Treatment of Periodontal Defects with Enamel Matrix Derivative: Clinical Evaluation at Early Healing Stages

Saitô, Atsushi; Hayakawa, Hisao; Ota, Kei; Fujinami, Koushu; Nikaido, Masahiko; Makiishi, Takemi

doi:10.2209/tdcpublication.51.85

Cited by 13 publications

(13 citation statements)

References 26 publications

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“…There was a progressive improvement in bone fill from at 1 year to 36% at 2 years. It has been reported that distinct radiographical bone fill was observed at as early as 5–6 months after the EMD therapy [20, 21]. Heijl et al [20] also reported that further bone gain may be expected for as long as 3 years, which collaborates our findings.…”

Section: Discussionsupporting

confidence: 90%

Periodontal regenerative therapy with enamel matrix derivative in the treatment of intrabony defects: a prospective 2-year study

et al. 2017

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ObjectiveTo date, enamel matrix derivative (EMD) has been considered to be one of the few biomaterials for clinical use capable of demonstrating true periodontal regeneration. The aim of this two-center prospective clinical study was to evaluate 2-year outcome of periodontal regenerative therapy using EMD in the treatment of intrabony defects, performed as an ‘advanced medical treatment’ under the national healthcare system in Japan.ResultsPatients with chronic periodontitis who have completed initial periodontal therapy at either of the two dental school clinics were enrolled. Each contributed at least one intrabony defect of ≥3 mm in depth. During surgery, EMD was applied to the defect following debridement. Twenty-two participants (mean age 55.2 years old, 9 men and 13 women) completed 2-year reevaluation, and a total of 42 defects were subjected to data analysis. Mean gains in clinical attachment level (CAL) at 1 and 2 years were 2.9 mm (38% of baseline CAL) and 3.1 mm (41%), respectively, both showing a significant improvement from baseline. There was also a significant reduction in probing depth (PD): mean reductions at 1 and 2 years were 3.2 and 3.3 mm, respectively. There was a progressive improvement in the mean percentages of bone fill from 26% at 1 year to 36% at 2 years. No significant difference in CAL gain at 2 years was found between 3-wall bone defects and other defect types combined. In multiple regression analysis, the baseline PD was significantly associated with CAL gain at 2 years. In this population of patients, the treatment of intrabony defects with EMD yielded clinically favorable outcomes, as assessed by periodontal and radiographical parameters, over a period of 2 years.Electronic supplementary materialThe online version of this article (doi:10.1186/s13104-017-2572-2) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 90%

Periodontal regenerative therapy with enamel matrix derivative in the treatment of intrabony defects: a prospective 2-year study

et al. 2017

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“…Although clinical results are often dependent upon the dimension and morphology of the defect 6) , mean CAL gain (2.8 mm) observed for sites with regenerative therapy appeared to be comparable to that reported in our previous study 18) and others 13,20) . An increase in the proportion of defects demonstrating a CAL gain≥4 mm was also observed for regenerative therapy when compared to open flap debridement.…”

Section: Discussionsupporting

confidence: 82%

Clinical Outcome of Surgical Periodontal Therapy: A Short-term Retrospective Study

Hayakawa

Fujinami

Ida

et al. 2012

Bull. Tokyo Dent. Coll.

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This study aimed to investigate retrospectively the outcome of surgical periodontal therapy. Periodontal surgeries implemented at General Dentistry, Tokyo Dental College Suidobashi Hospital during the period of April 2010 through March 2012 were subjected to data analysis. After initial periodontal therapy, 17 clinicians performed a total of 138 periodontal surgeries in 80 patients with moderate to advanced periodontitis (31 men and 49 women; mean age 54). Cases (sites) operated were as follows: open flap debridement=102, periodontal regenerative therapy=29 (17 for intrabony defects, 12 for furcation involvements) and periodontal plastic surgery=7. Enamel matrix derivative or bone graft was used for regenerative therapy. Clinical data were analyzed focusing on the comparison between open flap debridement and regenerative therapy. At 5 months after open flap debridement, mean reduction in probing depth (PD) and gain in clinical attachment level (CAL) was 3.9 mm (range 11.0-9.0) and 2.3 mm (range 11.0-9.0), respectively. The corresponding values with regenerative therapy were 4.0 mm (range 0-8.0) and 2.8 mm (11.0-6.0), respectively. At sites with initial PD≥8 mm, a significantly greater gain in CAL was obtained with the regenerative therapy than with flap surgery (mean CAL gain 4.3 mm vs. 2.9 mm, p<0.05). Periodontal surgery performed in our clinical setting demonstrated a favorable short-term outcome. Our data suggest the efficacy of regenerative therapy, in particular for the treatment of deep pockets.

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“…Observations on early post-operative healing have been described in detail elsewhere 14) . A statistically significant improvement in mean PD was already observed at 6 months postsurgically (Fig.…”

Section: Resultsmentioning

confidence: 99%

“…In an earlier study, we evaluated treatment of intrabony periodontal defects with EMD during the early stages of healing 14) and found that it was capable of inducing favorable periodontal healing with a high level of predictability. Based on this finding, we have extended our observations.…”

Section: Introductionmentioning

confidence: 99%

Two-year Follow-up of Treatment of Intrabony Periodontal Defect with Enamel Matrix Derivative

Fujinami

Hayakawa

Ota

et al. 2011

Bull. Tokyo Dent. Coll.

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The aim of this retrospective clinical study was to evaluate 2-year follow-up results following regenerative periodontal surgery for intrabony defects using enamel matrix derivative (EMD). Thirteen patients (mean age: 53 years) with a clinical diagnosis of chronic periodontitis were subjected to data analysis. A total of 25 sites with intrabony defects received regenerative therapy with EMD. Follow-up continued for a minimum of 2 years. Treatment of intrabony defects with EMD yielded a statistically significant improvement in the mean values of probing depth and gains in clinical attachment level (CAL) at 2 years compared with those at baseline (pϽ0.001). Sites treated with EMD demonstrated a mean CAL gain of 3.4 mm and 3.2 mm at 6 months and 2 years, respectively. No statistically significant difference in gain in CAL was found between the 6-month and 2-year results. A gain in CAL of Ն3 mm from at baseline was found in 17 sites at 2 years. This gain was achieved with minimal recession of gingival margin and was sustained over a given period of time. A trend toward a progressive increase in radiopacity, suggestive of bone-fill, was observed. In summary, treatment of intrabony defects with EMD resulted in clinically favorable outcomes. The clinical improvements obtained with regenerative therapy with EMD were maintained over a period of 2 years.

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Treatment of Periodontal Defects with Enamel Matrix Derivative: Clinical Evaluation at Early Healing Stages

Cited by 13 publications

References 26 publications

Periodontal regenerative therapy with enamel matrix derivative in the treatment of intrabony defects: a prospective 2-year study

Periodontal regenerative therapy with enamel matrix derivative in the treatment of intrabony defects: a prospective 2-year study

Clinical Outcome of Surgical Periodontal Therapy: A Short-term Retrospective Study

Two-year Follow-up of Treatment of Intrabony Periodontal Defect with Enamel Matrix Derivative

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