Epidemiology of Dyslipidemia in the Asia Pacific Region

Lin, Chiou–Feng; Chang, Ya Hui; Chien, Shih Chieh; Lin, Yueh Hung; Yeh, Hung Yi

doi:10.1016/j.ijge.2018.02.010

Cited by 121 publications

(131 citation statements)

References 18 publications

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“…Hypercholesterolemia is a condition characterized by an elevation of total cholesterol (TC) and/or low-density lipoprotein cholesterol (LDL-C) or non-high-density lipoprotein cholesterol (HDL-C) in the blood [30]. Non-HDL-C is defined as the subtraction of HDL-C from TC [30,31]. Hypercholesterolemia is a contributing factor to CVD.…”

Section: Effects Of Tocotrienol On Lipid Metabolismmentioning

confidence: 99%

Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence

et al. 2020

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Tocotrienol (T3) is a subfamily of vitamin E known for its wide array of medicinal properties. This review aimed to summarize the health benefits of T3, particularly in prevention or treatment of non-communicable diseases (NCDs), including cardiovascular, musculoskeletal, metabolic, gastric, and skin disorders, as well as cancers. Studies showed that T3 could prevent various NCDs, by suppressing 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) in the mevalonate pathway, inflammatory response, oxidative stress, and alternating hormones. The efficacy of T3 in preventing/treating these NCDs is similar or greater compared to tocopherol (TF). TF may lower the efficacy of T3 because the efficacy of the combination of TF and T3 was lower than T3 alone in some studies. Data investigating the effects of T3 on osteoporosis, arthritis, and peptic ulcers in human are limited. The positive outcomes of T3 treatment obtained from the preclinical studies warrant further validation from clinical trials.Nutrients 2020, 12, 259 2 of 84 Nutrients 2020, 12, 259 4 of 84 the order δ > γ > β > α [45]. Using HepG2 cells, γT3 was shown to stimulate apolipoprotein B (Apo-B) degradation by decreasing its translocation into the endoplasmic reticulum (ER) lumen. This action eventually caused a reduction in the number of Apo-B in lipoprotein particles [46]. Other reports showed that γT3 and δT3 had the potential to reduce the hepatic TG synthesis and very-low-density lipoprotein (VLDL) secretion by suppressing expression of genes involved in lipid homeostasis, particularly the TG, cholesterol, and VLDL biosynthesis. Moreover, δT3 also promoted the efflux of LDL through LDL receptor expression [47]. A summary of the literature on effect of T3 supplementation on lipid profile of hypercholesterolemic model in vitro is shown in Table 1.Animal models of dyslipidemia have been used to investigate the effects of T3 on lipid profile. Several animals have been tested, including chicken, swine and rodents (rats, hamsters, guinea pigs). In chickens fed with a varying level of αTF and γT3, Qureshi et al. (1996) showed that αTF enhanced the inhibition of HMGCR by γT3. They further stipulated that the vitamin E mixture should contain 15-20% of αTF and approximately 60% of γT3 or δT3 for optimal anti-cholesterol effects [48]. In the subsequent study, demonstrated that combination of 50 ppm T3-rich fraction (TRF) and 50 ppm lovastatin was more effective in suppressing HMGCR activity compared to lovastatin alone in chickens. The combination also reduced serum TC and LDL-C, TG, Apo-B, thromboxane B 2 , and platelet factor 4 in contrast to individual treatment [49]. Using chicken supplemented with 50 ppm of δT3, Qureshi et al. (2011) further revealed that δT3 reduced TC and LDL-C besides suppressing the lipid elevating effects of dexamethasone and potentiated the TG-lowering effect of riboflavin [50]. Using genetically hypercholesterolemic swine, Qureshi et al. (1991) demonstrated the significant effect of TRF in lowering serum TC, LDL-C, Apo-B, thrombo...

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Section: Effects Of Tocotrienol On Lipid Metabolismmentioning

confidence: 99%

Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence

et al. 2020

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“…Moreover, triglycerides and waist circumference often correlates positively [25]. In various studies in several Asian countries, prevalence of women with hypertriglyceridemia was almost close to the prevalence in men [14]. According to Riskesdas (National Baseline Health Research) in 2013, the prevalence of hypertriglyceridemia in Indonesia among women was 11.7% which was not significantly different from prevalence among men, i.e.…”

Section: Introductionmentioning

confidence: 96%

Effect of Soy Milk and Mung Bean Porridge on Serum Triglycerides among Postmen-opausal Women

Syailawan

Mostafa²,

Kartikasari³

2019

AJNE

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“…3,4 it is reported that by the year of 2015, cardiovascular artery disease will be responsible for 20 million deaths approximately, mainly from strokes and heart attacks. 5 some of the contributing factors commonly correlated with the evolution of atherosclerosis and cardiovascular diseases include elevated lipid profile, high blood pressure and diabetes mellitus, 6,7,8,9 tobacco use, obesity, 10 physical inactivity. 11 Major common elements for development of cardiac ischemia and acute coronary artery diseases are continuously rising in pakistan.…”

Section: Introductionmentioning

confidence: 99%

Role of simvastatin and allium sativum on lipid profile in diabetic dyslipidemic patients: a comparative study.

Siddiqui

Taj

Ishaque

et al. 2020

TPMJ

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Objectives: To evaluate the changes in lipid profile in patients with diabetic dyslipidemia using lipid lowering drug, simvastatin and herbal product allium sativum. Study Design: Clinical trial. Setting: Surgeon Munawar Memorial Hospital, Karachi. Period: 1st January 2017 to 30th April 2017. Material & Methods: The study was designed to assess the effects of hmg-coa reductase inhibitor (simvastatin) and allium sativum on lipid profile in patients with diabetic dysplipidemia. The exclusion criteria included lactating/pregnant women’s, renal, liver and established coronary artery disease. Results: Sixty patients with abnormal lipid profile were included in the study (age 30-60 years). Patients were divided into two groups (30 patients each). Group a was orally administered with product of simvastatin (20 mg)/day for 04 months and in group b, patients were orally administered with herbal product of allium sativum (300 mg)/day for 04 months. Conclusion: On the basis of this study it is observed that allium sativum as well as simvastatin tablets both reduce total cholesterol, low density lipoprotein cholesterol (ldl-c) and increase high density lipoprotein cholesterol (hdl-c).

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Epidemiology of Dyslipidemia in the Asia Pacific Region

Cited by 121 publications

References 18 publications

Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence

Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence

Effect of Soy Milk and Mung Bean Porridge on Serum Triglycerides among Postmen-opausal Women

Role of simvastatin and allium sativum on lipid profile in diabetic dyslipidemic patients: a comparative study.

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