Evaluation of the safety, immunogenicity and efficacy of three capripoxvirus vaccine strains against lumpy skin disease virus

Gari, Getachew; Abie, Getnet; Gizaw, Daniel; Wubete, Alehegn; Kidane, Membere; Asgedom, Hagos; Bayissa, Berecha; Ayelet, Gelagay; Oura, Christopher; Roger, François; Tuppurainen, Eeva

doi:10.1016/j.vaccine.2015.01.035

Cited by 90 publications

(100 citation statements)

References 18 publications

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“…In cases where the local reactions at the vaccination site were very slight or not observed, it may also indicate that the vaccine virus was over-attenuated and therefore failed to produce an effective cell-mediated immune response. Also, highest DTH reaction responses in vaccinated calves were observed in the GC group, which indicated higher immunogenicity of the vaccine, and the lowest DTH reaction responses reaction observed with the SC group, might be related to the poor immunogenicity of the vaccines, resulting from lower antigenic similarity to LSD virus or over-attenuation resulting in genetic alteration leading to a failure in the generation of protective immunity (Tuppurainen et al, 2014;Gari et al, 2015).…”

Section: Discussionmentioning

confidence: 96%

Comparative efficacy of two heterologous capripox vaccines to control lumpy skin disease in cattle

Norian¹,

ahangran²,

Varshovi³

et al. 2019

BJVM

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Norian, R., N. Afzal Ahangran, H. R. Varshovi & A. Azadmehr, 2019. Comparative efficacy of two heterologous capripox vaccines to control lumpy skin disease in cattle. Bulg. J. Vet. Med., 22, No 2,[171][172][173][174][175][176][177][178][179] This longitudinal study was performed for field trial of heterologous vaccine strains of lumpy skin disease (LSD) to provide details on the characteristics of induced immune responses by measurement of specific antibody and target cytokines -critical parameters in immune response that can be related to the durability of protection. The experimental calves were vaccinated with Gorgan-GPV and RM/65-SPV vaccines and humoral and cellular immunity were evaluated weekly. In each vaccinated groups, cross-neutralising antibody titers against LSD virus (LSDV) could be detected, and this rate in GGPV-vaccinated calves (GC) was higher than RSPV-vaccinated calves (RC) in all weeks of experiments. The stimulation index and IFN-γ and IL-4 production in response to homologous virus were higher than to the heterologous virus in all time points. The highest difference between them was observed in RVC, and a significant difference were only shown at 21-day post vaccination (DPV) (P<0.001). The results of this study indicated that GGPV-vaccine had a good immunogenic response due to induction of high antibody titre and higher lymphocyte proliferation and IFN-γ and IL-4 production. Therefore, it was considered suitable to control LSD.

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Section: Discussionmentioning

confidence: 96%

Comparative efficacy of two heterologous capripox vaccines to control lumpy skin disease in cattle

Norian¹,

ahangran²,

Varshovi³

et al. 2019

BJVM

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show abstract

“…Lymphocyte proliferation in stimulated PBMCs is probably caused by recognition of conserved epitopes within or even between serotypes which have genetically relationship (26, 33). Lymphocyte MTT proliferation assay was chosen for estimation of cell mediated immune Response (7,30). Cell mediated immune response in vaccinated calves in goat poxvaccinated calves was higher than sheep poxvaccinated calves in all time point of experiment.…”

Section: Discussionmentioning

confidence: 99%

“…Lumpy skin disease is an infectious, eruptive, accationally fatal disaese of cattle and due to the rapid spread and ability to cause irreparable economic losses in livestock industry has been considered in "list A" of disease by OIE (3,4). The disease was first reported in 1929 in south of Africa in cattle and then spread in most of the central and northern of African countries (4)(5)(6), and recently through import of live cattle that carry the LSDV from endemic countries has been aggressively spreading in the Europe, India, south-west of Middle East and other countries (7). Several Capripoxvirus (CaPV) vaccine strains are used for the prevention and control of LSD.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Humoral and Cell-mediated Immunity of Two Capripoxvirus Vaccine Strains against Lumpy Skin Disease Virus

