Introduction: Medication disposal is an alarming issue today and gaining more and more awareness from the healthcare professionals as well as consumers. Pharmacists have the potential to be on the forefront of this movement as a healthcare professionals and pharmacists are in an admirable position to educate patients about safe drug disposal. Proper patient counselling on safe medication disposal can make a significant difference to public health and the environment. The knowledge on method of disposal of unused medicines is equally important as that of consumption of medicines. Objective: This article aims to provide a background, the importance and significance of proper medication disposal, describe the correct methods to dispose of unwanted and expired medications. Method: The information about methods of proper disposal as well as consequence of improper disposal was collected by extensive literature survey of all available resources. Conclusion: Till date, researchers have acknowledged many human and veterinary pharmaceutical compounds at serious concentrations in drinking water resources and they are a major contributor to environmental pollution. Emphasis is also given on pharmacist role in proper disposal of unwanted and expired medicine makes a significant impact on the environment as well as it prevents accident, poisoning and intentional violence. So it will lead to the welfare of society and trudge towards goal of 2020 health for all.
Objective: The purpose of current study was to improve physicochemical properties such as micrometric, compressibility and solubility of linezolid (LNZ) by preparing crystallo-co-agglomerates (CCA) in the presence of polymer for the enhancement of overall physicochemical performance.
Methods:The process of agglomeration involves the use of dichloromethane (DCM) as a good solvent and chloroform as bridging liquid were used to prepare agglomerates. Agglomerates were characterised in the solid state using several techniques such as Scanning electronic microscopy(SEM), Fourier transformation infrared spectroscopy (FTIR), X-ray powder diffraction analysis (XRPD) The agglomerates obtained were evaluated for micrometric, mechanical, deformation, compressibility and drug release properties.Results: It was found that micrometric properties and dissolution characteristics of agglomerates were significantly improved than that of pure linezolid. Solubility was found to be increased than pure linezolid. The solubility of crystallo co-agglomerates was found an increase in 5 fold 3 fold and 3.7 fold for PVPK30 (0.5%), PVPK30 (0.25%) and PVPK30 (0.75%) respectively. The angle of repose for all batches was found between 22 ° to 30 °Carrs index was between 12.27±0.6 to 18.73±0.4 and Hausners ratio Near to 1, indicated good flow ability of agglomerates. The time required for drug release over a period of 60 min, is as LA1>LA2>LA3. LA3 shows fast drug release than LA1 and LA2, due to solubilization of drug due to more concentration of PVPK30 and less concentration of talc.Conclusion: Based on the above results, it was revealed that CCA of linezolid prepared with DCM and HPMC (Hydroxypropyl methyl cellulose)/PEG (Polyethylene glycol)/PVP (Polyvinylpyrrolidone) K30 exhibited improved micrometric properties, compressibility and in addition to improving solubility and dissolution rate.
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