Gender differences in relationships between body composition components, their distribution and bone mineral density: a cross-sectional opposite sex twin study

Makovey, Joanna; Naganathan, Vasi; Sambrook, Philip N.

doi:10.1007/s00198-005-1841-4

Cited by 70 publications

(66 citation statements)

References 50 publications

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“…Why such an effect would be evident in the spine but not the hip remains unclear, however the relative composition in terms of trabecular versus cortical bone varies at these sites and we and others have previously reported this differential effect on other bone related endpoints. For example we have shown that total body fat mass is related to lumbar spine BMD but not hip BMD in younger subjects [20].…”

Section: Discussionmentioning

confidence: 81%

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Association between serum cholesterol and bone mineral density

Makovey

Chen

Hayward

et al. 2009

Bone

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123

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Section: Discussionmentioning

confidence: 81%

“…The hospital's Human Research Ethics Committee approved the study. Some of these twin data have been previously reported [19][20][21]. After providing written informed consent, each twin was interviewed separately in accordance with a standard questionnaire to collect demographic, lifestyle and medical history data.…”

Section: Subjectsmentioning

confidence: 99%

Association between serum cholesterol and bone mineral density

Makovey

Chen

Hayward

et al. 2009

Bone

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123

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“…Only a few studies have investigated the association of bone mineral measures with body composition components adjusted for body size or their distribution (such as centrality indices). 130 However, recent research suggests that obesity may accelerate bone loss. 131 Deng et al showed, in two large population samples, that the bone strengthening effects of a heavy body were not due to fat but to elevated muscle mass, which increases bone density.…”

Section: -120mentioning

confidence: 99%

The impact of obesity on the musculoskeletal system

et al. 2007

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Obesity is associated with a range of disabling musculoskeletal conditions in adults. As the prevalence of obesity increases, the societal burden of these chronic musculosketelal conditions, in terms of disability, health-related quality of life, and health-care costs, also increases. Research exploring the nature and strength of the associations between obesity and musculoskeletal conditions is accumulating, providing a better understanding of underlying mechanisms. Weight reduction is important in ameliorating some of the manifestations of musculoskeletal disease and improving function.

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“…However, even this issue is controversial. Makovey et al [12] demonstrated that in both genders BMD is mostly affected by lean body mass, with positive effect of fat mass exclusively in women under 50 years old, but not in older ones. In contrast, Yoo et al [13] found negative effects of body fat on BMD exclusively in premenopausal women.…”

Section: Introductionmentioning

confidence: 99%

Relationships between bone mineral density and new indices of body composition in young, sedentary men and women

Kęska¹,

Lutosławska²,

Bertrandt

2018

Ann Agric Environ Med.

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Introduction. Data concerning the relationship between body fat and BMD are equivocal since both positive and negative effects have been noted. Recently, the index of fat mass (IFM) representing subjects with different body fat and similar lean mass and index of lean mass (ILM) representing subjects with different lean body mass and similar body fat, have been used to evaluate body composition effect on BMD in middle-aged women. This study aimed at determination of ILM and IFM association with BMD in young men and women. Materials and methods. A total of 212 university students of Public Health (125 women and 87 men) participated in the study. Body composition was determined by the bioelectrical impedance method (BIA) using BC 418 MA equipment (Tanita Co., Japan). Fat mass and fat free mass were used to calculate ILM and IFM. Bone mineral density was measured on the wrist of the non-dominant hand using the DEXA method and EXA 3000 equipment (HFS Ltd., Korea). BMD was evaluated using Z-score, with values lower than -2.0 indicating inadequate BMD for subject chronological age. Results. Exclusively in women, IFM was markedly and positively correlated with Z-score (r=0.366, P<0.001). In both genders, a significant relationship was found between ILM and Z-scores (r=0.420; p<0.001 and r=0.220; p<0.02 in men and women, respectively). Women with lower than median IFM but similar ILM, were characterized by significantly lower Z-scores vs. women with higher IFM (-1.016 vs. -0.512; p<0.001). Irrespective of gender, participants with higher ILM but similar IFM, were characterized by markedly higher Z-score vs. their counterparts with low ILM. Conclusions. The use of IFM and ILM in the present study, allowed the observation that in young adults lean body mass was associated with BMD, regardless of gender, while fat mass is significant for bone mineral density only in women.

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Gender differences in relationships between body composition components, their distribution and bone mineral density: a cross-sectional opposite sex twin study

Abstract: Background: Numerous studies indicate that bone mineral density (BMD) is closely related to body mass and its components. Most studies have examined these relationships in women with little attention given to how these relationships differ by gender.

Cited by 70 publications

References 50 publications

Association between serum cholesterol and bone mineral density

Association between serum cholesterol and bone mineral density

The impact of obesity on the musculoskeletal system

Relationships between bone mineral density and new indices of body composition in young, sedentary men and women

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