The Application of Molecularly Imprinted Polymers to Solid-Phase Extraction

Abstract

A benefit of imprinted polymers is the possibility to prepare sorbents with selectivity pre-determined for a particular substance, or group of structural analogues. The application most close to a wider acceptance is probably that of solid phase extraction for clean-up of environmental and biological samples. The technique of molecularly imprinted polymers to solid phase extraction (MISPE) is performance and high selectively, compared with traditional sorbents. In this paper, the preparation and application of MIPs would be reviewed.

Molecular Dynamic Study of Mechanism Underlying Nature of Molecular Recognition and the Role of Crosslinker in the Synthesis of Salmeterol-Targeting Molecularly Imprinted Polymer for Analysis of Salmeterol Xinafoate in Biological Fluid

“…As a smart synthetic material, MIP is extensively used in numerous areas including sensors, chromatography, drug delivery systems, and environmental separations/analysis [ 9 ]. The application of MIPs is particularly used in solid phase extraction [ 10 , 11 , 12 ] and, moreover, it is used in analytical columns in chromatography [ 13 , 14 , 15 ] and as a film layer in sensors [ 16 , 17 , 18 ]. It is known that the selective recognition of MIP-ligand comes from the interaction between the template and the functional monomer present in the pre-polymerization solution [ 19 ].…”