No abstract

Treatment with flap surgery and EMD, compared to flap surgery with placebo, produced a significantly more favorable clinical improvement in intrabony periodontal defects.

No abstract

Polymorphonuclear neutrophil (PMN) phagocytic function has been shown to be impaired in some patients with periodontitis. PMN constitutively express members of two immunoglobulin G receptor (Fc␥R) classes: Fc␥RIIa (CD32) and Fc␥RIIIb (CD16). Both receptors exhibit genetically determined structural and functional biallelic polymorphisms, which have been shown to influence PMN phagocytic function. In this study, we assessed the relevance of these Fc␥R polymorphisms to susceptibility to adult periodontitis and recurrence rate. The distribution of Fc␥RIIa and Fc␥RIIIb genotypes of 100 Japanese patients with adult periodontitis during follow-up was compared to the distribution of genotypes in 105 race-matched healthy controls. No significant skewing of distributions of Fc␥RIIa and Fc␥RIIIb genotypes was observed between patients and controls. Notably, however, a significant overrepresentation of the Fc␥RIIIb-NA2 allotype was found in patients with disease recurrence (P < 0.05; odds ratio, 4.29; 95% confidence interval, 1.19 to 16.24). Moreover, the annual rate of recurrence was significantly higher in patients with the Fc␥RIIIb-NA2/NA2 and Fc␥RIIIb-NA1/NA2 genotypes than in Fc␥RIIIb-NA1/NA1 individuals (P < 0.05). Fc␥RIIa-R/R131 individuals also exhibited higher recurrence rates, though the difference was not statistically significant (P ‫؍‬ 0.06). These results suggest that the Fc␥RIIIb-NA2 allotype represents a risk factor for recurrence of adult periodontitis.

Our data suggest that Nd:YAG laser and ultrasonic scaling treatments showed significant improvements regarding the clinical parameters and subgingival microflora compared to the baseline, but no significant difference was observed between the 3 groups.