The impact of obesity on the musculoskeletal system

Anandacoomarasamy, Ananthila; Caterson, Ian D.; Sambrook, Philip N.; Fransen, Marlene; March, Lyn

doi:10.1038/sj.ijo.0803715

Cited by 352 publications

(293 citation statements)

References 154 publications

(138 reference statements)

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“…9,32 An earlier study indicated that obesity has a significant impact on the musculoskeletal system. 33 Obese individuals are more likely to have weak back or abdominal muscles because of their additional body weight. 34 Thus, there is a greater likelihood of increased stress on the musculoskeletal system; in addition, their own strength has decreased as they have gained additional mass.…”

Section: Discussionmentioning

confidence: 99%

Association between obesity and injury among Taiwanese adults

Hu¹,

Chou²,

Chou³

et al. 2009

Int J Obes

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Background: The prevalence of obesity and injury has increased in Asian countries, but the relationship between obesity and injury is less well established. The aim of this study is to evaluate the relationship between body mass index (BMI), the occurrence of injury, and the injury-related expenditure among Taiwanese adults. Design: Retrospective cohort study. Methods: Our study sample consisted of 12 520 adults aged 18 years or older from the 2001 National Health Interview Survey, who had consented to the linking of their survey responses with their National Health Insurance claims records. Cox proportional hazards regression and a two-part model were used for analysis. Results: The results show that there was a positive association between BMI and injury. Relative to normal-weight adults, the hazard ratio (HR) of injury were 1.21 (95% confidence interval (CI): 1.08-1.36) for obese class II adults and 1.11 (95% CI: 1.05-1.18) for obese class I adults, after adjusting for confounding factors. The HR of sustained strain/sprain rose to statistical significance (Po0.001) among persons with a higher BMI. For obese class II and I adults, the adjusted injury-related expenditure levels were 33.4 and 15.6%, respectively, greater than those of normal-weight adults. Conclusions: There was a strong positive relationship between high BMI and increased risk of injury as well as higher injuryrelated expenditure. Specifically, a high BMI was associated with an increased risk of strain/sprain. Low-intensity flexibility, strength, and balance training programs should be considered in addition to weight reduction programs to prevent strain/sprain for obese adults.

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Section: Discussionmentioning

confidence: 99%

Association between obesity and injury among Taiwanese adults

Hu¹,

Chou²,

Chou³

et al. 2009

Int J Obes

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“…The prevalence of musculoskeletal symptoms in the knees of obese people has been well-established in the literature (5,21). It has been demonstrated that weight gain is associated with adverse effects on the knees, such as pain, stiffness and functional changes (22).…”

Section: Discussionmentioning

confidence: 99%

“…A higher prevalence of musculoskeletal symptoms affecting mainly the lower limbs has been reported in obese individuals (4,5). Some of these symptoms manifest as joint discomfort caused mainly by excess weight, which can overload the musculoskeletal structures responsible for stabilizing and moving the body (6).…”

Section: Introductionmentioning

confidence: 99%

“…Some of these symptoms manifest as joint discomfort caused mainly by excess weight, which can overload the musculoskeletal structures responsible for stabilizing and moving the body (6). Obesity has been associated with significant impairment in mobility (7) and several musculoskeletal disorders, which can lead to disability and poor quality of life (5,6) and result in high direct and indirect healthcare economic costs (8,9).…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of musculoskeletal symptoms in obese patients candidates for bariatric surgery and its impact on health related quality of life

Calenzani

Santos

Wittmer

et al. 2017

Arch. Endocrinol. Metab.

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Objective: This study was designed to identify the major musculoskeletal symptoms of individuals with obesity, to assess their health-related quality of life, and to evaluate the correlation between the musculoskeletal symptoms and the individuals' health-related quality of life. Materials and methods: Cross-sectional study. Instruments used: "Nordic Musculoskeletal Questionnaire" and "The Medical Outcomes Study 36-Item Short-Form Health Survey (SF-36)" . Results: In total, 41 subjects were evaluated, of which 90.15% were female. The mean age of the subjects was 40.78 ± 9.85 years and their mean body-mass index was 46.87 ± 8.08. All subjects reported musculoskeletal pain in at least one anatomical region and 80.49% had pain in three or more regions. The activity limitations due to pain were reported by 75.61% of them. The most affected regions by pain were the ankles and/or feet, lower back, knees and wrists/hands/fingers. The most associated regions with activity limitations due to pain were the ankles and/or feet, knees and lower back. The presence of pain showed a negative correlation with the domains physical functioning (PF), role-physical (RP) and body pain (BP). The activity limitations showed a negative correlation with the domains PF, BP, social functioning (SF) and role-emotional (RE). Conclusion: Our data showed a high prevalence of musculoskeletal pain and limitation in activities due to pain in obese subjects. The musculoskeletal symptoms had negative correlations with physical and mental components of the health-related quality of life, highlighting the importance of ensuring that patients with obesity have access to interdisciplinary care, for the prevention and rehabilitation of musculoskeletal disorders. Arch Endocrinol Metab. 2017;61(3):319-25.

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“…2 Consequences of the obesity epidemic are an increase in the occurrence of cardiovascular diseases, diabetes, musculoskeletal disorders, such as osteoarthritis of knee and hip, and certain types of cancers. 3,4 Cardiovascular diseases are the main cause of death worldwide and diabetes has rapidly grown into a global epidemic. 5 Therefore, overweight is a serious threat to public health.…”

Section: Introductionmentioning

confidence: 99%

Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study

et al. 2009

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Background: As nuclear receptors and transcription factors have an important regulatory function in adipocyte differentiation and fat storage, genetic variation in these key regulators and downstream pathways may be involved in the onset of obesity. Objective: To explore associations between single nucleotide polymorphisms (SNPs) in candidate genes from regulatory pathways that control fatty acid and glucose metabolism, and repeated measurements of body mass index (BMI) and waist circumference in a large Dutch study population. Methods: Data of 327 SNPs across 239 genes were analyzed for 3575 participants of the Doetinchem cohort, who were examined three times during 11 years, using the Illumina Golden Gate assay. Adjusted random coefficient models were used to analyze the relationship between SNPS and obesity phenotypes. False discovery rate q-values were calculated to account for multiple testing. Significance of the associations was defined as a q-value p0.20. Results: Two SNPs (in NR1H4 and SMARCA2 in women only) were significantly associated with both BMI and waist circumference. In addition, two SNPs (in SIRT1 and SCAP in women only) were associated with BMI alone. A functional SNP, in IL6, was strongly associated with waist. Conclusion: In this explorative study among participants of a large population-based cohort, five SNPs, mainly located in transcription mediator genes, were strongly associated with obesity phenotypes. The results from whole genome and candidate gene studies support the potential role of NR1H4, SIRT1, SMARCA2 and IL6 in obesity. Although replication of our findings and further research on the functionality of these SNPs and underlying mechanism is necessary, our data indirectly suggest a role of GATA transcription factors in weight control.

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The impact of obesity on the musculoskeletal system

Cited by 352 publications

References 154 publications

Association between obesity and injury among Taiwanese adults

Association between obesity and injury among Taiwanese adults

Prevalence of musculoskeletal symptoms in obese patients candidates for bariatric surgery and its impact on health related quality of life

Genetic variations in regulatory pathways of fatty acid and glucose metabolism are associated with obesity phenotypes: a population-based cohort study

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