Evaluation of biochemical and clinical effects of hyaluronic acid on non-surgical periodontal treatment: a randomized controlled trial

Aydınyurt, Hacer Şahin; Akbal, Damla; Altındal, Dicle; Bozoğlan, Alihan; Ertuğrul, Abdullah Seçkin; Demır, Halit

doi:10.1007/s11845-020-02230-6

Cited by 14 publications

(16 citation statements)

References 32 publications

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“…Hyaluronic acid and its salts (e.g., sodium hyaluronate) are used in oral care products, often in combinations with other ingredients (e.g., chlorhexidine), for plaque reduction and plaque control [ 74 , 75 , 76 , 77 , 78 ]. Several studies have shown that hyaluronic-acid-containing formulations can be used in the treatment and prevention of gingivitis/periodontitis [ 79 , 80 ]. For example, in combination with hydrogen peroxide, a hyaluronic-acid-containing mouthwash showed gingivitis-reducing effects [ 81 ].…”

Section: Overview On Adjunct Ingredients Used In Hydroxyapatite-based...mentioning

confidence: 99%

Overview on Adjunct Ingredients Used in Hydroxyapatite-Based Oral Care Products

2022

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Hydroxyapatite, Ca5(PO4)3(OH), is a biomimetic active ingredient, which is used in commercial oral care products such as toothpastes and mouthwashes worldwide. Clinical studies (in vivo) as well as in situ and in vitro studies have shown the preventive effects of hydroxyapatite in various field of oral care. In some products, hydroxyapatite is combined with other active ingredients, to achieve an additional antibacterial effect or to promote gum health. This review analyzes the efficacy of six selected natural and nature-inspired ingredients that are commonly used together with hydroxyapatite. These additional actives are either antibacterial (lactoferrin, xylitol, and zinc) or promote gum health (allantoin, bisabolol, and hyaluronic acid). A systematic literature search was performed, and all studies found on each ingredient were analyzed. In summary, all analyzed ingredients mentioned in this review are well described in scientific studies on their beneficial effect for oral health and can be used to expand the preventive effect of hydroxyapatite in oral care products.

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Section: Overview On Adjunct Ingredients Used In Hydroxyapatite-based...mentioning

confidence: 99%

Overview on Adjunct Ingredients Used in Hydroxyapatite-Based Oral Care Products

2022

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“…It is an attractive therapeutic option even in the field of dentistry owing to its pseudo-elasticity, viscoelasticity, biocompatibility, anti-inflammatory and bacteriostatic nature (5). HA forms a crucial element in the extracellular matrix of the soft tissues such as gingiva and periodontal ligament, while it is present in lesser quantities in the mineralized periodontal tissues of cementum and alveolar bone (3). The range of applications for HA in periodontal research are manifold and are summarized in this review.…”

Section: Introductionmentioning

confidence: 99%

“…This linear polysaccharide has multiple repeating disaccharide units [(1→3)-β-dGlcNAc-(1→4)-β-d-GlcA-](2). It is estimated that almost 15 grams of hyaluronic acid are present in the body of a normal adult weighing 70 kgs (3). It is produced by most of the cells in the human body, possibly contributing to various fundamental biological processes.…”

Section: Introductionmentioning

confidence: 99%

Potential for Hyaluronic Acid in Periodontal Research

Singh¹,

Roy²

2021

Preprint

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Hyaluronic acid, known also as hyaluronan, is the most abundant glycosaminoglycan in the extracellular matrix. It is produced by most of the cells in the human body, possibly contributing to various fundamental biological processes. This prompts interest in its therapeutic value. Hyaluronic acid (HA) has been used for various treatments owing to its broad range of properties in medical and dental field specially in periodontology. The review gives an overview on the effects of HA on fibroblasts, bone, wound healing, periodontal regeneration, aphthous ulcer/stomatitis and stem cells. Outcomes of including Hyaluronic acid in non-surgical periodontal therapy, drug delivery system and surgical procedures such as root coverage, papilla regeneration, root conditioning, intrabony defects, guided tissue regeneration are rather optimistic. HA has shown astounding potential in treating periimplantitis. Newer frontiers have to be explored to comprehend the other promising properties of HA. Keyword – Hyaluronic Acid, Periodontology.

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“…Moreover, this linear polysaccharide exhibits numerous repeating disaccharide units ( 3 ). Notably, a healthy adult (weight, 70 kg) possesses ~15 g HA in the body ( 4 ). The majority of cells in the human body synthesize HA; thus, it may play a role in a variety of key biological processes.…”

Section: Introductionmentioning

confidence: 99%

“…Notably, periodontal disease is an inflammatory disease involving the periodontium. The mineralized periodontal tissues of alveolar bone and cementum contain very little HA; however, it is necessitated by the extracellular matrix of the gingiva and the periodontal ligament ( 4 ). Wound healing is accelerated following treatment with HA, due to the subsequent impact on HA receptors, which play a role in cellular migration, angiogenesis and inflammation.…”

Section: Introductionmentioning

confidence: 99%

Role of hyaluronic acid in periodontal therapy (Review)

et al. 2022

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Hyaluronic acid (HA) is essential for the function of extracellular matrices in both hard and soft periodontal components. HA plays an important role in the mechanisms underlying inflammation and wound healing. HA is located in periodontal tissues in differing amounts, including non-mineralized tissues, such as gingiva and periodontal ligament, and lower levels located in mineralized tissues, such as cementum and alveolar bone. According to preliminary findings, HA exhibits potential in the regulation of periodontal tissue regeneration and in the treatment of periodontal disease. HA promotes symptomatic relief in both marginal gingiva and deeper periodontal tissues. The present review aimed to examine the role of HA in periodontal therapy, and investigate the current literature supporting its use in periodontal regeneration. Contents1. Introduction 2. Properties of HA 3. Synthesis of HA 4. Role of HA in wound healing 5. Role of HA and overview of studies in periodontal therapy 6. Conclusion

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Evaluation of biochemical and clinical effects of hyaluronic acid on non-surgical periodontal treatment: a randomized controlled trial

Cited by 14 publications

References 32 publications

Overview on Adjunct Ingredients Used in Hydroxyapatite-Based Oral Care Products

Overview on Adjunct Ingredients Used in Hydroxyapatite-Based Oral Care Products

Potential for Hyaluronic Acid in Periodontal Research

Role of hyaluronic acid in periodontal therapy (Review)

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