Polydopamine surface-modified nanocarriers for improved anticancer activity: Current progress and future prospects

Honmane, Sandip M.; Charde, Manoj S.; Salunkhe, Sachin S.; Choudhari, Prafulla B.; Nangare, Sopan

doi:10.1016/j.onano.2022.100059

Cited by 20 publications

(12 citation statements)

References 130 publications

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“…In this context, nanocarrier-based targeted anticancer drug delivery systems with minimal off-target effects on healthy cells are known to be promising for chemotherapy. A nanocarriers-derived delivery system has various benefits, including better intracellular penetration, control over the pharmacokinetics, tissue distribution profile of the drug, and protection from degradation and premature interaction with the biological environment. , However, in order to be effective, a nanocarrier must be made from a biocompatible material, readily functionalizable, with high intracellular absorption efficiency in cancer cells, and also have a long circulation half-life …”

Section: Introductionmentioning

confidence: 99%

“…5,6 However, in order to be effective, a nanocarrier must be made from a biocompatible material, readily functionalizable, with high intracellular absorption efficiency in cancer cells, and also have a long circulation half-life. 7 In the literature, numerous types of nanomaterials-based drug carriers with small size and high surface area have been extensively explored for cancer therapy. 8,9 These materials can be categorized mainly into organic and inorganic nanocarriers.…”

Section: Introductionmentioning

confidence: 99%

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Review of Carbon Dot-Based Drug Conjugates for Cancer Therapy

Dubey

Dhiman

Koner

2023

ACS Appl. Nano Mater.

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Carbon Dots (CDs) are a class of carbon-based nanostructure known as zero-dimensional nanomaterial and have great potential in the field of targeted chemotherapy. CDs have been extensively explored for bioimaging, sensing, and therapy due to their high quantum yield, low cytotoxicity, high water solubility, good photostability, and tunable excitation wavelength-dependent emission properties. CDs conjugated with various anticancer drugs such as Doxorubicin (DOX), Epirubicin and Temozolomide, Protoporphyrin IX (PpIX), 5-Fluorouracil, Curcumin, Gemcitabine, Methotrexate (MTX), Oxaliplatin, and Cisplatin are explored for chemotherapy applications. These drugs are conjugated with CDs via covalent bond formation such as amide, ester, and hydrazine or with the help of noncovalent electrostatic attraction from opposite charges and hydrogen-bonding interactions. The release of these drug molecules can be controlled with the help of the acidic pH or via highly reactive and abundant small molecular species present in a cancerous environment compared to normal physiological conditions. The CDs-drug conjugate can be specifically released in a targeted manner with the help of a specific substrate attached at the surface and their interaction with overexpressed cell surface receptors. In this review, we demonstrate the application of CDs-drug conjugate toward drug delivery systems for oncology applications.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Review of Carbon Dot-Based Drug Conjugates for Cancer Therapy

Dubey

Dhiman

Koner

2023

ACS Appl. Nano Mater.

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“…Surface modification of nanocarriers is done by various approaches such as using polymers, ligands, surfactants, and fatty acids . Surface-modified nanocarriers enhanced penetration efficiency, controlled release, and targeted medication delivery . The different types of surface modifiers are represented in Figure .…”

Section: Introductionmentioning

confidence: 99%

“… 12 Surface-modified nanocarriers enhanced penetration efficiency, controlled release, and targeted medication delivery. 13 The different types of surface modifiers are represented in Figure 1 .…”

Section: Introductionmentioning

confidence: 99%

Surface Modification of Lipid-Based Nanocarriers: A Potential Approach to Enhance Targeted Drug Delivery

2022

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Nanocarriers have the utmost significance for advancements in drug delivery and nanomedicine technology. They are classified as polymer-based nanocarriers, lipid-based nanocarriers, viral nanoparticles, or inorganic nanoparticles, depending on their constituent parts. Lipid-based nanocarrier systems have gained tremendous attention over the years because of their noteworthy properties like high drug-loading capacity, lower toxicity, better bioavailability and biocompatibility, stability in the gastrointestinal tract, controlled release, simpler scale-up, and validation process. Nanocarriers still have some disadvantages like poor drug penetration, limited drug encapsulation, and poor targeting. These disadvantages can be overcome by their surface modification. Surface-modified nanocarriers result in controlled release, enhanced penetration efficiency, and targeted medication delivery. In this review, the authors summarize the numerous lipidbased nanocarriers and their functionalization through various surface modifiers such as polymers, ligands, surfactants, and fatty acids. Recent examples of newly developing surface-modified lipid-based nanocarrier systems from the available literature, along with their applications, have been compiled in this work.

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“…Since the pros of PDA outweigh its cons, various groups of scientists have modified the biomaterials’ surfaces by employing PDA with the aim of augmenting their surface performance. Therefore, within the last couple of years, PDA has been in the spotlight, with diverse applications in the field of biomedical engineering ( Lynge et al, 2011 ), including drug delivery ( Huang et al, 2018 ), implants ( Jia et al, 2019 ), surface engineering ( Yang et al, 2015 ), cancer therapy ( Abdollahi et al, 2022 ; Honmane et al, 2022 ), TE (bone ( Huang et al, 2016 ; Kaushik et al, 2020 ), cartilage ( Huang et al, 2021 ), muscle ( Zhou et al, 2021 ), skin ( Yazdi et al, 2022 ), tendon ( Lin et al, 2019 ), and neuron ( Qian et al, 2018 ; Yan et al, 2020 )), and microfluidic systems ( Niculescu et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

The effects of process parameters on polydopamine coatings employed in tissue engineering applications

Sarkari

Khajehmohammadi

Davari

et al. 2022

Front. Bioeng. Biotechnol.

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The biomaterials’ success within the tissue engineering field is hinged on the capability to regulate tissue and cell responses, comprising cellular adhesion, as well as repair and immune processes’ induction. In an attempt to enhance and fulfill these biomaterials’ functions, scholars have been inspired by nature; in this regard, surface modification via coating the biomaterials with polydopamine is one of the most successful inspirations endowing the biomaterials with surface adhesive properties. By employing this approach, favorable results have been achieved in various tissue engineering-related experiments, a significant one of which is the more rapid cellular growth observed on the polydopamine-coated substrates compared to the untreated ones; nonetheless, some considerations regarding polydopamine-coated surfaces should be taken into account to control the ultimate outcomes. In this mini-review, the importance of coatings in the tissue engineering field, the different types of surfaces requiring coatings, the significance of polydopamine coatings, critical factors affecting the result of the coating procedure, and recent investigations concerning applications of polydopamine-coated biomaterials in tissue engineering are thoroughly discussed.

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Polydopamine surface-modified nanocarriers for improved anticancer activity: Current progress and future prospects

Cited by 20 publications

References 130 publications

Review of Carbon Dot-Based Drug Conjugates for Cancer Therapy

Review of Carbon Dot-Based Drug Conjugates for Cancer Therapy

Surface Modification of Lipid-Based Nanocarriers: A Potential Approach to Enhance Targeted Drug Delivery

The effects of process parameters on polydopamine coatings employed in tissue engineering applications

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