Formulation development and evaluation of colonic drug delivery system of budesonide microspheres by using spray drying technique

Objective: The purpose of current study was to improve physicochemical properties such as micrometric, compressibility and solubility of linezolid (LNZ) by preparing crystallo-co-agglomerates (CCA) in the presence of polymer for the enhancement of overall physicochemical performance. Methods:The process of agglomeration involves the use of dichloromethane (DCM) as a good solvent and chloroform as bridging liquid were used to prepare agglomerates. Agglomerates were characterised in the solid state using several techniques such as Scanning electronic microscopy(SEM), Fourier transformation infrared spectroscopy (FTIR), X-ray powder diffraction analysis (XRPD) The agglomerates obtained were evaluated for micrometric, mechanical, deformation, compressibility and drug release properties.Results: It was found that micrometric properties and dissolution characteristics of agglomerates were significantly improved than that of pure linezolid. Solubility was found to be increased than pure linezolid. The solubility of crystallo co-agglomerates was found an increase in 5 fold 3 fold and 3.7 fold for PVPK30 (0.5%), PVPK30 (0.25%) and PVPK30 (0.75%) respectively. The angle of repose for all batches was found between 22 ° to 30 °Carrs index was between 12.27±0.6 to 18.73±0.4 and Hausners ratio Near to 1, indicated good flow ability of agglomerates. The time required for drug release over a period of 60 min, is as LA1>LA2>LA3. LA3 shows fast drug release than LA1 and LA2, due to solubilization of drug due to more concentration of PVPK30 and less concentration of talc.Conclusion: Based on the above results, it was revealed that CCA of linezolid prepared with DCM and HPMC (Hydroxypropyl methyl cellulose)/PEG (Polyethylene glycol)/PVP (Polyvinylpyrrolidone) K30 exhibited improved micrometric properties, compressibility and in addition to improving solubility and dissolution rate.

show abstract

“…The percentage drug content was calculated using following formula given below. All analyses were carried out in triplicate [17].…”

Section: Process Yield and Drug Contentmentioning

confidence: 99%

Improvement of Micromeritic, Compressibility and Solubility Characteristics of Linezolid by Crystallo-Co-Agglomeration Technique

Kadam

Patil

2017

Int J App Pharm

View full text Add to dashboard Cite

show abstract

“…After the preparation of nanoparticles, they are collected, dried and weighed over electronic balance and percentage yield was calculated by formula. 21 Weight of Nanoparticles Percentage yield 100 Weight of polymers Weight of drug = × + Determination of drug entrapment efficiency Weighed 10 mg samples of drug-loaded nanoparticles and then dissolved in 10 ml of methanol under sonication for 1 hr. The sample have centrifuged at a high speed of 9000 rpm for 30 min and the supernatant liquid was analysed for non-bound drug in UV spectrophotometer at 276 nm.…”

Section: Determination Of Percentage Yieldmentioning

confidence: 99%

Formulation and Evaluation of Eudragit L- 100 based Nanoparticles of Senna for Treatment of Constipation

Pawar¹,

Tapkir²,

Rao³

et al. 2022

IJPI

View full text Add to dashboard Cite

Background:The pharmaceutical industries are keen in development of new herbal bioactive molecules with an improved effect and less toxicity in order to replace synthetic drugs. Constipation is the most prevalent medical concerns. It's estimated that one in five adults worldwide suffers from constipation. Hence, the demand of herbal laxatives is increasing worldwide. The purpose of this research work was to develop Senna nanoparticles with the help of Eudragit L100 an enteric coating polymer to provide site specific activity and to prevent degradation of Senna in acidic environment. Materials and Methods: Senna loaded nanoparticles were prepared by using emulsion solvent evaporation method. Different formulation has been formulated with varying concentration of Eudragit L-100 and constant aqueous and organic phase ratio (1:9). Drug and polymer compatibility study was analysed by FTIR. The prepared formulation was characterized by melting point, particle size, zeta potential, polydispersity index, vesical morphology and in-vitro drug release. Results: All the formulation batches shows particle size between 380.61 -1061.71nm. The zeta of optimized batch (F5) was found to be -23.75mV. Entrapment efficiency of the entire prepared formulation batch in between 3.16±0.31-55.18±0.35%. The in-vitro drug release shows maximum drug release i.e. 61.03% in 8 hrs which shows that release of drug prolonged and site specific due to use of enteric coated polymer Eudragit L100. Conclusion:The developed Senna loaded nanoparticles can provide site specific drug delivery. The polymer used in Senna Nanoparticles formulations shows efficient and targeted drug release as well as reduction in dose, dosing frequency and side effects.

show abstract

“…The rapid evaporation of the solvent impacts the resulting particles in terms of density, size and morphology, and these characteristics are also influenced by the formulation composition and the process parameters (Vo et al 2013). Optimization of the parameters involved in spray drying is therefore highly significant, including inlet and outlet temperature, atomization rate, the rate of feed transfer and on /off spraying periods (Shendge and Sayyad 2013).…”

Section: Spray Dryingmentioning

confidence: 99%

Recent solubility and dissolution enhancement techniques for repaglinide a BCS class II drug: a review

Albetawi¹,

Abdalhafez²,

Abu‐Zaid³

et al. 2021

PHAR

View full text Add to dashboard Cite

Repaglinide is an oral blood-glucose-lowering drug used to manage type-2 diabetes mellitus by lowering post-prandial glucose by stimulating insulin secretion from pancreatic beta cells. According to the biopharmaceutical classification system, repaglinide falls under the class II category. For such drugs, limited solubility and poor dissolution rate are the major hurdles to overcome by formulation scientists, as they hinder drug absorption and lead to inadequate therapeutic effects. Therefore, this review aims to discuss in depth the various approaches investigated in the past five years to improve the solubility and dissolution of orally administered repaglinide: namely, solid dispersion, co-amorphous technology, cyclodextrin complexation, phospholipid complexes and polymeric micelles, nanocrystals, nanosuspensions and nanofibers.

show abstract

Formulation development and evaluation of colonic drug delivery system of budesonide microspheres by using spray drying technique

Cited by 5 publications

References 6 publications

Improvement of Micromeritic, Compressibility and Solubility Characteristics of Linezolid by Crystallo-Co-Agglomeration Technique

Improvement of Micromeritic, Compressibility and Solubility Characteristics of Linezolid by Crystallo-Co-Agglomeration Technique

Formulation and Evaluation of Eudragit L- 100 based Nanoparticles of Senna for Treatment of Constipation

Recent solubility and dissolution enhancement techniques for repaglinide a BCS class II drug: a review

Contact Info

Product

Resources

About