Enamel Matrix Derivative in the Treatment of Human Intrabony Osseous Defects

Okuda, K; Momose, Manabu; Miyazaki, Akira; Murata, Masashi; Yokoyama, Shigeru; Yonezawa, Yukari; Wolff, Larry F.; Yoshie, Hiromasa

doi:10.1902/jop.2000.71.12.1821

Cited by 102 publications

(162 citation statements)

References 40 publications

(51 reference statements)

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“…This difference may be explained by several factors. In addition to a difference in patient populations, the mean value for baseline PD in the present study subjects ‫63.1ע82.7(‬ mm) was approximately 1 mm deeper than that ‫19.0ע33.6(‬ mm) reported by Okuda et al 15) . The CAL gain after regenerative periodontal treatment has been shown to be dependent on the initial PD; that is, the deeper the initial PD, the greater the PD reduction and CAL gain 5,16) .…”

Section: Discussioncontrasting

confidence: 77%

“…2). These values are slightly less than the ‫22.1מ‬ mm recession reported by Okuda et al 15) . A study by Sculean et al 20) demonstrated less recession at sites treated with EMD compared to guided tissue regeneration (GTR) treated sites.…”

Section: Discussioncontrasting

confidence: 53%

“…Mean CAL gain at 1-year was ‫64.1ע93.3‬ mm. This result demonstrated greater improvement than was shown by Okuda et al 15) , who reported a mean CAL gain of ‫70.1ע27.1‬ mm in 1 year after the EMD treatment in Japanese patients. This difference may be explained by several factors.…”

Section: Discussionsupporting

confidence: 47%

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Treatment of Intrabony Periodontal Defects with Enamel Matrix Derivative in Private Practice: A Long-term Retrospective Study

Saitô

Nanbu²,

Nagahata³

et al. 2008

Bull. Tokyo Dent. Coll.

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The present study describes treatment of intrabony periodontal defects with enamel matrix derivative (EMD) in private practice. Ten patients with clinical diagnosis of chronic periodontitis were subjected to data analysis. A total of 18 teeth with various osseous defects received regenerative therapy with EMD, and were followed for a minimum of 2 years. Treatment of the intrabony defects with EMD led to a statistically significant improvement in the mean value of probing depth at 1-year when compared with at the baseline (pϽ0.01). Reduction in probing depth was achieved with minimal recession of the gingival margin, and was maintained over the 2-year observation period with no significant change. Mean values of attachment gain at 1 and 2 years were of clinical significance: ‫64.1ע93.3‬ mm and ‫04.1ע22.3‬ mm, respectively. Although one tooth was extracted because of subsequent loss of attachment and bone, most teeth treated have been successfully maintained for 2 to 7 years with no significant signs of disease progression. In conclusion, EMD treatment of intrabony osseous defects yielded clinically favorable responses. The gain in clinical attachment can be longitudinally maintained in a private practice setting. Further controlled studies are needed to elucidate the clinical significance of EMD treatment.

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Section: Discussioncontrasting

confidence: 77%

Section: Discussioncontrasting

confidence: 53%

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Treatment of Intrabony Periodontal Defects with Enamel Matrix Derivative in Private Practice: A Long-term Retrospective Study

Saitô

Nanbu²,

Nagahata³

et al. 2008

Bull. Tokyo Dent. Coll.

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“…Previous clinical trials have shown mean PPD reductions ranging from 3.3 to 4.3 mm for the EMP group and from 2.2 to 3.7 mm for the control group at an interval of 8 to 12 months after treatment. 3,7,10,13,19 In the present study, no significant differences in PPD reduction were observed between the EMP (3.7 mm) and OFD (4.0 mm) groups after 6 months. However, our results disagree with those of previ- ous studies that reported a significantly greater PPD reduction for the EMP group.…”

Section: Discussioncontrasting

confidence: 58%

“…5,15 These positive results in animals 17 were later confirmed by histological findings in humans 15 and by clinical improvement observed in controlled clinical trials. 3,7,8,10,13,19 Thus, the purpose of this study was to compare the results of periodontal clinical parameters after treatment of intrabony defects with open flap debridement (OFP) combined or not with enamel matrix protein (EMP).…”

