Galli‐Galli disease responsive to isotretinoin treatment

Abstract

A 58-year-old woman presented with a 15-year history of an itchy skin eruption that started on her trunk and subsequently spread to her extremities. She reported having had multiple

Galli–Galli disease successfully treated with alitretinoin

“…3 Additional features include comedo-like dark follicular dots and peri-oral pitting scars, 4 although these features are clinically not observed in our case nor mentioned in most of the earlier reports. [2][3][4] In our case, histology revealed granulomatous inflammation alongside perifollicular fibrosis and probably reflects a foreign body response to earlier epithelial invagination or comedo rupture. Reported therapeutic options include topical and systemic corticosteroids, topical retinoids, cyclosporine and UVB-phototherapy, although most of these interventions have shown only limited success.…”

“…Reported therapeutic options include topical and systemic corticosteroids, topical retinoids, cyclosporine and UVB-phototherapy, although most of these interventions have shown only limited success. [2][3][4][5] Others showed good results with ablative laser treatment up to 12-month follow-up. 6 Acitretin (25 mg/day) combined with topical corticosteroids showed only a short-term partial improvement.…”

“…It is an autosomal dominant genodermatosis with variable penetrance, resulting from mutations in the KRT5, POFUT1 and POGLUT1 genes. 2 Galli-Galli disease is characterized by reticulated hyperpigmentation in combination with pruritic erythematous papules, which predominantly affect the flexures. 3 Additional features include comedo-like dark follicular dots and peri-oral pitting scars, 4 although these features are clinically not observed in our case nor mentioned in most of the earlier reports.…”

“…After increasing the isotretinoin dose to 40 mg/day, the patient reported side-effects and ceased treatment. 2 Alitretinoin (9-cis retinoic acid) is a vitamin A derivate. It is approved for chronic hand eczema and was shown to have immune-modulatory, anti-proliferative and anti-inflammatory effects.…”

Low dose of isotretinoin: A comprehensive review

“…Dupuy et al reported a middle-aged woman with Galli-Galli disease who showed improvement of her symptoms after 6 weeks of lowdose isotretinoin (30 mg/day), with no relapse on discontinuation after 1 month (Dupuy, Alexanian, & Hsiao, 2018). The patients showed vellus hair involvement presenting in an isolated facial papules (FP).…”