Exercise training to reduce sympathetic nerve activity in heart failure patients. A systematic review and meta-analysis

Abstract

HighlightsHeart failure is associated to autonomic dysfunction of cardiovascular system characterized by sympathetic hyperactivity.Exercise intervention promotes mechanisms that restores the autonomic balance.The effects of exercise training on sympathetic nerve activity in heart failure patients have not been summarized.In patients with heart failure, exercise training reduces sympathetic nerve activity compared with non-trained patients.The quality of evidence across the studies was moderate and the heterogeneity across the studies was high.

Aerobic Exercise Prevents Arterial Stiffness and Attenuates Hyperexcitation of Sympathetic Nerves in Perivascular Adipose Tissue of Mice after Transverse Aortic Constriction

“…Exercise training has been shown to normalize sympathetic hyperexcitation in patients with HF [ 16 ], and to restore PVAT function and prevent vascular complications [ 21 ]. Quantitative evidence from HF patients systematically supported this positive influence of exercise [ 22 ].…”

Effect of combined interval training on the cardiorespiratory fitness in heart failure patients: a systematic review and meta-analysis

“…On the other hand, RT is considered an important method for the improvement and maintenance of functional capacity, strength and muscle power in the elderly and patients with CHF. 9,45,46 Strength exercises combined with aerobic activity have been shown to promote better results related to body composition, muscle strength and CRF in individuals with obstructive coronary disease when compared to aerobic training alone. 47,48 Studies suggest that CT increases muscle function and aerobic capacity, by promoting greater efficiency of the body to use oxygen, 2,33 being effective for maintaining physical fitness and functional capacity 0 .…”

“…7,8 Thus, non-pharmacological treatment in the form of physical exercise is considered an indispensable therapeutic tool, which proves to be safe and inexpensive. 1,9 It is well reported that regular exercise increases muscle function and cardiorespiratory fitness (CRF), as well promotes greater body efficiency in using oxygen. 10 Therefore, different methods and protocols of exercises have been researched.…”

Associação entre os polimorfismos da enzima conversora da angiotensina e o comportamento da variabilidade da frequência cardíaca em indivíduos saudáveis: Uma revisão sistemática

“…Estratégias como o exercício físico vêm sendo exploradas no sentido de corroborar com o aumento da atividade parassimpática e redução da atividade simpática. De fato, um achatamento na descarga simpática tem sido uma das hipóteses para elucidar os mecanismos que explicam a queda da pressão arterial após uma sessão de treinamento físico (MacDonald, 2002) ou de forma crônica após um período de treinamento (Leosco et al, 2013;Saavedra et al, 2018) ilustrando assim a relevância da modulação autonômica no comportamento hemodinâmico do sistema cardiovascular. Ainda, os polimorfismos da ECA já foram associados com hipertensão arterial condição que pode plausivelmente ser explicada por uma hiperatividade simpática (Esler, 2000).…”