Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence

Wong, Sok Kuan; Kamisah, Yusof; Mohamed, Norazlina; Muhammad, Norliza; Masbah, Norliana; Azlina, Mohd Fahami Nur; Mohamed, Isa Naina; Shuid, Ahmad Nazun; Saad, Qodriyah Mohd; Abdullah, Aceng; Mohamad, Nur-Vaizura; Ibrahim, Nurul ‘Izzah; Pang, Kok-Lun; Chow, Yoke Yue; Thong, Benjamin Ka Seng; Subramaniam, Shaanthana; Chan, Chin Yi; Ima‐Nirwana, Soelaiman; Chin, Ken Min

doi:10.3390/nu12010259

Cited by 54 publications

(32 citation statements)

References 387 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The tocotrienol-rich-fraction (TRF) of palm oil has been anticipated as an e cient alternative for αtocopherol due to its potent antioxidant properties in vitro (41)(42)(43)(44)(45). Although there was no report on TRF effect on HSP70, the present study ndings are in agreement with a number of studies that suggest a higher antioxidant potency of tocotrienols compared to tocopherols in vitro; as HSP70 reduction has been earlier related in this discussion to vitamin E antioxidant function.…”

Section: Comparative Effect Of α-Tocopherol and Palm-tocotrienol Richsupporting

confidence: 90%

Comparative effect of vitamin E compounds on HSP70 expression in response to acute redox imbalance in Chang liver cells

Khorami¹,

Mutalib²,

Khaza’ai³

2020

Preprint

View full text Add to dashboard Cite

Background: HSP70 represents the most highly induced member of the stress protein family which is constitutively expressed in normal cell conditions as chaperon and rapidly upregulated in response to stress conditions. Vitamin E compounds are considered to be the most potent oxidation chain breaking compounds. Although α-tocopherol, has been long considered as the most potent antioxidant among the vitamin E isomers, many studies have recently suggested a higher antioxidant potency of tocotrienols compared to tocopherols. Present study was carried out to investigate the effects of tocotrienol supplementation compared to α-tocopherol on HSP70 expression.Methods: To assess whether the increase in HSP70 secondary to the stress caused by the oxidant could decrease in the presence of vitamin E; two groups of cells were incubated for 4 hours with α-tocopherol and palm tocotrienol-rich fraction respectively with concentration of 10, 20 and 30 μg/ml after the cells were pre-exposed to oxidative stress.Results: The comparison between the negative control which represents the basal expression of HSP70 and the positive control that represents the expression of HSP70 as a response to the oxidant, has clearly indicated that treatment with 100 μM copper sulphates for 24 hours resulted in a significant up-regulation of HSP70 expression. The present study has shown that the overall effect of vitamin E compounds seems to reduce the increase in HSP70 expression. α-tocopherol tended to trigger a more constant rate of response to the dose given but unable to significantly induced the decrease of the HSP70 expression as compared to tocotrienol.Conclusion: Treatment with vitamin E has conferred significant protection against stress induced cellular damage. Whether the reduction of HSP70 by vitamin E is deleterious or beneficial is still controversial and needs to be considered.

show abstract

Section: Comparative Effect Of α-Tocopherol and Palm-tocotrienol Richsupporting

confidence: 90%

Comparative effect of vitamin E compounds on HSP70 expression in response to acute redox imbalance in Chang liver cells

Khorami¹,

Mutalib²,

Khaza’ai³

2020

Preprint

View full text Add to dashboard Cite

show abstract

“…Tocols can limit lipid peroxidation in cell membranes and scavenging reactive oxygen species and protect tissues from consequent oxidative damage. Thus, supra-nutritional doses of tocols have been reported for cardiovascular diseases, cancer, chronic inflammation, Alzheimer's disease, and Parkinson's disease [9]. Tocotrienols are reported to be superior to tocopherols in the prevention and treatment of major chronic diseases, as their unsaturated chain facilitating cell penetration is highly antioxidative [10].…”

Section: Introductionmentioning

confidence: 99%

Assessing the Impact of Oil Types and Grades on Tocopherol and Tocotrienol Contents in Vegetable Oils with Chemometric Methods

Wen

Xue

et al. 2020

Molecules

View full text Add to dashboard Cite

The consumption of vegetable oil is an important way for the body to obtain tocols. However, the impact of oil types and grades on the tocopherol and tocotrienol contents in vegetable oils is unclear. In this study, nine types of traditional edible oils and ten types of self-produced new types of vegetable oil were used to analyze eight kinds of tocols. The results showed that the oil types exerted a great impact on the tocol content of traditional edible oils. Soybean oils, corn oils, and rapeseed oils all could be well distinguished from sunflower oils. Both sunflower oils and cotton seed oils showed major differences from camellia oils as well as sesame oils. Among them, rice bran oils contained the most abundant types of tocols. New types of oil, especially sacha inchi oil, have provided a new approach to obtaining oils with a high tocol content. Oil refinement leads to the loss of tocols in vegetable oil, and the degree of oil refinement determines the oil grade. However, the oil grade could not imply the final tocol content in oil from market. This study could be beneficial for the oil industry and dietary nutrition.

show abstract

“…As a potent antioxidant, tocotrienols exert a variety of beneficial biological and health effects. Tocotrienols have been shown to have cardioprotective and anti-ageing effects [10]. Studies have also suggested that tocotrienols prevent atherosclerosis and improved blood vessel function in diabetics [10].…”

Section: Introductionmentioning

confidence: 99%

Palm Oil Tocotrienols in Cancer Chemoprevention and Treatment

Abdullah¹,

Atia²,

Alrawaiq³

et al. 2022

Elaeis Guineensis

Self Cite

View full text Add to dashboard Cite

Cancer remains a worrying cause of fatality worldwide despite the advancement in medicine. Among the dietary phytonutrients, tocotrienols have been extensively studied for their bioactivity against cancer. Palm oil is a rich source of tocotrienols. The most common formulation of tocotrienols is the tocotrienol-rich fraction of palm oil (TRF). The anticancer activities of tocotrienols were once presumed due to their antioxidant and free radical scavenging properties. However, recent evidence suggested that tocotrienols are capable of demonstrating cancer-fighting properties through their influence in various signalling pathways. The selectivity of tocotrienols in killing cancer cells without affecting normal cells is indicative of their potential role in cancer treatment and prevention. Tocotrienols had proven to be particularly effective in the chemoprevention and treatment of breast, colorectal, pancreatic, prostate and liver cancers in many in vitro and in vivo animal experiments. However, the efficacy of tocotrienols in the management of human cancers are still questionable due to their poor bioavailability and lack of well-designed clinical trials. Nevertheless, due to their superb safety profiles, palm oil tocotrienols are still considered ideal candidates for future large scale clinical trials to prove their efficacy to treat or prevent cancers in humans.

show abstract

Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence

Cited by 54 publications

References 387 publications

Comparative effect of vitamin E compounds on HSP70 expression in response to acute redox imbalance in Chang liver cells

Comparative effect of vitamin E compounds on HSP70 expression in response to acute redox imbalance in Chang liver cells

Assessing the Impact of Oil Types and Grades on Tocopherol and Tocotrienol Contents in Vegetable Oils with Chemometric Methods

Palm Oil Tocotrienols in Cancer Chemoprevention and Treatment

Contact Info

Product

Resources

About