Effects of maternal dietary olive oil on pathways involved in diabetic embryopathy

Higa, Romina; Roberti, Sabrina Lorena; Musikant, Daniel; Mazzucco, María Belén; White, Verónica; Jawerbaum, Alicia

doi:10.1016/j.reprotox.2014.09.004

Cited by 13 publications

(9 citation statements)

References 55 publications

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“…Our previous studies performed in experimental models of diabetes and pregnancy have shown that a maternal EVOO dietary treatment regulates PPAR pathways and reduces proinflammatory markers in rat embryos, foetuses, placentas and in the offspring's heart 6,11‐13,15 . The dose of olive oil that shows these beneficial effects in animal models of diabetes and pregnancy provides half of the lipid‐derived calories (5% in an 11% lipid content diet).…”

Section: Discussionmentioning

confidence: 99%

“…PPARs are nutrigenomic agents, being monounsaturated fatty acids (MUFAs, the main components of olive oil), PPARs endogenous ligands 9,10 . In experimental models of diabetes and pregnancy, our previous studies have shown that diets enriched in extra virgin olive oil (EVOO) lead to antiinflammatory effects, as shown by the ability of these diets to prevent increased levels of proinflammatory cytokines, nitric oxide overproduction, and matrix metalloproteinases (MMPs) overexpression in placentas, embryos and different foetal organs 11‐16 . Studies have also shown that although maternal EVOO‐dietary treatments do not prevent programming of metabolic diseases in the offspring of diabetic animals, this treatment reduces the levels of proinflammatory markers in the offspring's heart and prevents hypertriglyceridemia in the adult offspring of diabetic rats 11,16 …”

Section: Introductionmentioning

confidence: 99%

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An extra virgin olive oil‐enriched diet improves maternal, placental, and cord blood parameters in GDM pregnancies

Ribot

Diaz

Fazio

et al. 2020

Diabetes Metabolism Res

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Aims To address the effect of a diet enriched in extra virgin olive oil (EVOO) on maternal metabolic parameters and placental proinflammatory markers in Gestational diabetes mellitus (GDM) patients. Methods Pregnant women at 24‐28 weeks of gestation were enrolled: 33 GDM patients which were randomly assigned or not to the EVOO‐enriched group and 17 healthy controls. Metabolic parameters were determined. Peroxisome proliferator activated receptor (PPAR) γ and PPARα protein expression, expression of microRNA (miR)‐130a and miR‐518d (which respectively target these PPAR isoforms) and levels of proinflammatory markers were evaluated in term placentas. Matrix metalloproteinases (MMPs) activity was evaluated in term placentas and umbilical cord blood. Results GDM patients that received the EVOO‐enriched diet showed reduced pregnancy weight gain (GDM‐EVOO:10.3 ± 0.9, GDM:14.2 ± 1.4, P = .03) and reduced triglyceridemia (GDM‐EVOO:231 ± 14, GDM:292 ± 21, P = .02) compared to the non‐EVOO‐enriched GDM group. In GDM placentas, the EVOO‐enriched diet did not regulate PPARγ protein expression or miR‐130a expression, but prevented the reduced PPARα protein expression (P = .02 vs GDM) and the increased miR‐518d expression (P = .009 vs GDM). Increased proinflammatory markers (interleukin‐1β, tumour necrosis factor‐α and nitric oxide overproduction) in GDM placentas were prevented by the EVOO‐enriched diet (respectively P = .001, P = .001 and P = .01 vs GDM). MMPs overactivity was prevented in placenta and umbilical cord blood in the EVOO‐enriched GDM group (MMP‐9: respectively P = .01 and P = .001 vs GDM). Conclusions A diet enriched in EVOO in GDM patients reduced maternal triglyceridemia and weight gain and has antiinflammatory properties in placenta and umbilical cord blood, possibly mediated by the regulation of PPAR pathways.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

An extra virgin olive oil‐enriched diet improves maternal, placental, and cord blood parameters in GDM pregnancies

Ribot

Diaz

Fazio

et al. 2020

Diabetes Metabolism Res

Self Cite

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“…The mRNA levels of Cox, Nrf1, Tfam, Pparδ and Pgc-1α were evaluated by semi-quantitative reverse transcription polymerase chain reaction (RT-PCR), as previously described (Higa et al, 2014). Four pooled embryos from each rat in each experimental group (n = 9) were kept in RNAlater® (Ambion, Texas, USA) at −20°C and RNA was extracted with RNAzol (Molecular Research Center, Cincinnati, USA) in accordance with the manufacturer's instructions.…”

