Experimental and molecular docking studies on DNA binding interaction of adefovir dipivoxil: Advances toward treatment of hepatitis B virus infections

Binuclear copper(II) complexes: Synthesis, structural characterization, DNA binding and in silico studies

“…12 The molecular docking is used to model the interaction of the synthesized complexes with DNA, which gives information about the conformational changes in ligand and DNA when interact with each other. 13 Bromophenyl acetate is the derivative of the general class of phenyl acetic acid, which plays an important role in the growth of plants like auxin. 14 It is also used in the synthesis of non-steroidal anti-inflammatory drugs like Diclofenac (Voltaren), which have analgesic, antipyretic, and anti-inflammatory effect through cyclooxygenase inhibition.…”

Cobalt(III) complexes as potential anticancer agents: Physicochemical, structural, cytotoxic activity and DNA/protein interactions

“…Circular dichroic spectroscopy is a technique useful in diagnosing changes in DNA morphology during drug-DNA interactions, as the band due to base stacking (274 nm) and that due to right handed helicity (244 nm) are quite sensitive to the mode of DNA with small molecules [57]. The changes in CD signals ( where in the complex molecules stack in between the base pairs of DNA thus leading to an enhancement in the positive band [59].…”

Synthesis, molecular structure, theoretical calculation, DNA/protein interaction and cytotoxic activity of manganese(III) complex with 8-hydroxyquinoline

“…4. The positive absorption band at 274 nm and the negative one at 245 nm in the CD spectrum are due to the base stacking and the right-handed helicity of B-DNA, respectively[57,58]. The CD spectrum of CT DNA in presence of complex at 1:1 molar ratio shows an increase in positive band and decrease in negative band with a blue shift of 1, 2 nm for complex, compared to the CT DNA.…”