Experimental study comparing the tensile strength of different surgical meshes following aponeurotic-muscle deformity synthesis on Wistar rats

Abstract

PURPOSE: To assess the tensile strength of polypropylene and polypropylene associated with polyglactin meshes (Vypro II® - Ethicon®, Somerville, NJ, USA) in a situation of partial separation of abdominal muscle aponeurosis on rats. METHODS: Thirty rats were used of the Wistar strain, which were randomized into two groups of 15 specimens each. In both groups an aponeurotic-muscle deformity was created on the abdominal wall measuring 3.0 x 1.0 cm, which was closed with polypropylene mesh (polypropylene group) or Vypro® mesh (vypro group). After 28 days the rats underwent euthanasia and an area was removed from the abdominal wall with which a strip was made measuring 2.0 cm in length and 6.0 cm in width comprising the abdominal muscles with the implanted mesh. This sample was placed in a mechanical test machine in which a constant force was applied contrary to the tissue strips. Maximum force expressed in Newton was considered until full rupture of the sample occurred. The non-parametric Kruskal - Wallis test was used for statistical analysis admitting p<0.05. RESULTS: Out of the thirty animals, there were two deaths in the vypro group and one unit in the polypropylene group was lost. One animal in the polypropylene group developed hernia during the study and another one developed granuloma of the abdominal wall. All animals in both groups developed epiplon adherence to the mesh. The average force was 48.08 N for the polypropylene group and 45.32 for the vypro® group. CONCLUSION: In these experimental conditions it could be observed that there is no statistically significant difference in the rupture force of the polypropylene and Vypro® meshes (p=0.54).

Effect of copaiba oil on correction of abdominal wall defect treated with the use of polypropylene/polyglecaprone mesh

“…Currently, polypropylene meshes are the most used prosthesis for the correction of hernias 7 ; however, because they made of unabsorbed threads, these meshes cause a great immune response, which leads to the formation of large areas of fibrosis and decreased mobility of the abdominal wall 8 . Nevertheless, the use of meshes only made of absorbable threads did not show to be more efficient than meshes made of unabsorbed threads, since the first do not diminish the chances of relapses as the later 9 .…”

Peritoneal Adhesions Type I, Iii and Total Collagen on Polypropylene and Coated Polypropylene Meshes: Experimental Study in Rats

“…Postoperative adhesions have been reported as ranging from 20-50% for chronic pelvic pain to 74% for bowel obstruction. The use of barrier materials in an attempt to reduce adhesions has been constantly researched, but sometimes the results are contradictory 6 , 16 , 27 , 28 .…”

Biomaterials from Decellularized Tissues

“…These factors, in addition to matricryptic peptides generated during scaffold degradation, are believed to be at least partially responsible for the constructive remodeling response observed following ECM-derived biomaterial implantation. In contrast, synthetic scaffold materials, especially those which are slowly degradable or non-degradable and lack these beneficial biomolecules, tend to elicit a fibrotic and inflammatory response that inevitably leads to scar tissue formation and encapsulation [95][96][97][98][99][100][101].…”