Evaluation of antibiotic susceptibility in wound infections: A pilot study from Bangladesh

Abstract

Introduction: Infections due to antibiotic resistant bacteria have increased alarmingly in both developed and developing countries. Unrestrained and rapidly spreading bacterial growth has turned the management of wound infections into a serious challenge. This study aimed to determine the prevalence of different bacterial pathogens and their antibiotic susceptibility in various types of wound infections. Methods: A cross-sectional study was conducted to collect 105 wound swabs. All isolated bacteria were identified based on colony characteristics, gram stain and standard biochemical tests, and antibiotic susceptibility testing (AST) with the disc diffusion method. Descriptive statistics were used to present the study findings, and all analyses were performed using Stata Version 13. Results: The rate of isolation of bacteria was 92.3%. Staphylococcus aureus was found to be the most frequent isolate (55.7%), followed by Escherichia coli (23.7%), Pseudomonas spp. (8.2%), and Streptococcus pyogenes (7.2%). Gram-positive bacteria were mostly (60%) found sensitive to vancomycin, azithromycin, gentamicin, imipenem, cefixime, and ceftriaxone in this study. Among the Gram-negative bacteria, Escherichia coli (>60%) showed sensitivity to cefixime, azithromycin, cefuroxime, ceftriaxone, cefotaxime, gentamycin, and ceftazidime. Conclusions: The diversity of isolated bacteria and their susceptibility patterns signify a need to implement a proper infection control strategy, which can be achieved by carrying out antibiotic sensitivity tests of the isolates.

Investigation of antibiotic resistance pattern of Staphylococcus aureus in clinical samples of animals and humans from selective areas of Bangladesh

“…Besides penicillin, other tested antibiotics showed some form of resistance (multidrug-resistant) against S. aureus which is similar to the findings of previous studies (Erami et al, 2014;Neyra et al, 2014;Chen et al, 2016;Roy et al, 2017;Anueyiagu et al, 2020). The lowest percentage of animal origin S. aureus were resistant to oxacillin and the lowest percentage of human origin S. aureus were resistant to fusidic acid.…”

Investigation of the Bacterial Contamination and Antibiotic Susceptibility Profile of Bacteria Isolated from Bottled Drinking Water

“…The results of this study are comparable with those of other published studies ( 16 , 17 ). In contrast, the outcome of this study contradicted with ( 18 ) study as the authors have reported that the Escherichia coli isolates showed sensitivity to cefixime, azithromycin, cefotaxime and ceftazidime. The difference can be explained by the fact that the isolation site as the cited study has isolated the Escherichia coli from wound infections whereas the current study from bottled water.…”

Evaluation of bacterial culture and their resistant pattern in pus containing patients of different wards of the hospital, Lahore, Pakistan

“…Similarly, in previous work they were resistant to methicillin but all sensitive to Vancomycin (Javeed et al, 2011). Similarly Roy et al (2017) stated that 59.1% for cotrimoxazole and 66.2% resistant to tetracycline but in present study resistant to amoxicillin is 88.8% while resistant to ceftrizidime is 85%. Getachew et al (2018) reported that resistance of S. aureus to methicillin continuously increased day by day and also show multidrug resistant pattern against common antibiotics.…”

“…Pus consists of a buildup of dead leukocytes (white blood cells) from the body's immune system in response to infection. Pus forming bacteria are called Pyogenic (Madigan and Martin, 2006 (Roy et al, 2017).…”