Envenenamentos ofídicos em uma região da Amazônia Ocidental Brasileira

Câmara, Ozianndeny Ferreira; Silva, Delcio Damasceno da; Holanda, Marlon Negreiros de; Bernarde, Paulo Sérgio; Silva, Ageane Mota da; Monteiro, Wuelton Marcelo; Lima, Marcos Venícius Malveira de; Monteiro, Adilson; Wajnsztejn, Rubens

doi:10.7322/jhgd.v30.9958

Cited by 8 publications

(10 citation statements)

References 29 publications

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“…Do total de ocorrências com serpentes peçonhentas (n=2.840), 78% eram do gênero Bothrops, enquanto 2% eram do gênero Lachesis, seguido de Crotalus (1%) e por fim, o gênero Micrurus (n=3). O alto índice de acidentes com gênero Bothrops, está de acordo com o padrão relatado no Brasil nos últimos anos (Silva, et al, 2019;Machado, 2018), e corrobora com pesquisas similares da região amazônica (Silva, et al, 2016;Melo & Maqui, 2020;Câmara, et al, 2020) e demais localidades brasileiras (Barreto, et al, 2010;Cheung & Machado, 2017;Matos & Ignotti, 2018).…”

Section: Resultsunclassified

Aspectos epidemiológicos dos acidentes ofídicos ocorridos na Região de Integração Lago de Tucuruí entre os anos 2010 e 2019

Brandão

Andrade

Santos

2021

RSD

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Introdução: Os acidentes ofídicos representam um sério problema na saúde pública pela grande incidência e gravidade. No Brasil são causados pelas serpentes dos gêneros Crotalus, Lachesis, Bothrops e Micrurus. Objetivos: o presente trabalho objetivou a investigação da prevalência de acidentes ofídicos e variáveis relacionadas na Região de Integração Lago Tucuruí entre os anos 2010 a 2019. Metodologia: Nessa ótica, foi realizado um estudo epidemiológico descritivo, os dados foram obtidos através do Sistema de Informação de Agravos de Notificação (SINAN), tabulados e analisados através dos programas Microsoft Excel, BioStat 5.0 e PAST 3.04. As variáveis utilizadas foram: sexo, faixa etária, escolaridade, município de ocorrência, mês do acidente, gênero da serpente, tempo entre picada-atendimento, gravidade e evolução final. Resultados: No período analisado houve 3.534 ocorrências. As vítimas foram predominantemente do sexo masculino (77%), 20 a 39 anos (38%), com baixa escolaridade (61%); o Município de Novo Repartimento apresentou maior número de casos (30%) e taxa de prevalência por mil habitantes (17,19 casos/1.000 habitantes); observou-se maior frequência de eventos no período de alta pluviosidade (63%); dos acidentes provocados por serpentes peçonhentas (N=2.840), o gênero Bothrops foi o responsáveis pela maioria (78%); com relação ao atendimento houve predominância no decorrer de 6 horas (71%) destas 45% em até 3 horas; a maioria das ocorrências foi classificada como leve (63%), com evolução clínica para a cura (81%). Considerações final: A criação do perfil epidemiológico do ofidismo em nossa região, é crucial para contribuir com estratégias de combate e controle voltadas para as localidades mais afetadas.

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Section: Resultsunclassified

Aspectos epidemiológicos dos acidentes ofídicos ocorridos na Região de Integração Lago de Tucuruí entre os anos 2010 e 2019

Brandão

Andrade

Santos

2021

RSD

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“…Some Brazilian studies in Brazil have also proposed to assess the time from snakebite to patient care [ 14 , 15 ]. However, these are local studies starting from a casualty base, and their various outcomes are observed, considering specific small-scale analysis units.…”

Section: Discussionmentioning

confidence: 99%

“…Few materials have been found in Brazil and international literature. Snakebite accidents and therapeutic care were recently analyzed in municipalities like Vassouras (RJ) [ 14 ] and Cruzeiro do Sul (AC), in the Brazilian Amazon [ 15 ]. Although they did not directly highlight geographic accessibility, they addressed the conditions for obtaining treatment in the respective municipalities.…”

Section: Introductionmentioning

confidence: 99%

Geographical accessibility to the supply of antiophidic sera in Brazil: Timely access possibilities

