“…(3) The advanced glycation end-products (AGEs) are built up by the persistent increase in the blood glucose level, which In collagens, AGEs produce non-enzymatic cross-links thereby decreasing the flexibility of collagen matrix, which in turn leads to bone deformations. (4) As bone density and diabetes have an intricate interplay, Diabetic patients are often led to osteopenia and extreme cases are associated with osteoporosis. In turn, this results in facilitating the loss of bone in these patients and leads them to an increased level of risk for negative outcomes in terms of bone health.…”