et al. 2016

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Background and Aims: Prevention of Lumpy skin disease (LSD) in cattle is heavily dependent on vaccination. Since the genetic structure of LSD virus has the close relatedness with other Capri-pox virus (CaPV). Therefore, the use of vaccine strains of CaPV derived from sheep and goat would be useful to protect cattle against LSD. Materials and Methods:The susceptible calves of dairy farms were vaccinated with two available LSD vaccines. These vaccines were live attenuated sheep pox and goat pox vaccine strains. To evaluate vaccine-induced immune responses, whole blood and serum samples were collected up to 5 weeks post vaccination from both vaccinated and control groups. Results: The findings showed that, lymphocyte proliferation index in response to recall antigen in goat pox vaccine was higher than sheep pox vaccine in all time-point of experiments, and this difference was significant in weeks 1 and 5 post vaccination (p<0.05). Although the levels of antibody production in both vaccinated groups was almost the similar, and there was no statistically significant difference, but in goat pox vaccine slightly higher than sheep pox vaccine. Also, the interferon gamma and IL-4 production in goat pox vaccine were higher than sheep pox vaccine in all-time point and statistically significant at week 3 post vaccination (p< 0.05). Conclusions: From this study we found that live attenuated goat pox vaccine induced high level of lymphocyte proliferation and interferon gamma and IL-4, so it considered good vaccine to control of Lumpy skin disease.

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“…This vaccine, however, caused adverse effects in 0.5% of the vaccinated cows, which was characterised by a very mild and transient LSD-like disease. A challenge study performed recently in Ethiopia showed that an attenuated Gorgon strain GTPV vaccine is effective in preventing LSD after challenge (Gari et al, 2015).…”

Section: Immune Response and Vaccines Against Lsdmentioning

confidence: 99%

Urgent advice on lumpy skin disease

2016

EFS2

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In order to assess the effects on disease spread and persistence of partial stamping out of only clinically affected animals in holdings where the presence of lumpy skin disease has been confirmed, against total stamping-out policy of infected herds coupled with vaccination, a mathematical model for the transmission of LSDV between farms was developed and different scenarios explored. According to the model, vaccination has a greater impact in reducing LSDV spread than any culling policy, even when low vaccination effectiveness is considered. When vaccination is evenly applied so that 95% of the farms are vaccinated with 75% of vaccinated animals effectively protected, then total stamping out and partial stamping out result in a similar probability of eradicating the infection. When no vaccination is applied or when vaccination has a lower effectiveness (e.g. 40%), the probability of eradication is higher when total stamping out is performed as compared to partial stamping out. In general, partial stamping out results in limited increase of the number of farms affected as compared to total stamping out. Independently of the culling interventions applied in the model, vaccination was most effective in reducing LSDV spread if protection had already been developed at the time of virus entry, followed by protection of herds after virus entry. No vaccination is the least effective option in reducing LSDV spread. In order to reach the above described effects, it is necessary to implement vaccination of the entire susceptible population in regions at risk for LSDV introduction or affected by LSDV in order to minimise the number of outbreaks, and high animal-and farm-level vaccination coverage should be achieved. Farmers and veterinarians should be trained in the clinical identification of LSD in order to reduce underreporting, and the effectiveness of partial stamping out should be evaluated under field conditions.

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Evaluation of the safety, immunogenicity and efficacy of three capripoxvirus vaccine strains against lumpy skin disease virus

Cited by 90 publications

References 18 publications

Comparative efficacy of two heterologous capripox vaccines to control lumpy skin disease in cattle

Comparative efficacy of two heterologous capripox vaccines to control lumpy skin disease in cattle

Evaluation of Humoral and Cell-mediated Immunity of Two Capripoxvirus Vaccine Strains against Lumpy Skin Disease Virus

Urgent advice on lumpy skin disease

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