Failure to correlate
            <i>C. pneumoniae</i>
            with late onset Alzheimer’s disease

Taylor, Graham S.; Vipond, IB; Paul, Ian; Matthews, S. M.; Wilcock, G K; Caul, E.O.

doi:10.1212/wnl.59.1.142

Cited by 33 publications

(29 citation statements)

References 8 publications

(10 reference statements)

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“…60 Taylor et al attempted to revalidate Balin's results 4 years later by examining 10 of Balin's original AD cases (Table 3). 61 This study found the opposite results with no demonstration of C. pneumoniae nor amplification of Chlamydophila DNA by nested PCR. 61 Despite these tissue samples stemming from near the same location of Balin's, different methods of detecting C. pneumoniae and the strong possibility of PCR contamination likely led to these conflicting findings.…”

Section: Association Of C Pneumoniae and Alzheimer's Diseasecontrasting

confidence: 55%

“…61 This study found the opposite results with no demonstration of C. pneumoniae nor amplification of Chlamydophila DNA by nested PCR. 61 Despite these tissue samples stemming from near the same location of Balin's, different methods of detecting C. pneumoniae and the strong possibility of PCR contamination likely led to these conflicting findings. 60 Gerard et al demonstrated C. pneumoniae positive results by PCR in 80% of AD samples and 11.1% of the controls from Ann Arbor, Toronto, Los Angeles, and St. Paul (Table 3).…”

Section: Association Of C Pneumoniae and Alzheimer's Diseasecontrasting

confidence: 55%

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Association of Alzheimer's disease and Chlamydophila pneumoniae

Stallings

2008

Journal of Infection

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Section: Association Of C Pneumoniae and Alzheimer's Diseasecontrasting

confidence: 55%

Section: Association Of C Pneumoniae and Alzheimer's Diseasecontrasting

confidence: 55%

Association of Alzheimer's disease and Chlamydophila pneumoniae

Stallings

2008

Journal of Infection

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“…The authors suggest that the results of this study will perhaps allow a better understanding of the implications of infection with ChP in the etiology of AD [19]. However, the contribution of ChP to AD and VD pathology still remains questionable, especially as several studies using either PCR or immunochemical methods demonstrated the absence of the bacterium in the CNS and therefore concluded that this pathogen does not play any role in the development or exacerbation processes of AD and VD [10,26,30,31,34]. In order to explain such discrepancies, we investigated the presence of chlamydia DNA in the CSF of AD and VD patients.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of CSF-Chlamydia pneumoniae, CSF-tau, and CSF-Abeta42 in Alzheimer’s disease and vascular dementia

et al. 2007

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The potential role of microbiological factors such as Chlamydia pneumoniae (ChP) in the pathogenesis of neurodegenerative disorders, including Alzheimer's disease (AD) and vascular dementia (VD), has been suggested, but the correctness of this hypothesis still needs to be tested. In this study the appearance of ChP in the cerebrospinal fluid (CSF) of 57 AD and 21 VD patients and in 47 controls (CG) as well as the influence of ChP on the levels of tau protein and Abeta42 were investigated. The frequency of ChP occurrence in the AD patient group (43.9%) was significantly higher (p < 0.001) than in the control group (10.6%). In the case of VD patients, 9.5% of this group was positive for ChP. The presence of ChP DNA in the CSF of patients with AD significantly increases the occurrence of this disease (odds ratio = 7.21). Cerebrospinal fluid Abeta42 levels were significantly lower in patients with AD than in the CG (p < 0.001). Cerebrospinal tau protein was significantly higher in AD vs. CG (p = 0.007). However, no relationships between the presence of the bacterium in CSF and the level of either tau or Abeta42 protein were observed. In conclusion, we may suspect that testing for the presence of ChP in CSF, along with the tau and Abeta42 markers, may be used in the clinic diagnosis of AD.

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“…In 1998 Balin et al [27] found an extremely high association between the presence of C. pneumoniae in post-mortem brain samples and late-onset Alzheimer's disease. However, more recent studies have not repeated these findings [28-31]. A recent randomized controlled clinical trial [16], based on the hypothesis that chronic C. pneumoniae infection contributes to Alzheimer's disease, found an improved long-term cognitive state in patients with mild to moderate Alzheimer's disease who had been treated with doxycycline and rifampin.…”

Section: Discussionmentioning

confidence: 99%

Lack of association between vascular dementia and Chlamydia pneumoniae infection: a case-control study

et al. 2004

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Background: Chronic inflammation appears to play a role in the pathogenesis of vascular dementia. Given the association between Chlamydia pneumoniae and stroke, the possibility exists that previous exposure to C. pneumoniae may play a role in vascular dementia. The objective of this study was to determine if there was an association between serological evidence of C. pneumoniae infection or inflammatory markers with vascular dementia.

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Failure to correlate C. pneumoniae with late onset Alzheimer’s disease

Cited by 33 publications

References 8 publications

Association of Alzheimer's disease and Chlamydophila pneumoniae

Association of Alzheimer's disease and Chlamydophila pneumoniae

Evaluation of CSF-Chlamydia pneumoniae, CSF-tau, and CSF-Abeta42 in Alzheimer’s disease and vascular dementia

Lack of association between vascular dementia and Chlamydia pneumoniae infection: a case-control study

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