Frequency & pattern of malignancy in solitary thyroid nodule

Abstract

This cross sectional study done in the department of Banghabandhu Sheikh Mujib Medical University and Dhaka Medical College Hospital during the period of July 2005 to October 2007 to determine frequency & pattern of malignancy in solitary thyroid nodule. For this study, 118 patients who were diagnosed as a case of malignancy in solitary thyroid nodule by detailed history, clinical examination, thyroid hormone assay, ultrasonogram, thyroid scan, FNAC and histopathological examination, were collected. In this study majority of the patients were within 21-40 years of age. Frequency of solitary thyroid nodule is more in female with male female ratio 1: 2.11 Majority of the nodules were firm (72.03%), others were hard (16.95%) and cystic (11.02%). Malignant lesion was more common in hard nodule (70%). Most of the nodules were cold (66.10%) among them 25.6% cases were malignant, followed by warm (30.5%) and hot (3.3%). No malignancy was found in hot nodule. FNAC showed colloid nodule (44%), cellular follicular lesion (29.66%), papillary carcinoma (12.7%), colloid degeneration (4.2%) and medullary carcinoma (1.6%) Out of 118 patients, histopathologically non malignant were 96 (81.35%) and malignant were 22(18.65%). Among malignant cases, 16 (72.72%) cases were papillary carcinoma, 4 (18.18%) cases were follicular carcinoma and 2(9.1%) cases were medullary carcinoma. Key words: Solitary thyroid nodule, FNAC, Papillary carcinoma, Follicular carcinomaDOI: 10.3329/bjo.v15i1.4303 Bangladesh J of Otorhinolaryngology 2009; 15(1): 1-5

Histopathological Study of Thyroid Neoplastic Lesions in a Tertiary Care Hospital - A 5 Year Study

“…14,17 The peak age of incidence in our study was 40-49 years age group for benign neoplasms and 20-29 years age group for malignant neoplasms which is in accordance with the study of Gupta A et al (2016) who found 21-40 years age group as the peak age for thyroid diseases. 12 Islam et al (2009), showed the majority of the patients were within 21-40 years of age. 18 In our study, malignant lesions predominated over benign adenomas within the neoplastic category.…”

“…12 Islam et al (2009), showed the majority of the patients were within 21-40 years of age. 18 In our study, malignant lesions predominated over benign adenomas within the neoplastic category. Our findings in this regard are similar to the study of Abdulkader et al…”

Histopathological study of thyroid lesions and correlation with ultrasonography and thyroid profile in western zone of Rajasthan, India

“…Islam et al 2009, showed the majority of the patients were within 21-40 yrs of age. 6 Rangaswamy M, et al, studied 585 cases and age range was 11-70 years, mean age was 40.57 years.…”

“…Islam et al 2009, showed the majority of the patients were within 21-40 yrs of age. 6 Rangaswamy M, et al, studied 585 cases and age range was 11-70 years, mean age was 40.57 years. 7 The youngest patient in our study was a boy of 14 years and the oldest patients was a man of 85 years both with adenomatous goitre.…”

Malignancy in Solitary Cold Nodule Thyroid

“…3 Study conducted by Islam showed that about 66.10% thyroid nodule were cold nodule in their patients. 20 In the context of Graves' disease, a prospective study conducted on 245 patients showed that 35% had thyroid nodules and about 3.3% were malignant, mostly micro papillary carcinomas. 21 There are variable data regarding malignancy in cystic and solid nodules, some study showed very low incidence of malignancy in cystic nodules (0.5 -3%), whereas others have similar incidence in solid nodules.…”