Glycan based Detection and Drug Susceptibility of Influenza Virus

Dinh, Hieu; Zhang, Xiaohu; Sweeney, Joyce; Yang, Yang; He, Yan; Dhawane, Abasaheb N.; Iyer, Suri S.

doi:10.1021/ac501624v

Cited by 20 publications

(13 citation statements)

References 26 publications

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“…Hieu and co-workers have developed a range of synthetic glycans as receptor mimics of the virus and then printed these glycan channels onto a commercial glass slide via a free amine at the end of a spacer to produce a small focused microarray, and utilized it for the detection of viruses. This microarray has detected different strains of the influenza A virus ( Hieu et al., 2014 ).…”

Section: Carbohydrates-based Diagnosis Of Covid-19mentioning

confidence: 99%

“…The carbohydrate based biomolecules are reported to be less toxic, biocompatible and immunogenic in traditional Chinese herbal medicine. The synthetic glycan molecules mimicking receptor of the viruses are found promising in the diagnosis of viruses ( Hieu et al., 2014 ). Both plant and micro-organisms derived polysaccharides such as chitosan (CS), glucans, dextran, inulin, etc.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Carbohydrates-based diagnosis, prophylaxis and treatment of infectious diseases: Special emphasis on COVID-19

Kumbhar¹,

Pandya²,

Manjappa³

et al. 2021

Carbohydrate Polymer Technologies and Applications

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COVID-19 pandemic is taking a dangerous turn due to unavailability of approved and effective vaccines and therapy. Currently available diagnostic techniques are time-consuming, expensive, and maybe impacted by the mutations produced in the virus. Therefore, investigation of novel, rapid, and economic diagnosis techniques, prophylactic vaccines and targeted efficacious drug delivery systems as treatment strategy is imperative. Carbohydrates are essential biomolecules which also act as markers in the realization of immune systems. Moreover, they exhibit antiviral, antimicrobial, and antifungal properties. Carbohydrate-based vaccines and therapeutics including stimuli sensitive systems can be developed successfully and used effectively to fight COVID-19. Thus, carbohydrate-based diagnostic, prophylactic and therapeutic alternatives could be promising to defeat COVID-19 propitiously. Morphology of SARS-CoV-2 and its relevance in devising combat strategies has been discussed. Carbohydrate-based approaches for tackling infectious diseases and their importance in the design of various diagnostic and treatment modalities have been reviewed.

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Section: Carbohydrates-based Diagnosis Of Covid-19mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Carbohydrates-based diagnosis, prophylaxis and treatment of infectious diseases: Special emphasis on COVID-19

Kumbhar¹,

Pandya²,

Manjappa³

et al. 2021

Carbohydrate Polymer Technologies and Applications

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“…Sialic acid bound to gold nanoparticles can bind with the HA of the virus, thus producing the signals for virus detection (Lee et al 2013 ). The glycans have been printed in the glass slides to form a microarray (Dinh et al 2014 ) which can detect various strains of influenza virus up to ten plaque-forming units. Portable lateral flow tests have also been developed for the diagnosis of influenza virus (Sajid et al 2015 ).…”

Section: Applications Of Biosensors In Animal Husbandrymentioning

confidence: 99%

Biosensors: Modern Tools for Disease Diagnosis and Animal Health Monitoring

Tewari

Jain²,

Brar

et al. 2021

Concepts and Strategies in Plant Sciences

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Animals play a vital role in our lives as they provide milk, meat, and other by-products for daily consumption. At the same time, their health directly/indirectly affects human beings as we both share a common environment. The One Health concept makes it imperative that the animals should remain healthy as it will have an impact on our health as well as economy. Animal disease diagnosis, their health monitoring, prevention, and control of diseases are important from this aspect. Tools for rapid diagnosis of animal diseases are crucial for early diagnosis and imposing control measures. Molecular techniques such as, genome sequencing, restriction fragment length polymorphism (RFLP), DNA microarray, PCR, and real-time PCR are some of the rapid techniques, but they need expertise and sophisticated labs. Conventional methods such as isolation of the pathogen, serological techniques, are laborious and time taking process. Therefore, to overcome the said limitations of conventional and molecular tools, biosensors are the better alternatives as they are rapid and can be used as pen-side diagnostic tests. They can provide test results in a few minutes under field conditions. In this chapter, we give an elaborative description of various types of biosensors and their utility in animal disease diagnostics and health monitoring.

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“…This reaction may produce a signal in colorimetric test that is linearly proportional to the virus titer (Figure 2 ). A recent study reported that glycan can be printed onto glass slides to generate microarray [ 43 ]. The microarray was shown to capture different strains of influenza virus with a clinical relevant limit of detection (ten plaque forming units) allowing virus diagnostics.…”

Section: Detection Of Avian Influenza Virusesmentioning

confidence: 99%

Advanced biosensors for detection of pathogens related to livestock and poultry

Vidić

Manzano

Chang

et al. 2017

Vet Res

200

124

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Infectious animal diseases caused by pathogenic microorganisms such as bacteria and viruses threaten the health and well-being of wildlife, livestock, and human populations, limit productivity and increase significantly economic losses to each sector. The pathogen detection is an important step for the diagnostics, successful treatment of animal infection diseases and control management in farms and field conditions. Current techniques employed to diagnose pathogens in livestock and poultry include classical plate-based methods and conventional biochemical methods as enzyme-linked immunosorbent assays (ELISA). These methods are time-consuming and frequently incapable to distinguish between low and highly pathogenic strains. Molecular techniques such as polymerase chain reaction (PCR) and real time PCR (RT-PCR) have also been proposed to be used to diagnose and identify relevant infectious disease in animals. However these DNA-based methodologies need isolated genetic materials and sophisticated instruments, being not suitable for in field analysis. Consequently, there is strong interest for developing new swift point-of-care biosensing systems for early detection of animal diseases with high sensitivity and specificity. In this review, we provide an overview of the innovative biosensing systems that can be applied for livestock pathogen detection. Different sensing strategies based on DNA receptors, glycan, aptamers and antibodies are presented. Besides devices still at development level some are validated according to standards of the World Organization for Animal Health and are commercially available. Especially, paper-based platforms proposed as an affordable, rapid and easy to perform sensing systems for implementation in field condition are included in this review.

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Glycan based Detection and Drug Susceptibility of Influenza Virus

Cited by 20 publications

References 26 publications

Carbohydrates-based diagnosis, prophylaxis and treatment of infectious diseases: Special emphasis on COVID-19

Carbohydrates-based diagnosis, prophylaxis and treatment of infectious diseases: Special emphasis on COVID-19

Biosensors: Modern Tools for Disease Diagnosis and Animal Health Monitoring

Advanced biosensors for detection of pathogens related to livestock and poultry

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