Low dose of isotretinoin: A comprehensive review

Abdelmaksoud, Ayman; Lotti, Torello; Anadolu, Ranâ; Goldust, Mohamed; Ayhan, Erhan; Dave, Dharmendra Dineshchandra; Vestita, Michelangelo; Ebik, Berat; Gupta, Mrinal

doi:10.1111/dth.13251

Cited by 21 publications

(28 citation statements)

References 115 publications

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“…A study conducted by Karadag et al showed that isotretinoin may lead to a slight reduction in pituitary hormone and testosterone levels [21]. Likewise, Rademaker et al also observed a marked reduction in serum testosterone levels as a result of isotretinoin therapy [22].…”

Section: Discussionmentioning

confidence: 99%

Untitled

2020

Our Dermatol Online

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Acitretin is a second-generation oral retinoid used by dermatologists for the treatment of dermatological disorders such as psoriasis, pityriasis rubra pilaris, and lichen planus [1]. Acitretin may cause some common side effects such as dry skin and mucosa, hyperlipidemia, muscle and joint pain, and hepatitis [2]. Erectile dysfunction is defined as the inability to achieve and maintain a penile erection adequate for satisfactory sexual intercourse. Erectile dysfunction may be due to various reasons, including psychogenic and organic factors, endocrine disorders, and drug use [3]. Data on the effect of acitretin on sexual function is limited. The literature provides no studies that would investigate whether acitretin causes erectile dysfunction in humans. Therefore, in this study, we aimed at investigating whether patients taking acitretin develop erectile dysfunction. MATERIALS AND METHODS The study included 40 male patients who presented to the Dermatology Polyclinic of Okmeydanı Training and Research Hospital between October 2014 and April 2016 and started treatment with acitretin for various dermatological disorders. Exclusion criteria included psychogenic and psychiatric disorders, diabetes mellitus, ABSTRACT Background: Acitretin is a second-generation oral retinoid compound used as a treatment option for various dermatological disorders. The effects of the drug on erectile function have not been fully determined yet. We aimed at investigating whether patients taking acitretin develop erectile dysfunction (ED). Materials and Methods: The study included 40 male patients who presented to the Dermatology Polyclinic of Okmeydanı Training and Research Hospital between October 2014 and April 2016 and started treatment with acitretin. Exclusion criteria included psychogenic and psychiatric disorders, neurological disorders such as multiple sclerosis, diabetes mellitus and endocrine disorders, arteriogenic and venous disorders, alcohol and tobacco use, penile disorders, obesity, a history of drug use, a score of above 10 points in the Beck Depression Inventory (BDI), hyperlipidemia, and an age above 65 years. Having obtained the informed consent, the patients were asked to complete the International Index of Erectile Function (IIEF) questionnaire before and after three months of therapy. The patients were evaluated by calculating their scores and a statistical analysis was performed. Results: A total of 40 patients were included in the study. A comparison of the IIEF scores before and after three months of therapy revealed that the scores were significantly lower after three months of therapy (P < 0.0001). ED was diagnosed in 30 patients (75%) at the beginning of therapy and in 35 patients (87.5%) after three months of therapy. A comparison of baseline and 3-month IIEF grades revealed that the number of patients in the second group was significantly greater after three months of therapy with the drug (P = 0.001). When the percentage of patients with erectile dysfunction at the baseline and after three months of ther...

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Section: Discussionmentioning

confidence: 99%

Untitled

2020

Our Dermatol Online

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“…Isotretinoin with its anti-inflammatory and immunomodulation characteristics has been approved for the treatment of comedonal acne [ 6 ]. The adverse side effects of isotretinoin include but are not limited to rash, teratogenicity and dry mouth [ 7 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

Concurrent Serotonin Syndrome and Prolong QT Interval Induced by Paroxetine Overdose With Isotretinoin

Al-Radideh¹,

Chan²,

Gupta³

et al. 2021

Cureus

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“…The retinoids are a group of drugs that are derived from vitamin A or are chemically related to it (Abdelmaksoud et al, ; Altıntaş Aykan & Ergün, ; Tugrul Ayanoglu, Demirdag, Yalici Armagan, & Bezirgan, ). Retinoids play a major role in functioning of the body including vision, cell proliferation regulation and differentiation, growth of bones, immunity, and tumor suppressor genes activation (Ahmad, ; Brzezinski, Borowska, Chiriac, & Smigielski, ; On & Zeichner, ).…”

Section: Introductionmentioning

confidence: 99%

Alopecia areata and isotretinoin; coincidence or causal relation

Gupta¹,

Lotti

Goldust

2020

Dermatologic Therapy

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Isotretinoin is a safe and useful medication for acne management. Adverse effects are mostly related to cutaneous and mucous membranes. We present a case of a 24‐year‐old female patient who was on treatment with isotretinoin for acne vulgaris Grade 4. After 6 months of treatment, the patient presented with localized patch of hair loss. Beginning of alopecia areata in patients with acne vulgaris could be regarded as a side effect of retinoids due to anti‐acne therapy. The exact mechanism by which retinoids cause hair loss is not known.

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Low dose of isotretinoin: A comprehensive review

Cited by 21 publications

References 115 publications

Untitled

Untitled

Concurrent Serotonin Syndrome and Prolong QT Interval Induced by Paroxetine Overdose With Isotretinoin

Alopecia areata and isotretinoin; coincidence or causal relation

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