Fe₃O₄/reduced graphene oxide-carbon nanotubes composite for the magnetic solid-phase extraction and HPLC determination of sulfonamides in milk

Abstract

A novel magnetic adsorbent Fe3O4/reduced graphene oxide‐carbon nanotubes, was prepared by one‐pot solvothermal synthesis method. It was characterized by scanning electron microscopy, X‐ray powder diffraction and vibrating sample magnetometry. The diameter of Fe3O4 microparticles was about 350 nm, which were covered by carbon nanotubes and reduced graphene oxide sheets, while carbon nanotubes inserted between the reduced graphene oxide sheets effectively prevented their aggregation. The composite had large surface area and good magnetic property, suiting for magnetic solid‐phase extraction and the determination of sulfonamides, by coupling with high‐performance liquid chromatography. Under the optimized conditions (including extraction time, amount of adsorbent, solution pH, ionic strength and desorption conditions), a good linear was achieved in the concentration range of 5–500 μg/L and the low limits of detection and low limits of quantification were 0.35–1.32 and 1.16–4.40 μg/L, respectively. The enrichment factors were estimated to be 24.72 to 30.15 fold. The proposed method was applied for the detection of sulfonamides in milk sample and the recoveries were 88.4–105.9%, with relative standard deviations of 0.74–5.38%.

Magnetic Solid-Phase Extraction of Organic Compounds Based on Graphene Oxide Nanocomposites

“…For this purpose, iron (III) chloride hexahydrate, sodium acetate, GO and CNTs were added in a Teflon-liner and the suspension was heated at 200 • C for 10 h. It was found that the Fe 3 O 4 nanoparticles were covered with RGO and CNTs, while CNTs were inserted between the RGO sheets in order to prevent the aggregation of the RGO sheets. The novel sorbent was used for the MSPE of sulfonamides from milk prior to their determination with HPLC-UV [73]. Pinsrithong and Bunkoed prepared a hierarchical porous polypyrrole-coated nanostructured composite of RGO and Fe 3 O 4 nanoparticles.…”

Trends in sensitive detection and rapid removal of sulfonamides: A review

“…The term molecularly imprinted polymer was further searched in the results of polymer. As shown, carbon [28,30,40,41,46,[107][108][109][110][111][112][113][114] materials are the most widely used adsorbents for enrichments of sulfonamides. Because the key for efficient enrichments of sulfonamides is to improve the adsorption capacity of the adsorbent, investigations of the adsorption properties and mechanisms are necessary.…”

“…Carbon materials used for sulfonamide enrichment include GO [40,[107][108][109][110][111][112][113][114][115][116][117][118][119], CNTs [30,33,46,110,111], graphene [112][113][114], and other carbon materials. These all possess the merits of good electrical, mechanical, physical, and chemical properties, and a very high surface to volume ratio [115].…”

“…Interestingly, magnetic materials [28,34,108,113] are welcome to be added into the materials mentioned above because of the advantage of their combination with MSPE, whose adsorbents are easily recycled and reused. In general, with A: 0.05% formic acid in water B: 0.05% formic acid in methanol 0.01-0.03 ng/g [144] the rapid development of novel adsorbents, it is believed that sulfonamide enrichment will be more effective, precise, and target specific in the future.…”

Magnetic solid‐phase extraction of tobacco‐specific N‐nitrosamines using magnetic graphene composite as sorbent

“…Graphene is a two‐dimensional honeycomb lattice material composed of carbon atoms . Due to the large specific area, good thermal and chemical stability, and π‐π electrostatic stacking properties graphene‐based materials have a variety of applications in modern sample preparation techniques , and graphene‐based sorbents have been used for extraction of polycyclic aromatic hydrocarbons , pesticide residues , mycotoxins , antibiotic drugs , nicotine , phytohormones , heavy metals , aromatic amines , and siloxanes in various samples. And recent studies have illustrated that graphene‐based materials have high adsorption capacity for TSNAs .…”