and chlortetracycline) were obtained in the range of 74.7-115.5% with the precision of 2.1-4.9%. The limits of detection and quantitation of the proposed method were in the range of 4.9-15.3 mg kg À1 and 16.6-51.0 mg kg À1 for the milk samples, and 8.3-15.1 mg kg À1 and 18.3-50.2 mg kg À1 for the honey samples, respectively.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Adsorption-controlled preparation of molecularly imprinted hybrid composites for selective extraction of tetracycline residues from honey and milk

Zhang

et al. 2014

New J. Chem.

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“…The solution was sonicated for 15 mins and then heated to 60 o C with overhead stirring under nitrogen overnight. The resultant FeO x @SiO2-MPA microspheres were washed several times using ethanol and dried for 10 hrs under vacuum.The synthesis of the MIP layer is based on a previous report with some modifications[27].A solution containing MAA (4 mmol), EDGMA (8 mmol), doxycycline (1 mmol), and fluorescein-o-acrylate (0.1 mM) in methanol (60 ml) was prepared and degassed by bubbling nitrogen for 30 mins. The solution was added to a three-way round bottom flask containing 0.2 g of FeO x @SiO2-MPA, sonicated for 15 mins and stirred for one hr at room temperature.…”

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confidence: 99%

A multifunctional molecularly imprinted polymer-based biosensor for direct detection of doxycycline in food samples

Ashley

Feng

Sun

2018

Talanta

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In this study, we developed a new type of multifunctional molecularly imprinted polymer (MIP) composite as an all-in-one biosensor for the low-cost, rapid and sensitive detection of doxycycline in pig plasma. The MIP composite consisted of a magnetic core for ease of manipulation, and a shell of fluorescent MIPs for selective recognition of doxycycline. By simply incorporating a small amount of fluorescent monomer (fluorescein-O-acrylate), the fluorescent MIP layer was successfully grafted onto the magnetic core via a surface imprinting technique. The resultant MIP composites showed significant doxycycline-dependent fluorescence quenching in an aqueous environment. Good linearity ranging from 0.2 to 6 µM was achieved, and the limit of detection was determined to be 117 nM. The biosensor also showed good selectivity towards doxycycline when compared to other common antibiotic residues. The multifunctional MIP composites were used to directly extract doxycycline from spiked pig plasma samples and quantify the antibiotics based on the quenched fluorescence signals. Recoveries of doxycycline were found in the range of 88-107%.

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The Application of Molecularly Imprinted Polymers to Solid-Phase Extraction

Pei

Shen

2014

AMR

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A benefit of imprinted polymers is the possibility to prepare sorbents with selectivity pre-determined for a particular substance, or group of structural analogues. The application most close to a wider acceptance is probably that of solid phase extraction for clean-up of environmental and biological samples. The technique of molecularly imprinted polymers to solid phase extraction (MISPE) is performance and high selectively, compared with traditional sorbents. In this paper, the preparation and application of MIPs would be reviewed.

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Grafting of doxycycline imprinted polymers on silica surface for selective solid-phase extraction in beef samples

Cited by 3 publications

References 21 publications

Adsorption-controlled preparation of molecularly imprinted hybrid composites for selective extraction of tetracycline residues from honey and milk

Adsorption-controlled preparation of molecularly imprinted hybrid composites for selective extraction of tetracycline residues from honey and milk

A multifunctional molecularly imprinted polymer-based biosensor for direct detection of doxycycline in food samples

The Application of Molecularly Imprinted Polymers to Solid-Phase Extraction

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