Dual-activity nanozyme to initiate tandem catalysis for doubly enhancing ATP-depletion anti-tumor therapy

Cong, Cong; Li, Chunhui; Cao, Guanghui; Liu, Chang; Yuan, Yi; Zhang, Xuwu; Wang, Desong; Gao, Dawei

doi:10.1016/j.bioadv.2022.213181

Cited by 7 publications

(5 citation statements)

References 25 publications

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“…In addition, many noble metal NPs, such as Pt, Pd, Ru, Rh, and Ir, also catalyze the oxidation of glucose and exhibit GOx activity. Ruthenium nanoparticles with GOx-like activity were reported for the first time by Cong et al 123 In the tumor microenvironment, Ru-based nanozyme with dual POD and GOx activities oxidized glucose to produce H 2 O 2 , which was then converted to •OH via a Fenton-like reaction. Glucose consumption was similar to "starvation treatment", and the synergistic effect with CDT significantly improved the antitumor efficacy of ruthenium nanozymes.…”

Section: Oxd-like Activitymentioning

confidence: 99%

Nanozymes for the Therapeutic Treatment of Diabetic Foot Ulcers

Xiao,

Zhao,

DuBois

et al. 2024

ACS Biomater. Sci. Eng.

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Diabetic foot ulcers (DFU) are chronic, refractory wounds caused by diabetic neuropathy, vascular disease, and bacterial infection, and have become one of the most serious and persistent complications of diabetes mellitus because of their high incidence and difficulty in healing. Its malignancy results from a complex microenvironment that includes a series of unfriendly physiological states secondary to hyperglycemia, such as recurrent infections, excessive oxidative stress, persistent inflammation, and ischemia and hypoxia. However, current common clinical treatments, such as antibiotic therapy, insulin therapy, surgical debridement, and conventional wound dressings all have drawbacks, and suboptimal outcomes exacerbate the financial and physical burdens of diabetic patients. Therefore, development of new, effective and affordable treatments for DFU represents a top priority to improve the quality of life of diabetic patients. In recent years, nanozymes-based diabetic wound therapy systems have been attracting extensive interest by integrating the unique advantages of nanomaterials and natural enzymes. Compared with natural enzymes, nanozymes possess more stable catalytic activity, lower production cost and greater maneuverability. Remarkably, many nanozymes possess multienzyme activities that can cascade multiple enzymecatalyzed reactions simultaneously throughout the recovery process of DFU. Additionally, their favorable photothermal-acoustic properties can be exploited for further enhancement of the therapeutic effects. In this review we first describe the characteristic pathological microenvironment of DFU, then discuss the therapeutic mechanisms and applications of nanozymes in DFU healing, and finally, highlight the challenges and perspectives of nanozyme development for DFU treatment.

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Section: Oxd-like Activitymentioning

confidence: 99%

Nanozymes for the Therapeutic Treatment of Diabetic Foot Ulcers

Xiao,

Zhao,

DuBois

et al. 2024

ACS Biomater. Sci. Eng.

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“…73 As a major energy source for cells, glucose plays an important role in the field of primary energy supply for biomedical organisms. The chemical structure of glucose was highly reactive due to the presence of multiple hydroxyl groups Glucose could be converted to H 2 O 2 under the action of catalysts such as GOX, 74 ruthenium, 75 and gold nanoparticles (AuNPs). 76 These bioactive enzymes could specifically recognize glucose and subsequently catalyze the transition from glucose to H 2 O 2 .…”

Section: Classification Of H 2 O 2 -Supplying Materialsmentioning

confidence: 99%

Advances in H₂O₂-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Zhang,

Li,

Tang

et al. 2024

Biomater. Sci.

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“…The research group led by Cong developed a Ru-based nanozyme with dual catalytic activities (glucose-oxidase-like activity and peroxidase-like activity). The nanozyme was loaded into nanoliposomes and modified with a tumor cell membrane to obtain Ru@ATO-Lip/M nanoparticles [ 50 , 51 ]. Ru exhibits GOx-like activity, strongly catalyzing the reaction between glucose and oxygen to generate H 2 O 2 .…”

Section: Fenton Reaction For the Treatment Of Malignant Tumorsmentioning

confidence: 99%

Advancements in the Application of the Fenton Reaction in the Cancer Microenvironment

Ou,

Aodeng,

2023

Pharmaceutics

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Cancer is a complex and multifaceted disease that continues to be a global health challenge. It exerts a tremendous burden on individuals, families, healthcare systems, and society as a whole. To mitigate the impact of cancer, concerted efforts and collaboration on a global scale are essential. This includes strengthening preventive measures, promoting early detection, and advancing effective treatment strategies. In the field of cancer treatment, researchers and clinicians are constantly seeking new approaches and technologies to improve therapeutic outcomes and minimize adverse effects. One promising avenue of investigation is the utilization of the Fenton reaction, a chemical process that involves the generation of highly reactive hydroxyl radicals (·OH) through the interaction of hydrogen peroxide (H2O2) with ferrous ions (Fe2+). The generated ·OH radicals possess strong oxidative properties, which can lead to the selective destruction of cancer cells. In recent years, researchers have successfully introduced the Fenton reaction into the cancer microenvironment through the application of nanotechnology, such as polymer nanoparticles and light-responsive nanoparticles. This article reviews the progress of the application of the Fenton reaction, catalyzed by polymer nanoparticles and light-responsive nanoparticles, in the cancer microenvironment, as well as the potential applications and future development directions of the Fenton reaction in the field of tumor treatment.

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Dual-activity nanozyme to initiate tandem catalysis for doubly enhancing ATP-depletion anti-tumor therapy

Cited by 7 publications

References 25 publications

Nanozymes for the Therapeutic Treatment of Diabetic Foot Ulcers

Nanozymes for the Therapeutic Treatment of Diabetic Foot Ulcers

Advances in H₂O₂-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Advancements in the Application of the Fenton Reaction in the Cancer Microenvironment

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Dual-activity nanozyme to initiate tandem catalysis for doubly enhancing ATP-depletion anti-tumor therapy

Cited by 7 publications

References 25 publications

Nanozymes for the Therapeutic Treatment of Diabetic Foot Ulcers

Nanozymes for the Therapeutic Treatment of Diabetic Foot Ulcers

Advances in H2O2-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications

Advancements in the Application of the Fenton Reaction in the Cancer Microenvironment

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Advances in H₂O₂-supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications