Expressão gênica de IGF-I e GHR no fígado e no músculo do peito de codornas de corte suplementadas com diferentes níveis de metionina em duas gerações sucessivas

Flora, Rostika; Dionello, Nelson José Laurino; Benitez, Letícia Carvalho; Germano, Jerusa Martins; Gotuzzo, Ariane; Freitas, S. C. de

doi:10.1590/1678-4162-9143

Cited by 5 publications

(3 citation statements)

References 22 publications

(11 reference statements)

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“…IGF-I and GH genes are known to be relevant in the production of functional substances, acting directly on the metabolism and growth of birds. However, dietary levels of excess methionine cause a decrease in growth, as it results in an amino acid imbalance, in addition to its excess it suffers an oxidation that promotes the production of sulfate, leading to a metabolic acidosis (Flora et al, 2017).…”

Section: Resultsmentioning

confidence: 99%

“…The amino acid imbalance caused by the excess or deficiency of methionine in the diets was limited to changes in the pullet's productive performance, where the treatments containing the methionine levels closer to the amino acid balance showed a better productive performance and metabolic activity. According to Flora et al (2017) high concentrations of methionine in the diet causes toxicity in birds, initially reducing feed intake and growth retardation.…”

Section: Resultsmentioning

confidence: 99%

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Digestible methionine levels for white-egg layer pullets from 7 to 12 weeks of age

Júnior

Guerra

Santana

et al. 2020

Acta Sci. Anim. Sci.

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An experiment was carried out to evaluate the requirement of digestible methionine for growing pullets at growth phase (7 to 12 weeks of age). A completely randomized design was distributed in five treatments, six replicates, and 15 pullets per experimental unit. 450 Dekalb White pullets from the 7th weeks of age, with an average initial weight of 313.14 ± 12.49 g were used. Dietary treatments consisted in five diets supplemented with DL-Methionine which resulted in five levels of digestible methionine (0.266, 0.294, 0.322, 0.350, and 0.378 %). Performance, serological blood, histopathology and histomorphometry data were evaluated. Quadratic responses were observed for final live weight (p < 0.0143), weight gain (p < 0.0073), feed conversion ratio (p < 0.0058), glycogen deposition in the liver (p < 0.0001), gamma-glutamyl transferase enzyme activity (p < 0.0008), and villus height (p < 0.0024) with digestible dMet levels. In conclusion, the use of 0.343 % dMet, corresponding to a dMet:dLys ratio 55, is recommended for white-egg pullets from 7 to 12 weeks of age.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Digestible methionine levels for white-egg layer pullets from 7 to 12 weeks of age

Júnior

Guerra

Santana

et al. 2020

Acta Sci. Anim. Sci.

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“…A S-adenosilmetionina (SAM) é um composto que dispõe de uma responsabilidade pelas metilações elementares para a biossíntese de uma diversidade de componentes que fazem parte dos quesitos celulares, como creatina, carnitina, fosfolipídeos e proteínas (Flora et al, 2017).…”

Section: Depressão E B12unclassified

Neurotransmissor serotonérgico em relação a doenças psíquicas e seus fatores nutricionais: uma revisão sistemática

Nascimento

2022

RSD

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A verificação do inquérito mediante a eficiência do neurotransmissor serotonina para com doenças neurológicas e transtornos concedeu-se resultâncias relevantes para a área de estudo do sistema nervoso, dado que a serotonina libera a sensação de bem-estar. Não obstante, a 5-hidroxitriptamina obteve relações com a parte nutricional de indivíduos com as doenças estudadas, assim, sucedeu-se um trabalho em conjunto para beneficiá-los. Objetivo: Investigar e compreender o neurotransmissor serotonina acerca dos problemas alimentares como melhoria para doenças e transtornos mentais. Metodologia: Trata-se de uma revisão sistemática com ambasamento na análise de 28 artigos dos anos de 2011 a 2020 em sites nacionais Scielo e BVS somado a livros da fisiologia, psicofarmacologia, anatomia e nutrição. Á vista disso, os resultados obtidos decorreu de que o sistema serotonérgico juntamente com a nutrição auxilia no tratamento da depressão, TEA, TDAH, SZC e DA. Conclusão: A serotonina atuando em soma com a alimentação mostra-se eficaz na melhora da saúde mental. Dessa forma, manter uma dieta conducente a saúde cerebral para a produção correta de serotonina é uma fator importante para o combate e prevenção.

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dl-Methionine supplementation in a low-fishmeal diet affects the TOR/S6K pathway by stimulating ASCT2 amino acid transporter and insulin-like growth factor-I in the dorsal muscle of juvenile cobia (Rachycentron canadum)

Chi

Tan

et al. 2019

Br J Nutr

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An 8-week feeding experiment was conducted to investigate the effects of dl-methionine (Met) supplementation in a low-fishmeal diet on growth, key gene expressions of amino acid transporters and target of rapamycin (TOR) pathway in juvenile cobia, Rachycentron canadum. Seven isonitrogenous and isolipidic diets were formulated, containing 0·72, 0·90, 1·00, 1·24, 1·41, 1·63 and 1·86 % Met. Weight gain and specific growth rates increased gradually with Met levels of up to 1·24 % and then decreased gradually. In dorsal muscle, mRNA levels of ASCT2 in the 1·00 % Met group were significantly up-regulated compared with 0·72, 1·63, and 1·86 %. The insulin-like growth factor-I (IGF-I) mRNA levels in the dorsal muscle of fish fed 1·00 and 1·24 % Met were higher than those in fish fed other Met levels. In addition, fish fed 1·24 % Met showed the highest mRNA levels of TOR and phosphorylation of TOR on Ser2448. The phosphorylation of ribosomal p70-S6 kinase (S6K) on Ser371 in the dorsal muscle of fish fed 1·86 % Met was higher than those in the 0·72 % group. In conclusion, straight broken-line analysis of weight gain rate against dietary Met level indicates that the optimal Met requirement for juvenile cobia is 1·24 % (of DM, or 2·71 % dietary protein). Met supplementation in a low-fishmeal diet increased cobia growth via a mechanism that can partly be attributed to Met’s ability to affect the TOR/S6K signalling pathway by enhancing ASCT2 and IGF-I transcription in cobia dorsal muscle.

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Expressão gênica de IGF-I e GHR no fígado e no músculo do peito de codornas de corte suplementadas com diferentes níveis de metionina em duas gerações sucessivas

Abstract: Expressão gênica de IGF-I e GHR no fígado e no músculo do peito de codornas de corte suplementadas com diferentes níveis de metionina em duas gerações sucessivas [IGF-I and GHR

Cited by 5 publications

References 22 publications

Digestible methionine levels for white-egg layer pullets from 7 to 12 weeks of age

Digestible methionine levels for white-egg layer pullets from 7 to 12 weeks of age

Neurotransmissor serotonérgico em relação a doenças psíquicas e seus fatores nutricionais: uma revisão sistemática

dl-Methionine supplementation in a low-fishmeal diet affects the TOR/S6K pathway by stimulating ASCT2 amino acid transporter and insulin-like growth factor-I in the dorsal muscle of juvenile cobia (Rachycentron canadum)

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