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Lead metal is highly inert metal used widely because of its mechanical properties like high density, low melting point and ductility. Half of the lead produced is used as electrodes in lead acid car batteries, construction of buildings and pipes. Lead is poisonous to human beings if inhaled or swallowed. Achyranthus aspera and Phyllanthus amarus both the plants are widely available as weeds and they have excellent medicinal values. These plants are extensively used in folk, Ayurveda and Unani medicines. The leaves, stems, fruits, flowers and seeds cut from both the plants were washed with distilled water and dried in sun light. The dried materials were crushed and meshed to reduce the size of the particles below75μ and activated at 100 0 C using hot air oven. At pH 6, at the period of 7 days with maximum adsorbent dose seed ash and dry powders of P.amarus plant shown highest adsorption of lead 88.54% and 86.75% respectively. At the same conditions A.aspera's flowers ash and dry powders has shown 84.69% and 80.61% of lead adsorption from polluted water. The Bio sorbent powders are structurally analyzed with FT-IR spectroscopy before and after adsorption.

Dapiprazole hydrochloride is an α-adrenergic blocking agent 1,2. Chemically, it is 5,6,7,8-tetrahydro-3-[2-(4-o-tolyl-1-piperazinyl)ethyl]-s-triazolo[4,3-a] pyridine hydrochloride 3 (empirical formula C19H27N5•HCl, m.w. 361.93). It is a sterile, white, lyophilized powder soluble in water. Dapiprazole hydrochloride ophthalmic solution is indicated in the treatment of iatrogenically induced mydriasis produced by adrenergic (phenylephrine) or parasympatholytic (tropicamide) agents 4. The aim of this paper was to develop validate a simple and reliable HPLC-UV method for the simultaneous determination of dapiprazole and its process related impurity-A. Besides the simple route of synthesis for dapiprazole, we have observed a potential impurity (Imp-A) in our synthetic process and some unknown impurities in forced degradation. Hence, a stabilityindicating HPLC method for determination of dapiprazole in presence of process and degradation impurities was developed and validated as per International Conference on Harmonization (ICH) guidelines. This manuscript describes the development and validation, in accordance with ICH guidelines, of a rapid, economical, precise and accurate stability-indicating isocratic reversed-phase HPLC method for analysis of dapiprazole in the presence of its process related impurity. This paper also deals with the forced degradation of dapiprazole under the stress conditions acidic and basic hydrolysis, oxidation, heat and light and validation of the method for accurate quantification

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