Genotype distribution characteristics of high-risk human papillomaviruses in women from Shanghai, China

Abstract

High-risk human papillomaviruses (HPVs) are highly prevalent worldwide, and HPV genotype distribution varies regionally. Molecular surveys of HPVs are important for effective HPV control and prevention. Fifteen high-risk HPV strains (16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 68) and six low-risk HPV strains (HPV6, 11, 42, 43, 44, CP8304) were detected by cervical cytology from 10 501 subjects. High-risk HPVs, low-risk HPVs, and both high- and low-risk HPVs were detected in 14·5%, 2·8%, and 2·4% of cases, respectively. Of 1782 subjects with high-risk HPV infection, 75·5%, 18·1%, and 6·4% were infected with one, two, and ⩾3 strains of high-risk HPVs, respectively. HPV52, HPV16, and HPV58 were the top three most dominant high-risk HPV genotypes in our population with positivity rates of 23·0%, 17·7% and 16·9%, respectively. Multiple infection was common, with significantly higher co-infection rates of HPV58/HPV33 (12·9%) and HPV58/HPV52 (11·3%). Further data comparisons showed that HPV genotype distribution varied markedly between domestic and international regions. In conclusion, a monolithic vaccination strategy is obviously impractical, and regional HPV surveillance is essential to optimize current HPV control and prevention.

Distribution characteristics of different human papillomavirus genotypes in women in Wuhan, China

“…HPV 52 is the most common HR‐HPV genotype, followed by HPVs 16, 58, 39, and 51. These findings are partly consistent with the data on HPV prevalence in Asian regions such as Japan, Taiwan and Shanghai, where the most common HPVs are ranked HPVs 52, 16, 51, 35, and 18 and HPVs 52, 16, 58, 53, and 33 . Given that China covers a vast territory, the prevalence patterns differ regionally, even among different regions of mainland China.…”

“…5 HPVs preferentially infect the mucosa of the genitals, upper-respiratory tract, and the skin, 6 and they are recognized as important pathogenic factors of cervical cancer and precancerous lesions. 6,7 Based on the association of HPV with cervical cancer or the risk of carcinogenesis, all HPV genotypes can be divided into different subgroups of mucosal HPVs: high-risk types of HPVs (HR-HPV), such as HPVs 16,18,31,33,35,39,45,51,52,56,58,59,68,73,and 82, which are classified as carcinogenic to humans 5,8 ; low-risk types of HPVs (LR-HPV), such as HPVs 6,11,28,32,40,42,43,44,54,55,57,61,62,71,72,74,81,83,84,86,87, and 89; probable/possible HR-HPVs (pHR-HPV), such as HPVs 68, 26, 53, 66, 82, 70, 67, and 73. 5 The HR-HPVs are the causes of approximately 5% of all cancers in humans and one-third of all virus-induced tumors.…”

“…15 Previous epidemiological studies have shown that the prevalence of HPV infection and genotype distribution differs among regions, 16,17 and a molecular epidemiological study of HPVs could provide useful data to support reasonable local vaccination strategies. 18 There is a great need for more local data on HPV infections and genotype distribution in women of different populations, which can then be used to evaluate the efficacy of the HPV vaccine in different populations 19 and contribute to the development of cervical cancer screening. 20 China covers a large territory and has many ethnic groups, and the distribution characteristics of HPVs in different regions are not the same.…”

“…including 14 HR-HPV types:HPVs 16,18,31,33,35,39, 45, 51, 52, 56, 58, 59, 66, and 68; one pHR-HPV type: HPV 53; 5 LR-HPV types: HPVs 6, 11, 42, 43, 44; and 81, equivalent to CP8304. In the final step of this process, different genotypes were identified by adding NBT/BCIP solution to display the results, with a clearly visible indigo dot indicating the positive presence of HPV.…”

Characteristics of carcinogenic human papillomavirus infection in Suzhou: Epidemiology, vaccine evaluation, and associated diseases

“…In most previous studies, such as Chaozhou [Chen et al, ], Macao [Yip et al, ], Shanghai [Gu et al, ], and Zhejiang [Ye et al, ], as well as in Japan [Sasagawa et al, ], HPV‐52 was the most commonly identified type. While in some other reports from Henan [Shen et al, ], French [Casalegno et al, ] America [Wheeler et al, ], and other populations [Vinodhini et al, ; Wu et al, ], HPV‐16 was the most frequent type.…”