Fenvalerate-induced oxidative damage in rat tissues and its attenuation by dietary sesame oil

Prasanthi, K.; Muralidhara, .; Rajini, P.S.

doi:10.1016/j.fct.2004.10.005

Cited by 103 publications

(56 citation statements)

References 35 publications

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“…Also, an important function of GST in response to oxidative stress is its ability to conjugate GSH with lipid peroxidation products [36]. Previous studies demonstrated that pyrethroids exposure altered antioxidant defense mechanisms and enhanced lipid peroxidation in rat liver [14,[37][38][39], erythrocytes [37] and in fish [40]. Exposure of rats to a single dose of the pyrethroids, cypermethrin (25 μg kg −1 ) and fenvalerate (4.5 μg kg -1 ), lowered the activities of the antioxidant enzymes SOD and CAT, resulting in both lipid peroxidation and decreased levels of GSH in erythrocytes [41].…”

Section: Discussionmentioning

confidence: 99%

Impact of Oxidative Stress and Lipid Peroxidation Induced by Lambdacyhalothrin on P450 in Male Rats: The Ameliorating Effect of Zinc

Abbassy¹,

Marzouk²,

Mansour³

et al. 2014

J Environ Anal Toxicol

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Section: Discussionmentioning

confidence: 99%

Impact of Oxidative Stress and Lipid Peroxidation Induced by Lambdacyhalothrin on P450 in Male Rats: The Ameliorating Effect of Zinc

Abbassy¹,

Marzouk²,

Mansour³

et al. 2014

J Environ Anal Toxicol

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“…12,13 Few reports have demonstrated the induction of oxidative stress by pyrethroids. [12][13][14][15] CYP is an insecticide that belongs to the family of synthetic pyrethroids. Its chemical formula is alpha-cyano-3-phenoxybenzyl ester of 2,2 dimethyl-3-(2,2 dichlorovinyl)-cyclopropane carboxilic acid,, the most widely used type II pyrethroid pesticides.…”

Section: Introductionmentioning

confidence: 99%

Dose-Dependent Hematological, Hepatic and Gonadal Toxicity of Cypermethrin in Wistar Rats

Das¹,

Ghosh²,

Paramanik³

et al. 2017

Toxicol Forensic Med Open J

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CitationPesticides are used frequently and may have various adverse effects on human health in different ways. Cypermethrin (CYP) is a synthetic type II pyrethroid pesticide that has been used extensively to control a wide variety of pests in agriculture, forestry, horticulture, and public health. Objectives: This study aimed to investigate the dose-dependent hematological, hepatic and gonadal toxicity of CYP in mature male and female Wistar rats. Methods: Rats were randomly divided into nine groups, different doses of CYP were administered for 14 consecutive days and different hematological, hepatic and gonadal parameters were assayed. Results: Erythrocyte count, hemoglobin percentage, hepatic reduced glutathione (GSH) content and sperm count were significantly diminished. Serum aspartic and alanine transaminase, hepatic malondialdehyde (MDA), testicular cholesterol content were increased following CYP treatment in male rats at 40 and 80 mg/kg body weight (1/9 and 1/4.5 LD 50 ). Elevated ovarian cholesterol content and decreased 17β hydroxy steroid dehydrogenase (HSD) levels were also observed in CYP-exposed female rats at a dose level of 34.33 and 51.5 mg/kg body wt. (1/9 and 1/6 LD 50 ). Conclusion: Taken together, CYP initiated hematological, hepatic and gonadal toxicity in mature male rats with a body weight of 40 mg/kg (1/9 LD 50 ) and gonadal toxicity in mature female rats with a body weight of 34.33 mg/kg (1/9 LD 50 ) and above.

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“…Pati and Bhunya (1989) reported that fenvalerate significantly increased chromosomal aberrations (CA) and MN formation in mice. In a study conducted by Prasanthi et al (2005), it was determined that fenvalerate caused oxidative damage in male rats.…”

Section: Introductionmentioning

confidence: 99%

Mutagenic biomonitoring of pirethroid insecticides in human lymphocyte cultures: Use of micronuclei as biomarkers and recovery byRosa caninaextracts of mutagenic effects

Kasimoğlu

Uysal

2014

Pharmaceutical Biology

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Context: Insecticides are used to control pests. Cypermethrin and fenvalerate are widely used pirethroid insecticides in the world. Rosa canina L. (Rosaceae) is used as a traditional medicinal plant against viral infections and disorders of the kidneys and urinary tract due to its high vitamin C level. Objective: The genotoxic effects of cypermethrin and fenvalerate were examined with the micronucleus (MN) test. Then, we determined the ability of the water (RC wtr ) and ethanol (RC eta ) extracts of rosehip (R. canina) to overcome the possible genotoxic effects of the insecticides. Materials and methods: Preliminary studies determined that the application concentrations were 20, 30, 40, and 50 ppm for cypermethrin, 25, 50, 75, and 100 ppm for fenvalerate, and 100 ppm for rosehip extracts. DMSO (dimethyl sulphoxide) (1%) and 1 mM EMS (ethyl methanesulfonate) were used as negative and positive control groups, respectively. The application groups belonging to insecticides and plant extracts were added to culture tubes including chromosome B medium and peripheral blood for MN test. Results: The MN frequencies were found 0.725 in the negative control group, 2.700 in the positive control groups, 1.275 in the highest application group of cypermethrin, and 1.600 in the highest application group of fenvalerate. The MN frequencies in cypermethrin + RC wtr , cypermethrin + RC eta , fenvalerate + RC wtr , and fenvalerate + RC eta application groups were, respectively, determined as 1.000, 1.075, 1.225, and 1.275. Conclusion: According to the results, cypermethrin and fenvalerate have genotoxic effects, the water and ethanol extracts of rosehip reduced the genotoxicity of the both insecticides.

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Fenvalerate-induced oxidative damage in rat tissues and its attenuation by dietary sesame oil

Cited by 103 publications

References 35 publications

Impact of Oxidative Stress and Lipid Peroxidation Induced by Lambdacyhalothrin on P450 in Male Rats: The Ameliorating Effect of Zinc

Impact of Oxidative Stress and Lipid Peroxidation Induced by Lambdacyhalothrin on P450 in Male Rats: The Ameliorating Effect of Zinc

Dose-Dependent Hematological, Hepatic and Gonadal Toxicity of Cypermethrin in Wistar Rats

Mutagenic biomonitoring of pirethroid insecticides in human lymphocyte cultures: Use of micronuclei as biomarkers and recovery byRosa caninaextracts of mutagenic effects

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