Fabrication of smart polymeric nanovectors to amplify intracellular oxidative stress for chemodynamic therapy

Hu, Jinming; Liu, Shiyong

doi:10.1360/ssc-2019-0152

Cited by 3 publications

(1 citation statement)

References 29 publications

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“…ROS have the capacity to inactivate a variety of pathogens [ 10 ]. Common ROS include singlet oxygen ( 1 O 2 ), hypochlorous acid (HClO), hydrogen peroxide (H 2 O 2 ), superoxide anion (O 2 •− ), and hydroxyl radical (•OH) [ 11 ]. In addition, some types of nanoparticles (NPs) have been engineered to interfere with the cellular homoeostasis and intracellular signaling pathways of bacterial cells, ultimately leading to the cell death [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Chemodynamic Therapy: Materials and Strategies

Chen¹,

2023

BME Front

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The wide and frequent use of antibiotics in the treatment of bacterial infection can cause the occurrence of multidrug-resistant bacteria, which becomes a serious health threat. Therefore, it is necessary to develop antibiotic-independent treatment modalities. Chemodynamic therapy (CDT) is defined as the approach employing Fenton and/or Fenton-like reactions for generating hydroxyl radical (•OH) that can kill target cells. Recently, CDT has been successfully employed for antibacterial applications. Apart from the common Fe-mediated CDT strategy, antibacterial CDT strategies mediated by other metal elements such as copper, manganese, cobalt, molybdenum, platinum, tungsten, nickel, silver, ruthenium, and zinc have also been proposed. Furthermore, different types of materials like nanomaterials and hydrogels can be adopted for constructing CDT-involved antibacterial platforms. Besides, CDT can introduce some toxic metal elements and then achieve synergistic antibacterial effects together with reactive oxygen species. Finally, CDT can be combined with other therapies such as starvation therapy, phototherapy, and sonodynamic therapy for achieving improved antibacterial performance. This review first summarizes the advancements in antibacterial CDT and then discusses the present limitations and future research directions in this field, hoping to promote the development of more effective materials and strategies for achieving potentiated CDT.

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Section: Introductionmentioning

confidence: 99%