Germacra-1,10Z,4E-dien-12,8α-olides fromMikania micrantha

Boeker, R.; Jakupovic, J.; Bohlmann, Ferdinand; Schmeda‐Hirschmann, Guillermo

doi:10.1055/s-2006-962638

Cited by 26 publications

(13 citation statements)

References 3 publications

(3 reference statements)

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“…In M. micrantha was isolated and identified eupalitin, eupafolin, luteolin (65) , mikanin, alpinetin, mikanin-3-O-sulfate (59) (Herz et al, 1975;Nicollier & Thompson, 1981;Boeker et al, 1987;Cuenca et al, 1988;Jiang et al, 2001). In the same specie was identified 3,4',5,7-tetrahydroxy-6-methoxyflavone-3-O-β-D-glucopyranoside by Huang et al (2009).…”

Section: Phytosterols/terpenoidsmentioning

confidence: 99%

Genus Mikania: chemical composition and phytotherapeutical activity

Rufatto¹,

Gower²,

Schwambach³

et al. 2012

Rev. bras. farmacogn.

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Abstract:The genus Mikania ranks high in the list of best-selling natural products in the world. Its main distribution is in South America, but some species are found in Asia, North America and Africa. It is used for treating fever, rheumatism, colds and respiratory diseases, as well as snake bites and scorpion stings, due to its broad spectrum of action. There are approximately 430 species of this genus and only 12% have been studied, highlighting their chemical and pharmacological diversity. The main chemical groups are: coumarins and derivatives, sesquiterpenes, sesquiterpenes lactones, diterpenes, phytosterols/terpenoids and flavonoids. This review aims to supply useful references for scientists interested in natural products and the search for new compounds, from over the 300 already described for the genus.

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Section: Phytosterols/terpenoidsmentioning

confidence: 99%

Genus Mikania: chemical composition and phytotherapeutical activity

Rufatto¹,

Gower²,

Schwambach³

et al. 2012

Rev. bras. farmacogn.

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“…However, it has been widely adapted as a medicinal plant, certainly because of the good accessibility, but probably also due to its medicinal effects. Its methanol and/or water extracts show antibacterial activity against Escherichia coli, Bacillus subtilis, Staphylococcus aureus, Proteus vulgaris and Enterobacter aerogenes (Cambie and Ash, 1994;Ghosh et al, 2008) and sesquiterpene lactones with activity against Staphylococcus aureus and Candida albicans have been isolated as well (Boeker et al, 1987;Facey et al, 1999;Bakir et al, 2004;Huang et al, 2004), some also showing cytotoxic activity (Cambie and Ash, 1994). The plant collection localities were divided into five major areas: village, garden (home gardens, forest gardens and coconut plantations), wayside, primary-and secondary forest and beach.…”

Section: Distribution Habitat and Habit Of The Medicinal Speciesmentioning

confidence: 99%

Medicinal plant use in Vanuatu: A comparative ethnobotanical study of three islands

Bradacs

Heilmann

Weckerle

2011

Journal of Ethnopharmacology

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“…In addition, it has been attracted the attention of natural products chemists because of its antibacterial, antitumor, cytotoxic, analgesic, inflammatory, antiproliferative, and phytotoxic activities [5]–[13]. By consulting literatures, sterols [14], [15], diterpenes [15], polyphenols [16], flavonoids [17]–[19], and sesquiterpene lactones [4], [14], [20] have been isolated from M. micrantha . However, the antimicrobial constituents were ambiguous, though mikanolide and dihydromikanolide as antimicrobial ingredient of M. micrantha were reported.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Constituents of the Leaves of Mikania micrantha H. B. K

et al. 2013

PLoS ONE

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BackgroundTo isolate plant-derived compounds with antimicrobial activity from the leaves of Mikania micrantha, to determine the compounds configuration, and to evaluate their antimicrobial activity against eight plant pathogenic fungi (Exserohilum turcicum, Colletotrichum lagenarium, Pseudoperonispora cubensis, Botrytis cirerea, Rhizoctonia solani, Phytophthora parasitica, Fusarium solani, and Pythium aphanidermatum,) and four plant pathogenic bacteria (gram negative bacteria: Ralstonia dolaanacearum, Xanthomonas oryzae pv. Oryzae, Xanthomonas Campestris pv. Vesicatoria, and Xanthomonas campestris pv. Citri), and four bacteria (gram positive bacteria: Staphyloccocus aureus, Bacillus subtilis, Micrococcus luteus, and Bacillus cereus).Methods and ResultsAntimicrobial constituents of the leaves of M. micrantha were isolated using bioactivity- guided fractionation. The antifungal activity of the isolated compounds was evaluated by the inhibit hypha growth method and inhibit spore germination method. Characterization of antibacterial activity was carried out using the minimum inhibitory concentrations (MICs) and the minimum bactericidal concentrations (MBCs). MIC and MBC were determined by the broth microdilution method. Six compounds – deoxymikanolide, scandenolide, dihydroscandenolide, mikanolide, dihydromikanolide, and m - methoxy benzoic acid – have been isolated from leaves of Mikania micrantha H. B. K. Deoxymikanolide, scandenolide, and dihydroscandenolide were new compounds. The result of bioassay showed that all of isolated compounds were effective against tested strains and deoxymikanolide showed the strongest activity.Conclusions and SignificanceThe leaves of M. micrantha may be a promising source in the search for new antimicrobial drugs due to its efficacy and the broadest range. Meanwhile, adverse impact of M. micrantha will be eliminated.

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Germacra-1,10Z,4E-dien-12,8α-olides fromMikania micrantha

Abstract: The aerial parts of MIKANIA MICRANTHA from a collection in Paraguay gave, in addition to mikanolide, deoxymikanolide, and miscandenin, five new germacranolides all derived from 14,15-dihydroxygermacra-1(10) E,4 Z-dien-12,8alpha-olide.

Cited by 26 publications

References 3 publications

Genus Mikania: chemical composition and phytotherapeutical activity

Genus Mikania: chemical composition and phytotherapeutical activity

Medicinal plant use in Vanuatu: A comparative ethnobotanical study of three islands

Antimicrobial Constituents of the Leaves of Mikania micrantha H. B. K

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