First report about the mode of action of combined butafosfan and cyanocobalamin on hepatic metabolism in nonketotic early lactating cows

Kreipe, L.; Denız, A.; Bruckmaier, Rupert M.; Dorland, H.A. van

doi:10.3168/jds.2010-4080

Cited by 21 publications

(46 citation statements)

References 17 publications

(25 reference statements)

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“…The former is responsible for 50% of the osmotic pressure, partially determining the milk volume (Boutinaud et al, 2008). Besides, this was not the central hypothesis of this study, other authors have already demonstrated an increase in the production of dairy cows supplemented with 5 doses of 1000mg butaphosphan and 0.5mg cyanocobalamin (Pereira et al, 2013), or 3 doses of 10mg butaphosphan and 0.05mg cyanocobalamin/kg body weight (Kreipe et al, 2011).…”

Section: Discussionmentioning

confidence: 76%

“…Furthermore, this association decreases the expression of hepatic enzyme, which act on the metabolism of fatty acids, and increases the expression of the β-oxidation enzyme route (Kreipe et al, 2011). Therefore, the hypothesis of this study is that combined use of butaphosphan and cyanocobalamin could enhance peripheral insulin resistance, increase the amount of glucose available for the mammary gland and increase milk production.…”

Section: Introductionmentioning

confidence: 99%

“…The combined use of butaphosphan, organic source of phosphorus, and cyanocobalamin, which contributes to the gluconeogenesis (Kreipe et al, 2011) has proven to have an effect on milk production and the NEB of cows (Pereira et al, 2013). Furthermore, this association decreases the expression of hepatic enzyme, which act on the metabolism of fatty acids, and increases the expression of the β-oxidation enzyme route (Kreipe et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Combinação de butafosfan e cianocobalamina no metabolismo da glicose em vacas leiteiras após o parto

Tabeleão

Schwegler

Pereira

et al. 2017

Arq. Bras. Med. Vet. Zootec.

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Combinação de butafosfan e cianocobalamina no metabolismo da glicose em vacas leiteiras após o parto ABSTRACTThe hypothesis of this study is that the combined use of butaphosphan and cyanocobalamin could enhance peripheral insulin resistance, increasing the amount of glucose available for the mammary gland and milk production. Thus, our aim was to investigate the combined effects of butaphosphan and cyanocobalamin on the glucose metabolism in dairy cows during the postpartum period. Twenty one dairy cows were divided into two groups: Control Group (CON, n= 11), that received 5 injections of saline solution (20mL/animal 0.9 % NaCl), and Catosal group (ABC, n= 10) which received 5 injections of 20mL of a Butafosfan and Cyanocobalamin solution (Catosal ® B 12 , 100mg of Butafosfan and 50µg Cyanocobalamin for mL). The injections were performed by intramuscular route, on days 7, 12, 17, 22 and 27 postpartum. Blood samples were taken on these days to evaluate plasma concentrations of phosphorus, glucose, non-esterified fatty acids (NEFA), albumin, aspartate aminotransferase (AST) and creatine kinase (CK). On days 8 and 28 postpartum, the animals were weighted and subjected to the glucose tolerance and insulin challenge tests. The treatment promoted weight loss (ABC 40.4kg, CON 10.73kg, P< 0.05) and increased AST (ABC 62.92 ±3.31U/L, CON 53.11 ±3.49U/L, P< 0.05) and CK levels (ABC 134.09 ±19.08U/L, CON 79.43 ±18.27U/L). Glucose metabolism (area under the curve) did not differ (P> 0.05) among groups on days 8 and 28; however, ABC animals showed higher serum glucose levels (P< 0.05) after insulin administration on day 28 postpartum (97.54 ±8.54mg/dL) when compared to day 8 (83.01 ±8.54mg/dL). It could be concluded that the combined use of butaphosphan and cyanocobalamin interferes positively with the adaptation of glucose metabolism in dairy cows in early lactation.Keywords: energetic metabolism, organic phosphorus, insulin resistance, dairy cows (CON, n= 11 (ABC 40,4kg, CON 10,73kg, P<0,05) e aumento da AST (ABC 62,92 ±3,31U/L, CON 53,11±3,49 U / L, P<0,05) RESUMO A hipótese deste estudo é de que o uso da combinação de butafosfan e cianocobalamina pode melhorar a resistência periférica à insulina, aumentar a quantidade de glicose disponível para a glândula mamária e a produção de leite. Assim, o objetivo foi investigar os efeitos combinados de butafosfan e cianocobalamina sobre o metabolismo da glicose em vacas leiteiras no período pós-parto. Vinte e uma vacas leiteiras foram divididas em dois grupos: grupo controle

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Section: Discussionmentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Combinação de butafosfan e cianocobalamina no metabolismo da glicose em vacas leiteiras após o parto

Tabeleão

Schwegler

Pereira

et al. 2017

Arq. Bras. Med. Vet. Zootec.