Section: Analysis Of Mrna Levels Of Cox Nrf1 Tfam Pparδ and Pgc-1αmentioning

confidence: 99%

“…The nuclear receptor PPARδ participates in cell proliferation and differentiation in adult tissue as well as in fetal tissues and has antiinflammatory properties (Coll et al, 2010;Rotman et al, 2006). We have previously found that aberrant PPARδ signalling is involved in embryo dysmorphogenesis and that PPARδ is reduced in embryos from severe diabetic rats (Higa et al, 2007(Higa et al, , 2014. In the present study, we also found reduced Pparδ mRNA levels in the embryos from mild diabetic rats and that idebenone was able to modulate Pparδ transcription, increasing the reduced mRNA levels of this nuclear receptor.…”

Section: Article In Pressmentioning

confidence: 99%

Effect of the antioxidant idebenone on maternal diabetes-induced embryo alterations during early organogenesis

Higa

Roberti

Mazzucco

et al. 2018

Reproductive BioMedicine Online

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“…Some placental defects in PPARγ and PPARδ null mice results in the death of 27 embryos indicating these forms are essential, and their absence via other PPAR isoforms rescue adverse phenotype (Wang et al, 2007;Barak et al, 2008). Previous literature reveals that decreased embryonic PPARδ and decidual PPARγ in diabetic rats during early organ development related to compromised embryo morphogenesis (Higa et al, 2010;Higa et al, 2014). Moreover, alterations in the fatty acid metabolism consist of massive crosstalk between PPAR and mTOR in different cell types have been documented (Blanchard et al, 2012;Angela et al, 2016) and all these nutrient pathways share target with fatty acid-binding protein-4 (FABP4) (Wang et al, 2017).…”

Section: Peroxisome Proliferator-activated Receptors (Ppars)mentioning

confidence: 99%

Role of Dietary Amino Acids and Nutrient Sensing System in Pregnancy Associated Disorders

et al. 2020

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Defective implantation is related to pregnancy-associated disorders such as spontaneous miscarriage, intrauterine fetal growth restriction and others. Several factors proclaimed to be involved such as physiological, nutritional, environmental and managemental that leads to cause oxidative stress. Overloading of free radicals promotes oxidative stress, and the internal body system could not combat its ability to encounter the damaging effects and subsequently leading to pregnancy-related disorders. During pregnancy, essential amino acids display important role for optimum fetal growth and other necessary functions for continuing fruitful pregnancy. In this context, dietary amino acids have received much attention regarding the nutritional concerns during pregnancy. Arginine, glutamine, tryptophan and taurine play a crucial role in fetal growth, development and survival while ornithine and proline are important players for the regulation of gene expression, protein synthesis and angiogenesis. Moreover, amino acids also stimulate the mammalian target of rapamycin (mTOR) signaling pathway which plays a central role in the synthesis of proteins in placenta, uterus and fetus. This review article explores the significances of dietary amino acids in pregnancy development, regulation of nutrient-sensing pathways such as mTOR, peroxisome proliferator-activated receptors (PPARs), insulin/insulin-like growth factor signaling pathway (IIS) and 5′ adenosine monophosphate-activated protein kinase (AMPK) which exhibit important role in reproduction and its related problems. In addition, the antioxidant function of dietary amino acids against oxidative stress triggering pregnancy disorders and their possible outcomes will also be enlightened. Dietary supplementation of amino acids during pregnancy could help mitigate reproductive disorders and thereby improving fertility in animals as well as humans.

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Effects of maternal dietary olive oil on pathways involved in diabetic embryopathy

Cited by 13 publications

References 55 publications

An extra virgin olive oil‐enriched diet improves maternal, placental, and cord blood parameters in GDM pregnancies

An extra virgin olive oil‐enriched diet improves maternal, placental, and cord blood parameters in GDM pregnancies

Effect of the antioxidant idebenone on maternal diabetes-induced embryo alterations during early organogenesis

Role of Dietary Amino Acids and Nutrient Sensing System in Pregnancy Associated Disorders

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