Tumor Cell Targeting and Responsive Nanoplatform for Multimodal-Imaging Guided Chemodynamic/Photodynamic/Photothermal Therapy toward Triple Negative Breast Cancer

Abstract

Triple negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, with ineffective treatment and poor prognosis. It is in great demand to develop a novel theranostic strategy for accurate diagnosis and targeted treatment of TNBC. In the present study, one nanoplatform (HA-ICG-Fe-PDA), endowed with multimodal imaging-guided chemodynamic/photodynamic/photothermal (CDT/PDT/PTT) synergistic therapy capacity toward TNBC, was innovatively constructed. The nanoplatform was prepared by covalently conjugating ICG-decorated hyaluronic acid (HA) on Fe3+-chelated polydopamine (PDA). HA facilitated the targeting and accumulating of the nanoplatform in tumor tissue and cells of TNBC, thus producing enhanced magnetic resonance signal. Upon entering into TNBC cells, the intracellular hyaluronidase-catalyzed cleavage of HA-ICG-Fe-PDA activated the prequenched near-infrared (NIR) fluorescence signal, allowing for the activatable NIR fluorescence imaging. On the other hand, Fe3+ in the nanoplatform could be reduced to reactive Fe2+ in tumor microenvironment, guaranteeing efficient Fenton reaction-mediated CDT. The combination of ICG with Fe-PDA enhanced the NIR absorption of the nanoplatform so that considerable PTT/PDT and photothermal imaging were achieved under 808 nm laser irradiation. In vitro and in vivo experiments have verified that the proposed nanoplatform integrates the potential of TNBC-targeting, precise NIR fluorescence/magnetic resonance/photothermal trimodal imaging, efficient treatment via synergistic CDT/PDT/PTT, as well as excellent biocompatibility. Therefore, this multifunctional nanoplatform provides a simple and versatile strategy for imaging-guided theranostics of TNBC.

Stimuli-Responsive Polymeric Nanomedicine for Enhanced Cancer Immunotherapy

“…Li et al demonstrated a tumor-targeting and responsive platform for trimodal imaging, including NIR fluorescence imaging, MRI, and photothermal imaging-guided chemodynamic therapy (CDT)/PDT/PTT. 92 Fe 3+ -chelated polydopamine (PDA) as the core was modified with indocyanine green (ICG)-conjugated HA. Fe 3+ for T 2weighted MRI, Fenton reaction-mediated CDT, ICG for the fluorescence imaging moiety, HA for active targeting, PDA for ICG quenching, and photothermal agents were used.…”

“…Li et al. demonstrated a tumor-targeting and responsive platform for trimodal imaging, including NIR fluorescence imaging, MRI, and photothermal imaging-guided chemodynamic therapy (CDT)/PDT/PTT . Fe 3+ -chelated polydopamine (PDA) as the core was modified with indocyanine green (ICG)-conjugated HA.…”

Recent advances and prospects of metal–organic frameworks in cancer therapies

“…Some studies have shown that combining chemodynamic therapy (CDT) and photodynamic therapy (PDT) can improve the antitumor efficacy. 84,85 High concentrations of hydrogen peroxide at the tumor site induce CDT through the Fenton reaction, producing more hydroxyl radicals and singlet oxygen. In contrast, PDT is performed under laser irradiation, and the photosensitizer conversion of light to heat energy increases the internal tumor temperature and produces toxic ROS.…”

From biomaterials to biotherapy: cuttlefish ink with protoporphyrin IX nanoconjugates for synergistic sonodynamic-photothermal therapy

“…2,4,5 Therefore, combined anticancer strategies exploring different therapeutic methods have shown overwhelming advantages over single therapeutic methods. 6,7 To date, various combinations of therapeutic strategies have emerged, such as SDT-PTT, 8,9 SDT-PDT, 10,11 PDT-PTT, 12,13 sonodynamic-chemodynamic therapy (SDT-CDT), 14,15 PDT-chemotherapy, 16,17 and SDT-chemotherapy. 18,19 In particular, PTT can enhance the production of reactive oxygen species (ROS), and SDT can compensate for the insufficient penetration of PTT to eradicate tumors in deep-seated tissues.…”