Treatment of Intrabony Periodontal Defects with Enamel Matrix Derivative in Private Practice: A Long-term Retrospective Study

Abstract

The present study describes treatment of intrabony periodontal defects with enamel matrix derivative (EMD) in private practice. Ten patients with clinical diagnosis of chronic periodontitis were subjected to data analysis. A total of 18 teeth with various osseous defects received regenerative therapy with EMD, and were followed for a minimum of 2 years. Treatment of the intrabony defects with EMD led to a statistically significant improvement in the mean value of probing depth at 1-year when compared with at the baseline (pϽ0.01). Reduction in probing depth was achieved with minimal recession of the gingival margin, and was maintained over the 2-year observation period with no significant change. Mean values of attachment gain at 1 and 2 years were of clinical significance: ‫64.1ע93.3‬ mm and ‫04.1ע22.3‬ mm, respectively. Although one tooth was extracted because of subsequent loss of attachment and bone, most teeth treated have been successfully maintained for 2 to 7 years with no significant signs of disease progression. In conclusion, EMD treatment of intrabony osseous defects yielded clinically favorable responses. The gain in clinical attachment can be longitudinally maintained in a private practice setting. Further controlled studies are needed to elucidate the clinical significance of EMD treatment.

Two-year Follow-up of Treatment of Intrabony Periodontal Defect with Enamel Matrix Derivative

“…This gain was comparable with that observed in our earlier study in a private practice setting 15) . A meta analysis of clinical studies on the management of angular osseous defects with EMD 7) revealed a reduction in PD of 4.0 mm (50% of the baseline PD) and gain in CAL of 3.2 mm (33% of the original attachment level) in a total of 317 lesions over an observation period ranging from 6 to 12 months.…”

“…Interventions ranged from localized to quadrant surgery, with at least one tooth in the quadrant having intrabony defects matching the above-mentioned criteria. Regenerative therapy with EMD was performed at 25 sites (17 molars, 3 premolars, 3 canines, and 2 incisors) in 13 patients by the standard procedure as described previously 15) . Briefly, a full-thickness periodontal flap (papilla preservation technique) was employed to gain access to the root surface for scaling and root planing.…”

Treatment of Periodontal Defects with Enamel Matrix Derivative: Clinical Evaluation at Early Healing Stages

“…In their international multi-center study, Tonetti et al 21) reported a mean CAL gain of 3.1 mm at 1 year. Previous study by our group evaluated the long-term clinical outcomes of treatment with EMD in a private practice setting 17) . The mean CAL gain at 6 months was 3.6 mm, which was significantly greater than that (2.2 mm) observed in our study on guided tissue regeneration utilizing bioresorbable membrane 26) .…”

“…Interventions ranged from localized to quadrant surgery, with at least one tooth in the quadrant having intrabony defects matching the abovementioned criteria. Regenerative therapy with EMD was performed by the standard procedure as described previously 17) . Briefly, a fullthickness periodontal flap (papilla preservation technique) was employed to gain access to the root surface for scaling and root planing.…”

In vitroEffect of Mouthrinse Containing Essential Oils on Proliferation and Migration of Gingival Epithelial Cells

“…Our results that the EO + E had no inhibitory effects on the early behaviors of gingival epithelial cells may in part support such findings. In our previous clinical study, the EO + E mouthrinse was introduced as a patient home care regimen following periodontal regenerative therapy (Saito et al, 2008). The postoperative healing was uneventful, and no adverse effects related to the use of the EO + E were reported.…”