Potential for Hyaluronic Acid in Periodontal Research

Singh, Shruti; Roy, R.

doi:10.20944/preprints202102.0094.v1

Cited by 1 publication

(2 citation statements)

References 22 publications

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“…One of the benefits of HA is its use in nonsurgical periodontal therapy as a drug delivery system. Its effectiveness is also evident in surgical procedures such as gingival recession coverage, papilla tissue regeneration, root conditioning, 21 and infrabony defects. 20 In fact, HA has been proven effective in treating implant-related inflammation.…”

Section: Introductionmentioning

confidence: 99%

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Effectiveness of 0.2% Hyaluronic Acid on Clinical, Biomolecular and Microbiological Parameters in Type 2 Diabetes Mellitus Patients with Periodontitis

Devina,

Halim,

Meivi

et al. 2024

Eur J Dent

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Objective This double-blind randomized clinical trial assessed the effectiveness of 0.2% hyaluronic acid (HA) gel as an adjunct to scaling and root planning (SRP) in patients with periodontitis and type 2 diabetes mellitus (DM), focusing on changes in clinical periodontal parameters, the expression of inflammatory mediators, and oral pathogens. Materials and Methods The randomized clinical trial involved 36 participants, 18 DM patients, and 18 healthy patients. The participants in each group were randomly assigned to receive placebo or HA gel after SRP. Gingival crevicular fluid and subgingival plaque samples were taken before treatment and at 4-week follow-up. Clinical parameters, interleukin-1β (IL-1β) and IL-10 levels, and proportions of Porphyromonas gingivalis (Pg) and Fusobacterium nucleatum (Fn) were evaluated at baseline and follow-up. Statistical Analysis Paired t-test (parametric data) or Wilcoxon signed-rank test (nonparametric data) was used for intragroup comparison between baseline and follow-up, and comparisons between groups one-way analysis of variance test (parametric data) or Kruskal–Wallis test (nonparametric data). Results At 4 weeks, most of the groups showed statistically significant decreases (p ≤ 0.05) in various clinical and biomolecular parameters. However, there were exceptions: the pocket probing depth (PPD) and clinical attachment loss (CAL) parameter did not significantly decrease for the placebo (p > 0.05) non-DM group, and the IL-10 parameter in the DM HA gel group (p = 0.108). Regarding bacterial proportions, the non-DM and DM placebo group exhibited significant test results for Pg after 4 weeks (p ≤ 0.05). In the case of Fn bacteria proportions, they decreased in all groups, but these results were not statistically significant (p ≥ 0.05). An intergroup analysis revealed no significant differences (p ≤ 0.05) for bleeding on probing (BOP), PPD, and both proinflammatory and anti-inflammatory cytokines. Only clinical attachment loss (CAL) exhibited a statistically significant intergroup difference 0.042. Conclusion The use of 0.2% HA gel into periodontal pockets alongside SRP, for both diabetic and healthy individuals, showed no statistically significant variances in clinical, biomolecular, and microbiological measures.

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Section: Introductionmentioning

confidence: 99%

“…20 In fact, HA has been proven effective in treating implant-related inflammation. 21 HA can also provide anti-inflammatory, antiedema, and anti-bacterial effects for individuals with gingivitis and periodontitis. 18 In patients with DM and periodontitis, there are often impediments to the healing process.…”

Section: Introductionmentioning

confidence: 99%