Design of the tumor microenvironment-multiresponsive nanoplatform for dual-targeting and photothermal imaging guided photothermal/photodynamic/chemodynamic cancer therapies with hypoxia improvement and GSH depletion

Recent advances in hydrogels for preventing tumor recurrence

“…With the development of biomedical technologies, novel therapies like immunotherapy, photodynamic therapy, photothermal therapy, chemodynamic therapy, and targeted therapy are now emerging as promising anticancer approaches. 144,145 When combined with these therapies, hydrogels are expected to manifest better inhibitory effects of tumor recurrence and reduce side effects. In addition, after the surgical removal of tumors, it is usually accompanied by a series of symptoms such as skin injuries, wound bleeding, wound infection and inflammatory response.…”

Tumor Cell Targeting and Responsive Nanoplatform for Multimodal-Imaging Guided Chemodynamic/Photodynamic/Photothermal Therapy toward Triple Negative Breast Cancer

“…However, owing to the intrinsic irresponsive feature of TNBC and drawback of single treatment, , it is impractical to completely suppress tumor growth by monotherapy. Therefore, combination of multiple therapy methods toward TNBC is essential. , …”

All-in-one CoFe2O4@Tf nanoagent with GSH depletion and tumor-targeted ability for mutually enhanced chemodynamic/photothermal synergistic therapy

“…[23][24][25] Given that the Fenton response occurs rapidly only under adequate H 2 O 2 and acidic conditions, CDT can be uniquely adapted to the tumor microenvironment (TME) to facilitate the precise and selective treatment of tumors while minimizing injury to normal tissue. 26,27 At the same time, Fenton-type reactions are accelerated at elevated temperatures and are independent of light stimulation; thus, CDT can continuously treat cancer cells that are not destroyed by light therapy for facilitating PTT to provide a "1 + 1 > 2" therapeutic effect and can help prevent tumor recurrence and distant metastasis. [28][29][30][31][32][33] However, glutathione (GSH) with high antioxidant capacity is overexpressed in tumor cells, which would significantly compromise the synergistic therapeutic effect.…”