Impact of Oxidative Stress and Lipid Peroxidation Induced by Lambdacyhalothrin on P450 in Male Rats: The Ameliorating Effect of Zinc

Abbassy, Moustafa A.; Marzouk, Mamdouh A; Mansour, Sameeh A.; Shaldam, Hassan A; Mossa, Abdel‐Tawab H.

doi:10.4172/2161-0525.1000218

Cited by 12 publications

(9 citation statements)

References 41 publications

(49 reference statements)

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“…In agreement with the current results, Abbassy et al [12] revealed that pesticides caused a statistical significant decrease in SOD activity and elevation in MDA levels in rats, and Zn supplementation normalized the levels of SOD. They attributed their results to the importance of Zn as an essential component of SOD.…”

Section: Discussionsupporting

confidence: 93%

“…Highly reactive oxygen metabolites formed during pesticides' exposure act on the unsaturated fatty acids of phospholipid components of cell membrane to produce MDA. All these effects were inhibited by Zn supplementation [12]. Previous studies have reported that male rats that were chronically intoxicated with pesticides showed a decreased concentration of Zn in both liver and serum [13].…”

Section: Introductionmentioning

confidence: 90%

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Effects of zinc supplementation on oxidant/antioxidant and lipids status of pesticides sprayers

Saad-Hussein

Ibrahim

Abdalla

et al. 2019

Journal of Complementary and Integrative Medicine

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AbstractBackgroundExcess exposure to pesticides induces oxidative stress and causes alteration in the lipid profileObjectivesThe study aimed to evaluate the effects of Zinc (Zn) supplementation on the oxidant/antioxidant and lipid status in pesticide sprayers.MethodsForty pesticide sprayers were included in the study. Blood lipids, malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD), and Zn were estimated; before and after Zn supplementation.ResultsStatistical analysis revealed that after Zn supplementation, total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL), and MDA were significantly decreased. However, there was a significant increase in the high density lipoprotein (HDL), SOD, GPx, and Zn levels. After Zn supplementation, significant inverse correlations were detected between the Zn and the levels of MDA, TG, and VLDL, while positive correlation between Zn and the levels of HDL and TC.ConclusionsZn supplementation improves the oxidative/antioxidants and lipid status in pesticide sprayers.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 90%

Effects of zinc supplementation on oxidant/antioxidant and lipids status of pesticides sprayers

Saad-Hussein

Ibrahim

Abdalla

et al. 2019

Journal of Complementary and Integrative Medicine

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“…Previous studies indicate that insecticides in both in vivo and in vitro test (Mossa et al, 2012;, alter the enzyme activities associated with antioxidant defense mechanisms. The result of this study corroborates the findings of Abbassy et al (2014), who reported a significant decrease in SOD, GPx and CAT activity and an increase in MDA level of rats treated with lambda cyhalothrin.…”

Section: Discussionsupporting

confidence: 92%

Deleterious Effect of Chlorpyrifos and Cypermethrin on Oxidative Stress Enzymes and Biochemical Indices of Male Albino Rats

Ikp¹,

Ude²,

Ok³

2015

J. of Medical Sciences

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This study was carried out to evaluate the effects of chlorpyrifos and cypermethrin, singly and in combination on oxidative stress enzymes and biochemical indices of male albino rats. 35 male albino rats weighing 170-200 g were divided into seven groups (A-G) of five rats each in a Completely Randomized Design. Rats in group A served as the control and received feed and distilled water only. Groups B and C received 5 and 10 mg of chlorpyrifos; groups D and E received 5 and 10 mg of cypermethrin, while groups F and G received 5 and 10 mg of combination (chlorpyrifos+cypermethrin), respectively. Treatment was administered via oral gavage and lasted for 65 days. At the end of treatment, the rats were sacrificed and blood samples were analyzed for oxidative stress enzymes and biochemical indices. On the one hand, result obtained for oxidative stress enzymes revealed that pesticide treatment significantly (p<0.05) reduced the levels of superoxide dismutase (SOD), Glutathione Peroxidase (GPx) and Catalase (CAT) activity and increased lipid peroxidation (MDA) level in rats treated with chlorpyrifos only. On the other hand, result for biochemical indices revealed that aspartate transaminase (AST) increased significantly (p<0.05) in the group of rats treated with 10 mg of chlorpyrifos and 5 mg of cypermethrin and reduced in those treated with 5 mg of chlorpyrifos and 10 mg of cypermethrin. Alkaline phosphatase (ALP) level reduced significantly in all the groups except for the group that received 5 mg of chlorpyrifos. While, alkaline transaminase (ALT) level increased significantly in some treated rats especially in the group that received 10 mg of the combination. Present findings therefore demonstrate that chlorpyrifos and cypermethrin could induce oxidative stress and alter the levels of some liver marker enzymes in male rats.

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“…proteins, microtubules, DNA) and subcellular organelles' membranes from oxidation and proteolysis. So, zinc suppressed ethanol-induced lipid peroxidation and glutathione depletion and reversed the ethanol-induced cGMP desensitization in fatty acid metabolism to prevent triacylglycerol accumulation which was discussed before by some authors [39,41,54,56] who mainly attributed this to accumulation of reactive oxygen species resulted from ethanol-induced oxidative stress. This came in harmony with some previous authors [28,64] who explained the markedly decreased incidence of degenerating-necrotic cells, apoptotic cells and inflammatory cells infiltration among zinc pretreated alcoholic group, by zinc preservation to intestinal barrier against endotoxins and in turn prevents their interaction with Kupffer cells to produce TNF-α which is responsible for stimulation of degeneration-necrosis, apoptosis and inflammation.…”

Section: Discussionmentioning

confidence: 83%

“…In addition, zinc suppresses necrosis through inhibiting lipid peroxidation and the oxidative stress process as being discussed before by some authors [51][52][53][54][55][56].…”

Section: Discussionmentioning

confidence: 99%

Histopathological and Histochemical Assessment of the Protective Effects of Zinc on Ethanol-Induced Acute Hepatotoxicity in Adult Albino Rats

Elshennawy¹,

Sayed²,

Saber³

et al. 2015

J Cytol Histol

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Impact of Oxidative Stress and Lipid Peroxidation Induced by Lambdacyhalothrin on P450 in Male Rats: The Ameliorating Effect of Zinc

Cited by 12 publications

References 41 publications

Effects of zinc supplementation on oxidant/antioxidant and lipids status of pesticides sprayers

Effects of zinc supplementation on oxidant/antioxidant and lipids status of pesticides sprayers

Deleterious Effect of Chlorpyrifos and Cypermethrin on Oxidative Stress Enzymes and Biochemical Indices of Male Albino Rats

Histopathological and Histochemical Assessment of the Protective Effects of Zinc on Ethanol-Induced Acute Hepatotoxicity in Adult Albino Rats

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