Biosensors: Modern Tools for Disease Diagnosis and Animal Health Monitoring

Tewari, A. N.; Jain, Beenu; Brar, Basanti; Prasad, Gaya; Prasad, Minakshi

doi:10.1007/978-3-030-66165-6_18

Cited by 3 publications

(1 citation statement)

References 158 publications

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“…For efficient onsite screening, there is a lack of portable devices that can be used directly on site for early detection (Vidic et al 2017 ). The need of robust and fast detection has been addressed by a number of new approaches in biosensors (Tewari et al 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Detection of viral antibodies in camel sera using magnetic particle spectroscopy

Friedrich

Vogel

Rückert

et al. 2023

Appl Microbiol Biotechnol

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Pandemics like SARS-Cov-2 very frequently have their origin in different animals and in particular herds of camels could be a source of zoonotic diseases. This study took advantage on a highly sensitive and adaptable method for the fast and reliable detection of viral antibodies in camels using low-cost equipment. Magnetic nanoparticles (MNP) have high variability in their functionalization with different peptides and proteins. We confirm that 3-aminopropyl triethoxysilane (APTES)-coated MNP could be functionalized with viral proteins. The protein loading could be confirmed by simple loading controls using FACS-analysis (p < 0.05). Complementary combination of antigen and antibody yields in a significant signal increase could be proven by both FACS and COMPASS. However, COMPASS needs only a few seconds for the measurement. In COMPASS, the phase φn on selected critical point of the fifth higher harmonic (n = 5th). Here, positive sera display highly significant signal increase over the control or negative sera. Furthermore, a clear distinction could be made in antibody detection as an immune response to closely related viruses (SARS-CoV2 and MERS). Using modified MNPs along with COMPASS offers a fast and reliable method that is less cost intensive than current technologies and offers the possibility to be quickly adapted in case of new occurring viral infections. Key points • COMPASS (critical offset magnetic particle spectroscopy) allows the fast detection of antibodies. • Magnetic nanoparticles can be adapted by exchange of the linked bait molecule. • Antibodies could be detected in camel sera without washing steps within seconds.

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Section: Introductionmentioning

confidence: 99%

Detection of viral antibodies in camel sera using magnetic particle spectroscopy

Friedrich

Vogel

Rückert

et al. 2023

Appl Microbiol Biotechnol

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Characterization, optimization, and evaluation of preservative efficacy of carboxymethyl cellulose/hydromagnesite stromatolite bio-nanocomposite

et al. 2022

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Currently, researchers are focusing on the development of nano-additive preservatives during the worldwide COVID-19 pandemic. This research aimed to constitute a small sized preservative nano-formulation which emerges from the biopolymer carboxymethyl cellulose (a green stabilizing agent) and hydromagnesite stromatolite (a fossilized natural additive). In this study, we investigated the optimization of the experimental design of carboxymethyl cellulose/hydromagnesite stromatolite (CMC/HS) bio-nanocomposites using a green and one-step sonochemical method at room temperature. In addition, we constructed a mathematical model which relates the intrinsic viscosity with all operating variables, and we carried out statistical error analysis to assess the validity of the proposed model. The characterization and chemical functional groups of CMC/HS bio-nanocomposites were determined by different advanced techniques such as SEM, HRTEM, DLS, FTIR, XRD, and BET. The challenge test was used to show the preservative efficacy of CMC/HS bio-nanocomposites against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Candida albicans, and Aspergillus brasiliensis. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltrazolium bromide (MTT) assay was performed on L929 cells to evaluate the in vitro cytotoxicity of CMC/HS bio-nanocomposites. According to the results, we showed that the synthesized CMC/HS bio-nanocomposites have no cytototoxic effects on L929 fibroblast cells and could be considered to be an alternative green nano-additive preservative against pathogenic microorganisms.

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A Review of Sensor Technologies Applicable for Domestic Livestock Production and Health Management

Asmare

2022

Advances in Agriculture

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The world is running for the digitalization of social, economic, and political endeavors. As the world is getting into technologies of various streams of development, agriculture, especially livestock production, is also one of the areas of development that requires the application or use of emerging technologies. But knowledge and skill are relatively scanty, particularly in developing countries. Hence, it is vital to fill this gap of knowledge by compiling information and presenting it to a large audience for further research in the field. In the era of the advent of sensors for broader fields, it is important to consider the possible application of these technologies in rangeland condition assessment and animal production. The technologies are more relevant in the implementation of precisions farming practices of livestock including the individual animal behavior, grazing condition, health condition, and forage intakes. For grazing stock, it is vital to assess the status of both livestock grazing behavior and rangeland resource conditions. The rangeland resources are important components of livestock production throughout the world. Forages and pasture are dynamics in the abundance, species composition, and chemical composition as a result of environmental and management changes. The rangeland resources must be assessed and monitored for better management and utilization. Conventional assessments which include manual or mechanical counting, identification, and chemical composition are laborious and time-consuming. Under field conditions, not only grazing lands condition can be monitored using sensors but also is possible to understand the grazing behavior of animals for better management of grazing stock. To complement and or replace conventional techniques, it is vital to understand the current technologies such as sensors or biosensors. This review study is organized to increase awareness of the available technologies and their relevance regarding rangeland resources, particularly in tropical rangelands. In most cases, in the tropics, GPS systems are commonly used to assess only the rangeland status without considering the grazing stock. The review also elucidates that sensor technologies are important to detect livestock health conditions and movements at the field level in a rapid and easy way. However, like other technologies, sensors (biosensors) have limitations including accuracy of measurements and repetitive data accusations. Nevertheless, the review elucidates the use of sensor technologies and saves time and energy in animal production which otherwise could demand extensive energy and time.

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Biosensors: Modern Tools for Disease Diagnosis and Animal Health Monitoring

Cited by 3 publications

References 158 publications

Detection of viral antibodies in camel sera using magnetic particle spectroscopy

Detection of viral antibodies in camel sera using magnetic particle spectroscopy

Characterization, optimization, and evaluation of preservative efficacy of carboxymethyl cellulose/hydromagnesite stromatolite bio-nanocomposite

A Review of Sensor Technologies Applicable for Domestic Livestock Production and Health Management

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