The natural surface of human hair (epicuticle) consists of a bilayer of heavily cross-linked proteins toward the individual cuticle cell inside combined with a monomolecular, hydrophobic layer of mixed fatty acids to the outside (F-layer), which is generally assumed to be homogeneous. Wetting force profiles along segments of hair from female test persons with lengths equivalent to about 1 month of growth (approximately 10 mm) are presented. In a multistep analysis, applying curve smoothing as well as Fourier and principal components analysis, for hair lengths comprising daily and weekly growth (2 mm) pronounced systematic changes are observed in the profiles, which show that the wettability curves are nonstochastic in nature and that hair exhibits a strongly nonhomogeneous surface. Specifically, a compound daily rhythm is observed for wettability, which through its typical bimodality can be linked to continuous changes of the hair surface during wake and sleep phases. The data set furthermore suggests systematic monthly changes, which may be related to the menstrual cycle. In consequence, the results not only provide proof for the inhomogeneity of the immediate hair surface but also lead to the hypothesis that it preserves a rather detailed and long-term, individual chronobiological record, through a specific, spatially modulated distribution of hydrophobic (lipids) and hydrophilic (proteins) regions, "written" by the composition of the cell membrane of the cuticle cell prior to apoptosis.

The human body needs calcium and phosphate as essential nutrients to grow bones and teeth, but they are also necessary for many other biochemical purposes (e.g., the biosynthesis of phospholipids, adenosine triphosphate, ATP, or DNA). The use of solid calcium phosphate in particle form as a food additive is reviewed and discussed in terms of bioavailability and its safety after ingestion. The fact that all calcium phosphates, such as hydroxyapatite and tricalcium phosphate, are soluble in the acidic environment of the stomach, regardless of the particle size or phase, means that they are present as dissolved ions after passing through the stomach. These dissolved ions cannot be distinguished from a mixture of calcium and phosphate ions that were ingested separately, e.g., from cheese or milk together with soft drinks or meat. Milk, including human breast milk, is a natural source of calcium and phosphate in which calcium phosphate is present as nanoscopic clusters (nanoparticles) inside casein (protein) micelles. It is concluded that calcium phosphates are generally safe as food additives, also in baby formula.

Hair shine or luster is perceived as an important, though analytically somewhat elusive, attribute of beauty, primarily associated with clean and healthy hair. Principles for the assessment of hair luster are developed that are consistent with the practical situation. These principles are related to the components of light, specularly and diffusely reflected from single hair fibers, as measured by laser‐based, multiangle goniophotometry, presented in Part I. Considering various definitions of gloss, their tradition, practical implementation, and their inherent limitations for testing hair, the gloss index as a physically consistent measure of hair luster is derived from the ratio of the integral intensities of the light components. Changes of the parameter values along hair length, namely their decrease, are analyzed for hairs of different color and ethnic origin. The correlation with shine evaluations of hair tresses by panels, based on literature data, is analyzed and ascertained.

Molar incisor hypomineralization (MIH) is a highly prevalent dental developmental disorder with a significant health burden for patients and high treatment needs, yet no comprehensive review article on all remineralization systems as a non-invasive treatment approach for MIH has been published. Typical characteristics of MIH-affected teeth are a lower mineral density and lower hardness compared to healthy teeth leading to sensitivity and loss of function. Thus, the use of formulations with calcium phosphates to remineralize MIH-affected teeth is reasonable. This review presents an up-to-date overview of remineralization studies focusing on active ingredients investigated for remineralization of MIH, i.e., casein phosphopeptide amorphous calcium phosphate (CPP-ACP), casein phosphopeptide amorphous calcium fluoride phosphate (CPP-ACFP), hydroxyapatite, calcium glycerophosphate, self-assembling peptide, and fluoride. Overall, 19 studies (in vitro, in situ, and in vivo) were found. Furthermore, an additional search for studies focusing on using toothpaste/dentifrices for MIH management resulted in six studies, where three studies were on remineralization and three on reduction of sensitivity. Overall, the studies analyzed in this review showed that MIH-affected teeth could be remineralized using calcium phosphate-based approaches. In conclusion, calcium phosphates like CPP-ACP, calcium glycerophosphate, and hydroxyapatite can be used to remineralize MIH-affected teeth. In addition to MIH-remineralization, CPP-ACP and hydroxyapatite also offer relief from MIH-associated tooth sensitivity.

Hydroxyapatite, Ca5(PO4)3(OH), is a biomimetic active ingredient, which is used in commercial oral care products such as toothpastes and mouthwashes worldwide. Clinical studies (in vivo) as well as in situ and in vitro studies have shown the preventive effects of hydroxyapatite in various field of oral care. In some products, hydroxyapatite is combined with other active ingredients, to achieve an additional antibacterial effect or to promote gum health. This review analyzes the efficacy of six selected natural and nature-inspired ingredients that are commonly used together with hydroxyapatite. These additional actives are either antibacterial (lactoferrin, xylitol, and zinc) or promote gum health (allantoin, bisabolol, and hyaluronic acid). A systematic literature search was performed, and all studies found on each ingredient were analyzed. In summary, all analyzed ingredients mentioned in this review are well described in scientific studies on their beneficial effect for oral health and can be used to expand the preventive effect of hydroxyapatite in oral care products.