Section: Introductionmentioning

confidence: 99%

Effect of enamel matrix proteins on the treatment of intrabony defects: a split-mouth randomized controlled trial study

et al. 2007

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241Effect of enamel matrix proteins on the treatment of intrabony defects . A splitmouth randomized controlled trial study O efeito da proteína da matriz do esmalte no tratamento de defeitos infra-ósseos. Um estudo clínico controlado randomizado boca-dividida Abstract: The objective of this split-mouth, double-blind, randomized controlled trial was to compare the clinical effect of treatment of 2-or 3-wall intrabony defects with open flap debridement (OFD) combined or not with enamel matrix proteins (EMP). Thirteen volunteers were selected with one pair of or more intrabony defects and probing pocket depth (PPD) ≥ 5 mm. All individuals received instructions regarding oral hygiene and were submitted to scaling and root planing. Each participant received the two treatment modalities: test sites were treated with OFD and EMP, and control sites received only OFD. After 6 months, a significant reduction was observed in PPD for the EMP group (from 6.42 ± 1.08 mm to 2.67 ± 1.15 mm) and for the OFD group (from 6.08 ± 1.00 mm to 2.00 ± 0.95 mm) (p < 0.0001), but with no significant difference between groups (p = 0.13). A significant gain in relative attachment level (RAL) was observed in both groups (EMP: from 13.42 ± 1.88 mm to 10.75 ± 2.26 mm, p < 0.001; OFD: from 12.42 ± 1.98 mm to 10.58 ± 2.23 mm, p = 0.013), but with no significant difference between groups (p = 0.85). Gingival recession (GR) was higher in the EMP group (from 1.08 ± 1.50 mm to 2.33 ± 1.43 mm; p = 0.0009) than in the OFD group (from 0.66 ± 1.15 mm to 1.16 ± 1.33 mm; p = 0.16), but this difference was not significant (p = 0.06). In conclusion, the results showed that OFD combined with EMP was not able to improve treatment of intrabony defects compared to OFD alone. Descriptors: Periodontics; Alveolar bone loss; Bone regeneration.Resumo: O objetivo deste estudo clínico controlado, randomizado, duplo-cego, tipo bocadividida foi comparar o efeito clínico do tratamento de defeitos infra-ósseos de 2 ou 3 paredes com retalho de espessura total (RET) associado ou não com a proteína da matriz do esmalte (PME). Treze voluntários com 1 par ou mais de defeitos infra-ósseos foram selecionados com profundidade clínica de sondagem (PCS) ≥ 5 mm. Todos receberam instruções de higiene bucal, raspagem e alisamento radicular. Cada participante recebeu os dois tipos de tratamento: o lado teste foi tratado com RET e PME, e o lado controle recebeu somente RET. Após 6 meses, foi observada uma redução significante na PCS para o grupo PME (de 6,42 ± 1,08 mm para 2,67 ± 1,15 mm) e para o grupo RET (de 6,08 ± 1,00 mm para 2,00 ± 0,95 mm) (p < 0,0001), mas não houve diferença significante entre os grupos (p = 0,13). Um ganho significante de nível clínico de inserção relativo (NCIR) foi observado em ambos os grupos (PME: de 13,42 ± 1,88 mm para 10,75 ± 2,26 mm, p < 0,001; RET: de 12,42 ± 1,98 mm para 10,58 ± 2,23 mm, p = 0,013), mas não houve diferença significante entre os grupos (p = 0,85). A retração gengival (RG) foi maior para o grupo PME (de 1,08 ± 1,50 mm para 2,33 ± 1,43 ...

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Enamel matrix derivative (Emdogain��) for periodontal tissue regeneration in intrabony defects

Esposito¹,

Coulthard²,

Worthington³

2003

Cochrane Database of Systematic Reviews

180

229

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Enamel Matrix Derivative in the Treatment of Human Intrabony Osseous Defects

Abstract: Treatment with flap surgery and EMD, compared to flap surgery with placebo, produced a significantly more favorable clinical improvement in intrabony periodontal defects.

Cited by 102 publications

References 40 publications

Treatment of Intrabony Periodontal Defects with Enamel Matrix Derivative in Private Practice: A Long-term Retrospective Study

Treatment of Intrabony Periodontal Defects with Enamel Matrix Derivative in Private Practice: A Long-term Retrospective Study

Effect of enamel matrix proteins on the treatment of intrabony defects: a split-mouth randomized controlled trial study

Enamel matrix derivative (Emdogain��) for periodontal tissue regeneration in intrabony defects

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