Oliveira

Silva

2022

PLoS ONE

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Snakebite accidents are considered category A neglected tropical diseases. Brazil stands out for snakebite accidents, mainly in the Amazon region. The best possible care after snakebite accidents is to obtain antiophidic sera on time. And the maximum ideal time to reach it is about 2 hours after an accident. Based on public health information and using a tool to analyze geographical accessibility, we evaluate the possibility of reaching Brazilian serum-providing health facilities from the relationship between population distribution and commuting time. In this exploratory descriptive study, the geographic accessibility of Brazilian population to health facilities that supply antiophidic serum is evaluated through a methodology that articulates several issues that influence the commuting time to health units (ACCESSMOD): population and facilities’ distribution, transportation network and means, relief and land use, which were obtained in Brazilian and international sources. The relative importance of the population without the possibility of reaching a facility in two hours is highlighted for Macro-Regions, States and municipalities. About nine million people live in locations more than two hours away from serum-providing facilities, with relevant variations between regions, states, and municipalities. States like Mato Grosso, Pará and Maranhão had the most important participation of population with reaching time problems to those units. The most significant gaps are found in areas with a dispersed population and sometimes characterized by a high incidence of snakebites, such as in the North of the country, especially in the Northeastern Pará state. Even using a 2010 population distribution information, because of the 2020 Census postponement, the tendencies and characteristics analyzed reveal challenging situations over the country. The growing availability of serum-providing health facilities, the enhanced possibilities of transporting accident victims, and even the availability of sera in other types of establishments are actions that would allow expanding the possibilities of access to serum supply.

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“…The state of Tocantins maintains the national epidemiological standard for snakebite accidents, with accidents predominating for rural workers, with the lower limbs being the most affected (FEITOSA et al, 2015;LEOBAS et al, 2016). These accidents are aggravated by the increase in time between the accident and the start of treatment, which is more frequent in rural accidents, due to the distance and difficulty of commuting to the treatment units (GUTIÉRREZ et al, 2011;FEITOSA et al, 2015;LEOBAS et al, 2016;CÂMARA et al, 2020). In the state of Tocantins, patients treated in the first hour after the accident represented 24% of the notifications (1640 bothropic accidents), a percentage lower than that observed in Brazil (27% of bothropic accidents).…”

Section: Introductionmentioning

confidence: 99%

Neuromuscular block induced by Bothrops moojeni snake venom and the effect of Jatropha elliptica starch

Rodrigues

Yoshida

Franco

et al. 2021

RICA

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This research evaluated the effect of Bothrops moojeni venom on neuromuscular activity and verified the anti-phallic potential of the J. elliptica starch in this model. The venom was obtained from snakes collected in the state of Tocantins, the protein profile evaluated in electrophoresis (SDS-PAGE), and the activity on the phrenic-diaphragm nerve of mice determined in 50 µg/mL of venom. The JeP, obtained by hand, was sieved in a sieve for granulometric analysis and concentrations of 100 and 1000 µg/mL were tested to verify its anti-phallic potential on the action of the poison. The following models were used: pre-venom - addition of venom and after 15 min addition of JeP; post-poison - addition of JeP and after 15 min the addition of poison; and pre-incubation - for 30 min, of poison with JeP or commercial antivenom. The poison had proteins from 10 to 60 kDa, which induced 50% of neuromuscular activity block in 71.5 ± 8.9 min (T50). The pre-venom and post-venom models with JeP 100 µg/mL prolonged phrenic nerve activity time (100.9 ± 7.6 min and 97 ± 6.1 min, respectively). The results obtained for 1000 µg/mL and in the model of pre-incubation of the venom with JeP 100 (78.2 ± 9.2); 1000 µg/mL (86.5 ± 8.9) and with commercial botropic antivenom (80.2 ± 14.1), did not interfere with the activity of the venom on the phrenic nerve. Bothrops moojeni venom induces neuromuscular block and the lower concentration of the starch caused a protective effect on the junction, before and after the administration of the venom.

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Envenenamentos ofídicos em uma região da Amazônia Ocidental Brasileira

Cited by 8 publications

References 29 publications

Aspectos epidemiológicos dos acidentes ofídicos ocorridos na Região de Integração Lago de Tucuruí entre os anos 2010 e 2019

Aspectos epidemiológicos dos acidentes ofídicos ocorridos na Região de Integração Lago de Tucuruí entre os anos 2010 e 2019

Geographical accessibility to the supply of antiophidic sera in Brazil: Timely access possibilities

Neuromuscular block induced by Bothrops moojeni snake venom and the effect of Jatropha elliptica starch

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