Synthesis, molecular structure, theoretical calculation, DNA/protein interaction and cytotoxic activity of manganese(III) complex with 8-hydroxyquinoline

Thamilarasan, Vijayan; Sengottuvelan, Nallathambi; Sudha, A.; Srinivasan, Pappu; Siva, Ayyanar

doi:10.1016/j.jphotobiol.2014.12.001

Cited by 15 publications

(4 citation statements)

References 65 publications

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“…Some metal elements with special biological activity are often used in the synthesis of heterocyclic complexes, such as the alkaline-earth-metal element magnesium (Mg 2+ ) and transition-metal elements manganese (Mn 2+ ), nickel (Ni 2+ ), zinc (Zn 2+ ), and copper (Cu 2+ ), − which are considered to be strong Lewis acids and can activate coordinated ligands for reactivity . Therefore, a series of heterocyclic metal complexes with practical and substantial applications have been widely used in agriculture (Figure ).…”

Section: Introductionmentioning

confidence: 99%

Design, Synthesis, and Antifungal Evaluation of 8-Hydroxyquinoline Metal Complexes against Phytopathogenic Fungi

Yin

Wang

et al. 2020

J. Agric. Food Chem.

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Phytopathogenic fungal infections have become a major threat to agricultural production, food security, and human health globally, and novel antifungal agents with simple chemical scaffolds and high efficiency are needed. In this study, we designed and synthesized 38 8-hydroxyquinoline metal complexes and evaluated their antifungal activities. The results showed that most of the tested compounds possessed remarkable in vitro antifungal activity. Especially, compound 1e exhibited the highest antifungal potency among all target compounds, with EC50 values of 0.0940, 0.125, 2.95, and 5.96 μg/mL, respectively, against Sclerotinia sclerotiorum, Botrytis cinerea, Fusarium graminearum, and Magnaporthe oryzae. Preliminary mechanistic studies had shown that compound 1e might cause mycelial abnormalities of S. sclerotiorum, cell membrane permeability changes, leakage of cell contents, and inhibition of sclerotia formation and germination. Moreover, the results of in vivo antifungal activity of compound 1e against S. sclerotiorum showed that 1e possessed higher curative effects than that of the positive control azoxystrobin. Therefore, compound 1e is expected to be a novel leading structure for the development of new antifungal agents.

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Section: Introductionmentioning

confidence: 99%

Design, Synthesis, and Antifungal Evaluation of 8-Hydroxyquinoline Metal Complexes against Phytopathogenic Fungi

Yin

Wang

et al. 2020

J. Agric. Food Chem.

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“…The percentage of cell viability (Figure 8) was reduced in a dose‐dependent manner after treatment with zinc complex, with an IC 50 value of 90.83 μM, confirming the zinc complex's specificity towards breast cancer cell line. The zinc complex was discovered to be most active at a concentration of μM, with a potential percent cell viability of reaching, indicating that the complex (SF.11) killed the majority of tumor cells at this concentration 54–56 . The missed ligand zinc complex has good intracellular DNA‐binding ability as well as in vitro cytotoxicity, indicating that the complex's biological target is triple‐helical DNA.…”

Section: Resultsmentioning

confidence: 99%

“…The zinc complex was discovered to be most active at a concentration of μM, with a potential percent cell viability of reaching, indicating that the complex (SF.11) killed the majority of tumor cells at this concentration. [54][55][56] The missed ligand zinc complex has good intracellular DNA-binding ability as well as in vitro cytotoxicity, indicating that the complex's biological target is triple-helical DNA.…”

Section: In Vitro Cytotoxicitymentioning

confidence: 99%

Mixed ligand octahedral Zn(II) complex of N^N^O donor tridentate Schiff base ligand and N^N donor bidentate bipyridine ligand: Synthesis, characterization, biological activity and cytotoxicity

Thamilarasan

Pugazhenthi

Nasirian

et al. 2022

Bulletin Korean Chem Soc

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Tridentate NNO donor Schiff base ligand and its mixed ligand zinc(II) complex were synthesized stoichiometrically and characterized by electronic, infrared, mass spectral techniques and elemental analysis. To understand the DNA binding ability, the complex was investigated by various analytical and spectroscopic techniques in presence of calf thymus DNA (CT‐DNA). The binding studies showed that the zinc complex interacts with DNA by groove binding mode with intrinsic binding strength of 2.11 × 105 M−1 and with bovine serum albumin the complex showed dynamic quenching attributed for changes in the secondary structure of BSA with efficient interaction. The MCF‐7 cell line studies of the zinc(II) complex with 90.8 μM IC50 value revealed that the complex is effective for the breast cancer cell line and has a potential as anticancer drug. Furthermore, the tridentate ligand and its mixed ligand zinc complex were screened for antibacterial and antifungal activities, which showed better antimicrobial activity for complex.

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“…Similarly, our synthesized oxalamide-based compound [OX(PID) 2 ] having comparative binding constants and LODs are mentioned below in Table S1 (ESI †). [31][32][33][34][35]…”

Section: Interference Studies Of Various Metal Ionsmentioning

confidence: 99%

An oxalamide-bridged imidazole based ‘turn off’ fluorescent receptor for copper(ii) and iron(iii) ions

et al. 2023

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Synthesis, molecular structure, theoretical calculation, DNA/protein interaction and cytotoxic activity of manganese(III) complex with 8-hydroxyquinoline

Cited by 15 publications

References 65 publications

Design, Synthesis, and Antifungal Evaluation of 8-Hydroxyquinoline Metal Complexes against Phytopathogenic Fungi

Design, Synthesis, and Antifungal Evaluation of 8-Hydroxyquinoline Metal Complexes against Phytopathogenic Fungi

Mixed ligand octahedral Zn(II) complex of N^N^O donor tridentate Schiff base ligand and N^N donor bidentate bipyridine ligand: Synthesis, characterization, biological activity and cytotoxicity

An oxalamide-bridged imidazole based ‘turn off’ fluorescent receptor for copper(ii) and iron(iii) ions

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