The effects of process parameters on polydopamine coatings employed in tissue engineering applications

Sarkari, Soulmaz; Khajehmohammadi, Mehran; Davari, Niyousha; Li, Dejian; Yu, Baoqing

doi:10.3389/fbioe.2022.1005413

Cited by 17 publications

(9 citation statements)

References 111 publications

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“…Hydrophilicity is a critical property of scaffolds because it affects cells initial attachment, diffusion, and proliferation 57,58 . Water contact angle (WCA) which represents the materials wetting ability was used to compare uncoated scaffolds with gelatin‐coated ones to determine the influence of gelatin coating on the hydrophilicity (or wettability) of printed PCL scaffolds.…”

Section: Methodsmentioning

confidence: 99%

“…Hydrophilicity is a critical property of scaffolds because it affects cells initial attachment, diffusion, and proliferation. 57,58 Water contact angle (WCA) which represents the materials wetting ability was used to compare uncoated scaffolds with gelatin-coated ones to determine the influence of gelatin coating on the hydrophilicity (or wettability) of printed PCL scaffolds. The contact angle between the scaffold surface as a solid phase and water was determined according to the sessile drop technique using a video contact angle analyzer (VCA Optima, AST Products, Inc., MA, USA).…”

Section: Water Contact Angle Measurementmentioning

confidence: 99%

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Effect of porosity on mechanical and biological properties of bioprinted scaffolds

Khajehmohammadi

Tafti

Nikukar

2022

J Biomedical Materials Res

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Treatment of tissue defects commonly represents a major problem in clinics due to difficulties involving a shortage of donors, inappropriate sizes, abnormal shapes, and immunological rejection. While many scaffold parameters such as pore shape, porosity percentage, and pore connectivity could be adjusted to achieve desired mechanical and biological properties. These parameters are crucial scaffold parameters that can be accurately produced by 3D bioprinting technology based on the damaged tissue. In the present research, the effect of porosity percentage (40%, 50%, and 60%) and different pore shapes (square, star, and gyroid) on the mechanical (e.g., stiffness, compressive and tensile behavior) and biological (e.g., biodegradation, and cell viability) properties of porous polycaprolactone (PCL) scaffolds coated with gelatin have been investigated. Moreover, human foreskin fibroblast cells were cultured on the scaffolds in the in-vitro procedures. MTT assay (4, 7, and 14 days) was utilized to determine the cytotoxicity of the porous scaffolds. It is revealed that the porous scaffolds produced by the bioprinter did not produce a cytotoxic effect. Among all the porous scaffolds, scaffolds with a pore size of about 500 μm and porosity of 50% showed the best cell proliferation compared to the controls after 14 days. The results demonstrated that the pore shape, porosity percentage, and pore connectivity have an important role in improving the mechanical and biological properties of porous scaffolds. These 3D bioprinted biodegradable scaffolds exhibit potential for future application as polymeric scaffolds in hard tissue engineering applications.

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Section: Methodsmentioning

confidence: 99%

Section: Water Contact Angle Measurementmentioning

confidence: 99%

Effect of porosity on mechanical and biological properties of bioprinted scaffolds

Khajehmohammadi

Tafti

Nikukar

2022

J Biomedical Materials Res

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“…The selection of the type of hydrogel for the cartilage repair should satisfy several criteria, including swelling ability, porosity-related parameters, permeability, biocompatibility, biodegradability, cell functionality, and required mechanical needs. [91][92][93][94][95] Of note, the compressive strength of hydrogels is an essential characteristic for scaffolds employed in the cartilage TE to support external forces. [96] Furthermore, it is widely acknowledged that the matrix stiffness has a significant impact on the differentiation of cells into chondrocytes.…”

Section: Traditional Hydrogelsmentioning

confidence: 99%

Progress of Microfluidic Hydrogel‐Based Scaffolds and Organ‐on‐Chips for the Cartilage Tissue Engineering

et al. 2023

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Cartilage degeneration is among the fundamental reasons behind disability and pain across the globe. Numerous approaches have been employed to treat cartilage diseases. Nevertheless, none have shown acceptable outcomes in the long run. In this regard, the convergence of tissue engineering and microfabrication principles can allow developing more advanced microfluidic technologies, thus offering attractive alternatives to current treatments and traditional constructs used in tissue engineering applications. Herein, the current developments involving microfluidic hydrogel‐based scaffolds, promising structures for cartilage regeneration, ranging from hydrogels with microfluidic channels to hydrogels prepared by the microfluidic devices, that enable therapeutic delivery of cells, drugs, and growth factors, as well as cartilage‐related organ‐on‐chips are reviewed. Thereafter, cartilage anatomy and types of damages, and present treatment options are briefly overviewed. Various hydrogels are introduced, and the advantages of microfluidic hydrogel‐based scaffolds over traditional hydrogels are thoroughly discussed. Furthermore, available technologies for fabricating microfluidic hydrogel‐based scaffolds and microfluidic chips are presented. The preclinical and clinical applications of microfluidic hydrogel‐based scaffolds in cartilage regeneration and the development of cartilage‐related microfluidic chips over time are further explained. The current developments, recent key challenges, and attractive prospects that should be considered so as to develop microfluidic systems in cartilage repair are highlighted.

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“…Hence has been widely used in regulating tissue and cellular response to materials (Shokrollahi et al, 2020;Ghorbani et al, 2021). PDA's adhesive intensity is attributed to its catechol and aminoethyl groups (Gao et al, 2019;Sarkari et al, 2022). A reduction in aminoethyl groups through extensive 5,6-dihydroxyindole (DHI) synthesis reduces adhesiveness.…”

Section: Introductionmentioning

confidence: 99%

A critical review on polydopamine surface-modified scaffolds in musculoskeletal regeneration

Tolabi

Bakhtiary

Sayadi

et al. 2022

Front. Bioeng. Biotechnol.

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Increasing concern about age-related diseases, particularly musculoskeletal injuries and orthopedic conditions, highlights the need for strategies such as tissue engineering to address them. Surface modification has been developed to create pro-healing interfaces, personalize scaffolds and provide novel medicines. Polydopamine, a mussel-inspired adhesive polymer with highly reactive functional groups that adhere to nearly all substrates, has gained attention in surface modification strategies for biomaterials. Polydopamine was primarily developed to modify surfaces, but its effectiveness has opened up promising approaches for further applications in bioengineering as carriers and nanoparticles. This review focuses on the recent discoveries of the role of polydopamine as a surface coating material, with focus on the properties that make it suitable for tackling musculoskeletal disorders. We report the evolution of using it in research, and discuss papers involving the progress of this field. The current research on the role of polydopamine in bone, cartilage, muscle, nerve, and tendon regeneration is discussed, thus giving comprehensive overview about the function of polydopamine both in-vitro and in-vivo. Finally, the report concludes presenting the critical challenges that must be addressed for the clinical translation of this biomaterial while exploring future perspectives and research opportunities in this area.

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The effects of process parameters on polydopamine coatings employed in tissue engineering applications

Cited by 17 publications

References 111 publications

Effect of porosity on mechanical and biological properties of bioprinted scaffolds

Effect of porosity on mechanical and biological properties of bioprinted scaffolds

Progress of Microfluidic Hydrogel‐Based Scaffolds and Organ‐on‐Chips for the Cartilage Tissue Engineering

A critical review on polydopamine surface-modified scaffolds in musculoskeletal regeneration

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