Overview on Adjunct Ingredients Used in Hydroxyapatite-Based Oral Care Products

Enax, Joachim; Wiesche, Erik Schulze zur; Meyer, Frederic

doi:10.3390/biomimetics7040250

Cited by 5 publications

(5 citation statements)

References 111 publications

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“…There is limited evidence that the pellicle might also be a reservoir for carbohydrates (i.e., sugars). While some of those sugars (e.g., xylitol) might be protective, others might enhance the caries-process, namely glucose or lactose ( 59 , 60 ). It can be assumed that carbohydrates content of the pellicle are mainly derived from diet and will be metabolized by oral bacteria for their energy supply.…”

Section: Discussionmentioning

confidence: 99%

The composition of the dental pellicle: an updated literature review

Enax,

Ganss,

Amaechi

et al. 2023

Front. Oral. Health

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BackgroundThe dental pellicle is a thin layer of up to several hundred nm in thickness, covering the tooth surface. It is known to protect the teeth from acid attacks through its selective permeability and it is involved in the remineralization process of the teeth. It functions also as binding site and source of nutrients for bacteria and conditioning biofilm (foundation) for dental plaque formation.MethodsFor this updated literature review, the PubMed database was searched for the dental pellicle and its composition.ResultsThe dental pellicle has been analyzed in the past years with various state-of-the art analytic techniques such as high-resolution microscopic techniques (e.g., scanning electron microscopy, atomic force microscopy), spectrophotometry, mass spectrometry, affinity chromatography, enzyme-linked immunosorbent assays (ELISA), and blotting-techniques (e.g., western blot). It consists of several different amino acids, proteins, and proteolytic protein fragments. Some studies also investigated other compounds of the pellicle, mainly fatty acids, and carbohydrates.ConclusionsThe dental pellicle is composed mainly of different proteins, but also fatty acids, and carbohydrates. Analysis with state-of-the-art analytical techniques have uncovered mainly acidic proline-rich proteins, amylase, cystatin, immunoglobulins, lysozyme, and mucins as main proteins of the dental pellicle. The pellicle has protective properties for the teeth. Further research is necessary to gain more knowledge about the role of the pellicle in the tooth remineralization process.

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Section: Discussionmentioning

confidence: 99%

The composition of the dental pellicle: an updated literature review

Enax,

Ganss,

Amaechi

et al. 2023

Front. Oral. Health

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“…Lactoferrin may be a very valuable alternative BAS to be introduced in collagen membranes for oral soft tissue regeneration. LF is a safe therapeutic agent that has already proved its effectiveness in clinical trials for wound regeneration in patients with skin and ligament injuries [26,27], is available for commercial production in large scales while keeping the final price inexpensive [28,29], and is already used in dentistry as an active ingredient for mouthwashes [30]. In our study, the incorporation of LF into the structure of collagen membranes by SBA-EPD was possible, since collagen and lactoferrin behave similarly in an electric field when dissolved in an acidic medium.…”

Section: Discussionmentioning

confidence: 99%

Electrophoretically Co-Deposited Collagen–Lactoferrin Membranes with Enhanced Pro-Regenerative Properties for Oral Soft Tissue Regeneration

Antoshin,

Gostev,

Khristidis

et al. 2023

IJMS

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The quality of soft tissue defect regeneration after dental surgeries largely determines their final success. Collagen membranes have been proposed for the healing of such defects, but in some cases, they do not guarantee a sufficient volume of the regenerated tissue and vascularization. For this purpose, lactoferrin, a protein with natural pro-regenerative, anti-inflammatory, and pro-angiogenic activity, can be added to collagen. In this article, we used a semipermeable barrier-assisted electrophoretic deposition (SBA-EPD) method for the production of collagen–lactoferrin membranes. The membrane structure was studied by SEM, and its mechanical properties were shown. The lactoferrin release kinetics were shown by ELISA within 75 h. When tested in vitro, we demonstrated that the collagen–lactoferrin membranes significantly increased the proliferation of keratinocytes (HaCaT) and fibroblasts (977hTERT) compared to blank collagen membranes. In vivo, on the vestibuloplasty and free gingival graft harvesting models, we showed that collagen–lactoferrin membranes decreased the wound inflammation and increased the healing rates and regeneration quality. In some parameters, collagen–lactoferrin membranes outperformed not only blank collagen membranes, but also the commercial membrane Mucograft®. Thus, we proved that collagen–lactoferrin membranes produced by the SBA-EPD method may be a valuable alternative to commercially used membranes for soft tissue regeneration in the oral cavity.

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“…Other milk components such as lactoferrin, lysozyme, and lactoperoxidase may contribute to milk anti-cariogenicity, due to their antibacterial effect ( Table 2 ) [ 16 , 57 , 64 , 65 , 66 , 67 , 68 ]. Lactoferrin is often used as an ingredient in oral many commercial products including toothpaste [ 68 ]. Lactoferrin for commercial use is primarily extracted from bovine milk [ 67 ].…”

Section: Influence Of Components Of Dairy Products and Plant-based Al...mentioning

confidence: 99%

Impact of Dairy Products and Plant-Based Alternatives on Dental Health: Food Matrix Effects

Shkembi

Huppertz

2023

Nutrients

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The impact of dairy products on dental health has been researched widely and shows an important role of various constituents, as well as the specific product matrix, in maintaining and improving dental health. These include, for instance, the position of lactose as the least cariogenic fermentable sugar, the high levels of calcium and phosphate, the presence of phosphopeptides as well as the antibacterial peptides lactoferrin and lysozyme and high buffering capacity. With plant-based alternatives for dairy products being developed and marketed these days, the specific benefits of dairy products in relation to dental health are often overlooked and most products contain more cariogenic carbohydrates, lack phosphopeptides, and have fewer minerals and less buffering capacity. Comparative studies performed to date indeed suggest that plant-based products do not match dairy counterparts when it comes to maintaining and improving dental health. Careful consideration of these aspects is required in relation to future developments of products and human diets. In this paper, we review the impact of dairy products and plant-based dairy alternatives on dental health.

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Overview on Adjunct Ingredients Used in Hydroxyapatite-Based Oral Care Products

Cited by 5 publications

References 111 publications

The composition of the dental pellicle: an updated literature review

The composition of the dental pellicle: an updated literature review

Electrophoretically Co-Deposited Collagen–Lactoferrin Membranes with Enhanced Pro-Regenerative Properties for Oral Soft Tissue Regeneration

Impact of Dairy Products and Plant-Based Alternatives on Dental Health: Food Matrix Effects

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