Introduction: Diabetes mellitus, a metabolic disorder characterized by increased blood sugar level. Metformin hydrochloride is used to treat type I Diabetes mellitus. Metformin hydrochloride chemically 1, 1-dimethylbiguanide hydrochloride, is white crystalline powder, hygroscopic and freely soluble in water, Officially UV spectrophotometric method used for estimation of Metformin Hydrochloride from the bulk and tablets formulations. Objective: Develop and validate a simple, rapid, accurate, economic and precise UV/VIS method for Metformin Hydrochloride in bulk and tablets formulation. Methodology: Choices of a common solvent were essential so various solvent ranges including methanol, ethanol, acetonitrile and phosphate buffer and various concentrations ranges of various buffers were analyzed. Conclusion: Among different solvents water has showed better results, hence water was selected as a solvent for the proposed method. Metformin Hydrochloride showed maximum absorbance at 234 nm. The percentage recoveries for Metformin Hydrochloride were found in the range of 99-101 %. Method was quantitatively evaluated in terms of linearity, accuracy, precision, ruggedness, robustness and recovery. The method was simple, convenient and suitable for the determination of Metformin Hydrochloride from bulk and tablet dosage forms.
Objectives:The Main objective of this study was to develop and optimize Capecitabine loaded nanoliposomes for prolonged drug delivery in cancer treatment. Methods: Liposomes were prepared by the thin film hydration method followed by sonication. The parameters affecting the vesicle size and percentage drug entrapment of liposome are amount of soyaphosphatidyl choline and cholesterol used in their preparation. The Capecitabine liposomal formulation was optimized using 3 2 factorial design in this amount of soya Phosphatidylcholine and cholesterol were selected as two independent variables to obtain stable liposome with small vesicle size and maximum entrapment efficiency. Results: Compatibility studies were carried out by using FT-IR and DSC, the results showed that there was no significant interaction between drug and excipients. The formulated liposomal prepartions were evaluated for various parameters and results were obtained for optimized batch (B3) Showed vesicle size 178.9nm, zeta potential -77.9mV to -82.7mV, entrapment efficiency 79.65% and percentage drug release 92.07% up to 12 h. Conclusion: Liposomal drug delivery is targeted as to provide more drug concentration at the site of action and with a sustainable drug release followed Higuchi-matrix model. Ultimately, reducing the dosing frequency with minimizing the side effects related to high drug intake. Liposome has been provided a spectrum of options and opportunities for designing and practicing site specific, targeted drug therapy.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.