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“…Butafosfan, a compound of organic phosphorus, is not only used as a phosphorus source for animals but also plays a vital role in hepatic carbohydrate metabolism (Kreipe et al, 2011). In addition, butafosfan has been regarded as an antistress agent in combination with vitamin B12.…”

mentioning

confidence: 99%

“…In addition, butafosfan has been regarded as an antistress agent in combination with vitamin B12. (Kreipe et al, 2011;Grace et al, 2014). Studies with butafosfan in different animals have shown that it improved general health status by stimulating feed intake, immune system, and digestive function (Kreipe et al, 2011).…”

mentioning

confidence: 99%

Pharmacokinetics of butafosfan after intravenous and intramuscular administration in piglets

Sun

Wang

Yang

et al. 2016

Vet Pharm & Therapeutics

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The pharmacokinetics and bioavailability of butafosfan in piglets were investigated following intravenous and intramuscular administration at a single dose of 10 mg/kg body weight. Plasma concentration-time data and relevant parameters were best described by noncompartmental analysis after intravenous and intramuscular injection. The data were analyzed through WinNolin 6.3 software. After intravenous administration, the mean pharmacokinetic parameters were determined as T of 3.30 h, Cl of 0.16 L kg/h, AUC of 64.49 ± 15.07 μg h/mL, V of 0.81 ± 0.44/kg, and MRT of 1.51 ± 0.27 h. Following intramuscular administration, the C (28.11 μg/mL) was achieved at T (0.31 h) with an absolute availability of 74.69%. Other major parameters including AUC and MRT were 48.29 ± 21.67 μg h/mL and 1.74 ± 0.29 h, respectively.

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Effects of intravenous butaphosphan and cyanocobalamin to late pregnant ewes on the metabolic indices around parturition and weight gain of their lambs after birth

Barimanloo

Chalmeh

Pourjafar

et al. 2021

Veterinary Medicine & Sci

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Background: Management and control of metabolic disorders in sheep around parturition is important. and various researchers have suggested different managerial solutions. Butaphosphan and cyanocobalamin are widely used for curing metabolic disorders resulting from poor nutrition, inadequate management or diseases.Objectives: It was hypothesised that butaphosphan and cyanocobalamin could improve the metabolism of ewes around parturition.Methods: Twenty-eight clinically healthy 3-year-old pregnant Afshari ewes from 21 days before parturition were enrolled into four equal groups: control (Ctrl), B+C1, B+C2 and B+C3. The Ctrl group only received intravenous normal saline and B+C1, B+C2 and B+C3 ewes, respectively, received an intravenous combination of 10% butaphosphan and 0.005% cyanocobalamin at 2, 4 and 6 ml/ewe, on Days 19-21, 10-12 and 1-3 before parturition. Blood samples were taken from all the ewes on Days 21, 12 and 3 before lambing at parturition day and on days 3, 12 and 21 after parturition.A body condition score of all the ewes was assessed at blood sampling days, and lambs born from the ewes were weighed at birth and every 2 weeks up to 3 months. Serum concentrations of glucose, cortisol, non-esterified fatty acids, beta-hydroxy butyric acid, triglyceride, cholesterol, high-, low-and very-low-density lipoproteins, aspartate aminotransferase and alanine aminotransferase were measured.Results: This drug combination decreased circulating glucose, cortisol, lipid profile and hepatic enzymes via dose-dependent manner, 6 ml of this drug compound/ewe was more potent than 4 and 2 ml/ewe. The lambs' weight from mothers receiving 6 ml of this combination was significantly higher than those of the others. Conclusions:It may be suggested that the intravenous administration of 6 ml/ewe of this combination for 3 consecutive days in three states before parturition had prophylactic effects on metabolic disorders of ewes and enhanced the lambs weight gain after birth.

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First report about the mode of action of combined butafosfan and cyanocobalamin on hepatic metabolism in nonketotic early lactating cows

Cited by 21 publications

References 17 publications

Combinação de butafosfan e cianocobalamina no metabolismo da glicose em vacas leiteiras após o parto

Combinação de butafosfan e cianocobalamina no metabolismo da glicose em vacas leiteiras após o parto

Pharmacokinetics of butafosfan after intravenous and intramuscular administration in piglets

Effects of intravenous butaphosphan and cyanocobalamin to late pregnant ewes on the metabolic indices around parturition and weight gain of their lambs after birth

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