Characteristics of carcinogenic human papillomavirus infection in Suzhou: Epidemiology, vaccine evaluation, and associated diseases

Abstract

Human papillomavirus infection is a major health problem and caused substantial benign and malignancy diseases among female and male worldwide. We aim to investigate the epidemiology of high-risk human papillomavirus (HR-HPV) and related diseases in Suzhou population. As well as evaluating the potential benefit of a nine-valent HPV vaccine (regardless of HPV-6 and -11) in Suzhou. A total of 40,108 people aged 13-89 years were retrospectively examined by database retrieval from 2010 to 2015. Thirteen genotypes (16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 66) of HR-HPV were detected using Tellgenplex™ xMAP™ HPV DNA Test assay. The overall prevalence of HR-HPV was 21.1%, the female and male account for 96.4% and 3.6%, respectively. The infection rate among male (25.6%, 367/1,432) was significantly higher than that among female (20.9%, 8,100/38,676), X = 17.341 (P < 0.001), with OR = 1.293, 95% CI (1.146-1.460). The five most frequent HR-HPV genotypes were HPV-16 (5.12%), -52 (5.07%), -58 (3.02%), -39 (2.00%), and -18 (1.74%). HR-HPV infection rate was peak in person aged <20 years, and second higher in person aged 51-60 years. Infection modes as HPV-16, -18, -31, -33, -45, -52, -58 alone or mixed accounted for 63.2%. The top three prevalent diseases in HR-HPV infected women were cervicitis, vaginitis, and cervical lesions, and in men were verruca, urethritis, and balanitis, respectively. This is the first study to demonstrate HPV infection status in Suzhou population. Both women and men had a large burden of HPV infection. The nine-valent HPV prophylactic vaccines may potentially prevent 63.2% HR-HPV infection in Suzhou. J. Med. Virol. 89:895-901, 2017. © 2016 Wiley Periodicals, Inc.

Rising Mortality Rate of Cervical Cancer in Younger Women in Urban China

“…Administration of HPV vaccine induces durable anti-HPV responses and prevents HPV infection. 20,32 Currently, HPV vaccines of 2-and 4-valent are available in China, and a 9valent vaccine has been available in parts of China since May 2018. However, awareness and willingness to receive HPV vaccination remain low.…”

“…19 On the other hand, however, the prevalence of human papillomavirus (HPV) infection remains at a high level in both urban and rural China. 20,21 Our study's purpose was to examine trends in cervical cancer mortality from 1987 to 2015 in China, among each 5year age group, comparing urban and rural rates.…”

Human Papillomavirus Type 16 E1 Mutations Associated with Cervical Cancer in a Han Chinese Population

“…For HPV genotyping, the Tellgenplex™ HPV DNA Test which is a suspension bead array method for identifying HPV types was used. The experimental protocol has been described in a previous study 22. Human β-globin was used as an internal control for each reaction.…”

Association of Human Papillomavirus Type 16 Long Control Region Variations with Cervical Cancer in a Han Chinese Population

“…For HPV genotyping, the Tellgenplex™ HPV DNA Test, which is a suspension bead array method for identifying HPV types, was used. The experimental protocol has been described in a previous study [29]. Human β-globin was used as an internal control for each reaction.…”